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Polymers (Basel). 2019 Nov 01;11(11). doi: 10.3390/polym11111789.

Combinations of Antimicrobial Polymers with Nanomaterials and Bioactives to Improve Biocidal Therapies.

Polymers

Roberto Yañez-Macías, Alexandra Muñoz-Bonilla, Marco A De Jesús-Tellez, Hortensia Maldonado-Textle, Carlos Guerrero-Sánchez, Ulrich S Schubert, Ramiro Guerrero-Santos

Affiliations

  1. Centro de Investigación en Química Aplicada (CIQA), Boulevard Enrique Reyna No. 140, 25294 Saltillo, Mexico. [email protected].
  2. Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. [email protected].
  3. Centro de Investigación y de Estudios Avanzados (CINVESTAV) Unidad Mérida, A.P. 73, Cordemex, 97310 Mérida, México. [email protected].
  4. Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, D-07743 Jena, Germany. [email protected].
  5. Centro de Investigación en Química Aplicada (CIQA), Boulevard Enrique Reyna No. 140, 25294 Saltillo, Mexico. [email protected].
  6. Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, D-07743 Jena, Germany. [email protected].
  7. Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, D-07743 Jena, Germany. [email protected].
  8. Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, D-07743 Jena, Germany. [email protected].
  9. Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, D-07743 Jena, Germany. [email protected].
  10. Centro de Investigación en Química Aplicada (CIQA), Boulevard Enrique Reyna No. 140, 25294 Saltillo, Mexico. [email protected].

PMID: 31683853 PMCID: PMC6918310 DOI: 10.3390/polym11111789

Abstract

The rise of antibiotic-resistant microorganisms has become a critical issue in recent years and has promoted substantial research efforts directed to the development of more effective antimicrobial therapies utilizing different bactericidal mechanisms to neutralize infectious diseases. Modern approaches employ at least two mixed bioactive agents to enhance bactericidal effects. However, the combinations of drugs may not always show a synergistic effect, and further, could also produce adverse effects or stimulate negative outcomes. Therefore, investigations providing insights into the effective utilization of combinations of biocidal agents are of great interest. Sometimes, combination therapy is needed to avoid resistance development in difficult-to-treat infections or biofilm-associated infections treated with common biocides. Thus, this contribution reviews the literature reports discussing the usage of antimicrobial polymers along with nanomaterials or other inhibitors for the development of more potent biocidal therapies.

Keywords: antibacterials; biocide polymers; cationic copolymers

References

  1. Int J Food Microbiol. 2010 Nov 15;144(1):51-63 - PubMed
  2. Mol Pharm. 2010 Dec 6;7(6):2289-96 - PubMed
  3. Water Res. 2008 Jun;42(12):3066-74 - PubMed
  4. Antimicrob Agents Chemother. 2008 May;52(5):1635-41 - PubMed
  5. Biomacromolecules. 2003 Nov-Dec;4(6):1457-65 - PubMed
  6. Biomacromolecules. 2007 May;8(5):1359-84 - PubMed
  7. ACS Nano. 2011 Sep 27;5(9):6971-80 - PubMed
  8. J Am Chem Soc. 2006 Aug 2;128(30):9798-808 - PubMed
  9. Lancet Oncol. 2002 Aug;3(8):487-97 - PubMed
  10. ACS Nano. 2010 Oct 26;4(10):5731-6 - PubMed
  11. J Am Chem Soc. 2014 Apr 2;136(13):4873-6 - PubMed
  12. Bioresour Technol. 2010 Jul;101(14):5693-700 - PubMed
  13. Int J Antimicrob Agents. 2000 Sep;16(1):5-15 - PubMed
  14. Int J Antimicrob Agents. 2008 Apr;31(4):329-36 - PubMed
  15. Environ Sci Technol. 2008 Oct 1;42(19):7528-34 - PubMed
  16. Langmuir. 2008 Jun 1;24(13):6409-13 - PubMed
  17. ACS Nano. 2014 Oct 28;8(10):10682-6 - PubMed
  18. ACS Infect Dis. 2017 Nov 10;3(11):845-853 - PubMed
  19. ACS Appl Mater Interfaces. 2011 Aug;3(8):3189-94 - PubMed
  20. Biomaterials. 2014 Feb;35(5):1716-24 - PubMed
  21. Nanomedicine. 2010 Oct;6(5):681-8 - PubMed
  22. ACS Appl Mater Interfaces. 2015 Jan 21;7(2):1087-99 - PubMed
  23. Adv Pharm Bull. 2015 Mar;5(1):19-23 - PubMed
  24. Acta Biomater. 2017 Aug;58:421-431 - PubMed
  25. Nanotechnology. 2005 Oct;16(10):2346-53 - PubMed
  26. Acta Biomater. 2014 Oct;10(10):4136-42 - PubMed
  27. Int J Antimicrob Agents. 2010 Nov;36 Suppl 3:S3-7 - PubMed
  28. Lett Appl Microbiol. 1997 Oct;25(4):279-83 - PubMed
  29. ACS Appl Mater Interfaces. 2012 Mar;4(3):1313-23 - PubMed
  30. Acta Biomater. 2016 Jan;29:198-205 - PubMed
  31. Nanomicro Lett. 2015;7(3):219-242 - PubMed
  32. Nat Commun. 2015 Jul 14;6:7722 - PubMed
  33. Carbohydr Polym. 2019 Mar 15;208:477-485 - PubMed
  34. Acc Chem Res. 2008 Dec;41(12):1721-30 - PubMed
  35. J Nanobiotechnology. 2011 Aug 03;9:30 - PubMed
  36. Water Res. 2008 Nov;42(18):4591-602 - PubMed
  37. ACS Nano. 2013 Apr 23;7(4):2891-7 - PubMed
  38. Ups J Med Sci. 2014 May;119(2):149-53 - PubMed
  39. Materials (Basel). 2013 Jun 05;6(6):2295-2350 - PubMed
  40. Nat Rev Microbiol. 2019 Mar;17(3):141-155 - PubMed
  41. Biomacromolecules. 2013 Mar 11;14(3):585-601 - PubMed
  42. Carbohydr Polym. 2012 Jun 5;89(1):111-6 - PubMed
  43. Chem Sci. 2016 Feb 1;7(2):1016-1027 - PubMed
  44. Carbohydr Res. 2010 May 27;345(8):994-8 - PubMed
  45. J Agric Food Chem. 2006 Aug 9;54(16):5814-22 - PubMed
  46. Ann Biomed Eng. 2013 Mar;41(3):598-609 - PubMed
  47. J Biomed Mater Res A. 2015 Jun;103(6):1974-84 - PubMed
  48. Front Microbiol. 2016 Aug 17;7:1260 - PubMed
  49. Adv Mater. 2013 Dec 10;25(46):6730-6 - PubMed
  50. Arch Intern Med. 1991 May;151(5):886-95 - PubMed
  51. Biomacromolecules. 2012 Oct 8;13(10):3343-54 - PubMed
  52. Chem Soc Rev. 2012 May 21;41(10):3742-52 - PubMed
  53. Langmuir. 2006 Sep 26;22(20):8607-13 - PubMed
  54. Langmuir. 2006 Nov 21;22(24):9820-3 - PubMed
  55. Biomaterials. 2009 Oct;30(28):4921-9 - PubMed
  56. Mar Drugs. 2017 Jun 08;15(6):null - PubMed
  57. Langmuir. 2007 Aug 14;23(17):8670-3 - PubMed
  58. Trends Biotechnol. 2012 Oct;30(10):499-511 - PubMed
  59. J Biomed Mater Res. 2000 Dec 15;52(4):662-8 - PubMed
  60. Curr Opin Microbiol. 2015 Oct;27:1-9 - PubMed
  61. ACS Appl Mater Interfaces. 2017 May 3;9(17):14656-14664 - PubMed
  62. Curr Opin Microbiol. 2011 Oct;14(5):519-23 - PubMed
  63. Colloids Surf B Biointerfaces. 2010 Sep 1;79(2):460-6 - PubMed
  64. Langmuir. 2011 Jun 21;27(12):7828-35 - PubMed
  65. ACS Appl Mater Interfaces. 2012 Jan;4(1):460-5 - PubMed
  66. Nanomaterials (Basel). 2017 Feb 22;7(2): - PubMed
  67. Colloids Surf B Biointerfaces. 2015 Feb 1;126:162-8 - PubMed
  68. J Colloid Interface Sci. 2019 Jan 1;533:604-611 - PubMed
  69. ACS Appl Mater Interfaces. 2017 Jun 7;9(22):18512-18520 - PubMed
  70. ACS Nano. 2010 Jul 27;4(7):3993-4000 - PubMed
  71. Molecules. 2015 Oct 23;20(10):19330-42 - PubMed
  72. J Am Chem Soc. 2016 Feb 24;138(7):2064-77 - PubMed
  73. Biomacromolecules. 2015 Sep 14;16(9):2776-86 - PubMed
  74. Colloids Surf B Biointerfaces. 2019 Apr 1;176:379-386 - PubMed
  75. Biomaterials. 2005 Dec;26(34):6984-90 - PubMed
  76. Biomacromolecules. 2012 Oct 8;13(10):3334-42 - PubMed
  77. Carbohydr Polym. 2017 Oct 15;174:999-1017 - PubMed
  78. Burns Trauma. 2018 May 21;6:16 - PubMed
  79. Biotechnol Bioeng. 2002 Aug 20;79(4):465-71 - PubMed
  80. Int J Mol Sci. 2014 Nov 13;15(11):20800-32 - PubMed
  81. Expert Rev Anti Infect Ther. 2011 Nov;9(11):1035-52 - PubMed
  82. Biotechnol Adv. 2009 Jan-Feb;27(1):76-83 - PubMed
  83. Biomaterials. 2006 Apr;27(11):2495-501 - PubMed
  84. Adv Healthc Mater. 2014 Dec;3(12):1969-85 - PubMed
  85. Carbohydr Polym. 2013 Feb 15;92(2):1012-7 - PubMed
  86. J Agric Food Chem. 2013 Jan 9;61(1):260-7 - PubMed
  87. ACS Appl Mater Interfaces. 2011 Aug;3(8):2845-50 - PubMed
  88. PLoS Med. 2016 Sep 12;13(9):e1002130 - PubMed
  89. Biotechnol Bioeng. 2005 Jun 20;90(6):715-22 - PubMed
  90. J Colloid Interface Sci. 2011 May 15;357(2):354-65 - PubMed
  91. Curr Opin Crit Care. 2015 Oct;21(5):402-11 - PubMed
  92. RSC Adv. 2015 Jan 1;5(24):18881-18887 - PubMed
  93. Lancet Infect Dis. 2012 Mar;12(3):249-53 - PubMed
  94. Biomater Sci. 2016 May 26;4(5):871-9 - PubMed
  95. ACS Appl Mater Interfaces. 2009 Sep;1(9):2049-54 - PubMed
  96. ACS Appl Mater Interfaces. 2014 Sep 24;6(18):15813-21 - PubMed
  97. Biomater Sci. 2016 Aug 19;4(8):1161-83 - PubMed
  98. ACS Nano. 2009 Dec 22;3(12):3891-902 - PubMed
  99. Nanomedicine. 2011 Dec;7(6):935-44 - PubMed
  100. Appl Environ Microbiol. 2016 Feb 12;82(7):2219-26 - PubMed
  101. Int J Biol Sci. 2009;5(2):153-60 - PubMed
  102. Colloids Surf B Biointerfaces. 2010 Mar 1;76(1):248-58 - PubMed
  103. ACS Appl Mater Interfaces. 2017 Nov 8;9(44):38288-38303 - PubMed
  104. Can J Microbiol. 2014 Oct;60(10):629-38 - PubMed
  105. Adv Colloid Interface Sci. 2011 Aug 10;166(1-2):119-35 - PubMed
  106. Microbiology. 2005 May;151(Pt 5):1341-1348 - PubMed
  107. J Agric Food Chem. 2015 Apr 29;63(16):4243-51 - PubMed
  108. Nanoscale. 2014;6(3):1879-89 - PubMed
  109. Int J Pharm. 2017 Aug 7;528(1-2):55-61 - PubMed
  110. Adv Healthc Mater. 2012 Sep;1(5):609-20 - PubMed
  111. Langmuir. 2010 Apr 20;26(8):5901-8 - PubMed
  112. Mol Pharm. 2015 May 4;12(5):1573-83 - PubMed
  113. Ind Eng Chem Res. 2006;45(8):2634-2640 - PubMed
  114. Langmuir. 2011 Apr 5;27(7):4091-7 - PubMed
  115. Trends Biotechnol. 2007 Dec;25(12):547-55 - PubMed
  116. Adv Mater. 2010 Sep 15;22(35):3906-24 - PubMed
  117. J Mater Sci Mater Med. 2010 Oct;21(10):2861-8 - PubMed
  118. Pathog Dis. 2016 Jul;74(5): - PubMed
  119. J Periodontal Res. 2005 Oct;40(5):373-7 - PubMed

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