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Wang Y, Shen Y, Sun X, et al. Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer. Transl Lung Cancer Res. 2019;8(5):674-681doi: 10.21037/tlcr.2019.10.04.
Wang, Y., Shen, Y., Sun, X., Hong, T. L., Huang, L. S., & Zhong, M. (2019). Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer. Translational lung cancer research, 8(5), 674-681. https://doi.org/10.21037/tlcr.2019.10.04
Wang, Yingqin, et al. "Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer." Translational lung cancer research vol. 8,5 (2019): 674-681. doi: https://doi.org/10.21037/tlcr.2019.10.04
Wang Y, Shen Y, Sun X, Hong TL, Huang LS, Zhong M. Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer. Transl Lung Cancer Res. 2019 Oct;8(5):674-681. doi: 10.21037/tlcr.2019.10.04. PMID: 31737503; PMCID: PMC6835097.
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Transl Lung Cancer Res. 2019 Oct;8(5):674-681. doi: 10.21037/tlcr.2019.10.04.

Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer.

Translational lung cancer research

Yingqin Wang, Yaxing Shen, Xia Sun, Tinah L Hong, Long Shuang Huang, Ming Zhong

Affiliations

  1. Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  2. Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  3. Department of Nephrology, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou 221000, China.
  4. Cancer Institute, Xuzhou Medical University, Xuzhou 221002, China.
  5. New Trier High School, Winnetka, IL, USA.
  6. Department of Pharmacology, Shanghai Hospital of Traditional Chinese Medicine, Shanghai 200032, China.

PMID: 31737503 PMCID: PMC6835097 DOI: 10.21037/tlcr.2019.10.04

Abstract

BACKGROUND: Sphingosine-1-phosphate (S1P), a bioactive lipid, is generally increased in human non-small cell lung cancer (NSCLC). Evidence has shown that the levels of enzymes in S1P metabolism were associated with clinical outcomes in patients with NSCLC. Nevertheless, the roles of mRNA expression of major enzymes (

METHODS: "The Kaplan-Meier plotter" (the KM plotter) is an online database which contains gene expression and clinical data of 1,928 NSCLC patients. In this study, we analyzed the relationship between mRNA expression of major enzymes in S1P metabolism and overall survival (OS) in 1,926 NSCLC patients with the KM plotter. Further analyses stratified by smoking history, non-metastasis patents, clinical stages, negative surgical margin, chemotherapy and radiotherapy were also performed.

RESULTS: High

CONCLUSIONS: The mRNA expression of

2019 Translational Lung Cancer Research. All rights reserved.

Keywords: RNA, messenger; Sphingosine-1-phosphate (S1P); carcinoma; non-small cell lung cancer (NSCLC)

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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