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Curto S, Aklan B, Mulder T, et al. Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom. Cancers (Basel). 2019;11(11)doi: 10.3390/cancers11111709.
Curto, S., Aklan, B., Mulder, T., Mils, O., Schmidt, M., Lamprecht, U., Peller, M., Wessalowski, R., Lindner, L. H., Fietkau, R., Zips, D., Bellizzi, G. G., van Holthe, N., Franckena, M., Paulides, M. M., & van Rhoon, G. C. (2019). Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom. Cancers, 11(11), . https://doi.org/10.3390/cancers11111709
Curto, Sergio, et al. "Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom." Cancers vol. 11,11 (2019). doi: https://doi.org/10.3390/cancers11111709
Curto S, Aklan B, Mulder T, Mils O, Schmidt M, Lamprecht U, Peller M, Wessalowski R, Lindner LH, Fietkau R, Zips D, Bellizzi GG, van Holthe N, Franckena M, Paulides MM, van Rhoon GC. Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom. Cancers (Basel). 2019 Nov 02;11(11). doi: 10.3390/cancers11111709. PMID: 31684057; PMCID: PMC6896203.
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Cancers (Basel). 2019 Nov 02;11(11). doi: 10.3390/cancers11111709.

Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom.

Cancers

Sergio Curto, Bassim Aklan, Tim Mulder, Oliver Mils, Manfred Schmidt, Ulf Lamprecht, Michael Peller, Ruediger Wessalowski, Lars H Lindner, Rainer Fietkau, Daniel Zips, Gennaro G Bellizzi, Netteke van Holthe, Martine Franckena, Margarethus M Paulides, Gerard C van Rhoon

Affiliations

  1. Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands. [email protected].
  2. Department of Internal Medicine III, Ludwig-Maximilians University Hospital, 81377 Munich, Germany. [email protected].
  3. Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands. [email protected].
  4. Department of Paediatric Haematology and Oncology, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany. [email protected].
  5. Department of Radiation Oncology, University Hospital Erlangen, 91054 Erlangen, Germany. [email protected].
  6. Department of Radiation Oncology, University Hospital Tübingen, 72076 Tübingen, Germany. [email protected].
  7. Department of Radiology, Ludwig-Maximilians University Hospital, 81377 Munich, Germany. [email protected].
  8. Department of Paediatric Haematology and Oncology, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany. [email protected].
  9. Department of Internal Medicine III, Ludwig-Maximilians University Hospital, 81377 Munich, Germany. [email protected].
  10. Department of Radiation Oncology, University Hospital Erlangen, 91054 Erlangen, Germany. [email protected].
  11. Department of Radiation Oncology, University Hospital Tübingen, 72076 Tübingen, Germany. [email protected].
  12. Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands. [email protected].
  13. Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands. [email protected].
  14. Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands. [email protected].
  15. Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands. [email protected].
  16. Center for Care and Cure Technologies Eindhoven (C3Te), Department of Electrical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands. [email protected].
  17. Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands. [email protected].

PMID: 31684057 PMCID: PMC6896203 DOI: 10.3390/cancers11111709

Abstract

Clinical outcome of hyperthermia depends on the achieved target temperature, therefore target conformal heating is essential. Currently, invasive temperature probe measurements are the gold standard for temperature monitoring, however, they only provide limited sparse data. In contrast, magnetic resonance thermometry (MRT) provides unique capabilities to non-invasively measure the 3D-temperature. This study investigates MRT accuracy for MR-hyperthermia hybrid systems located at five European institutions while heating a centric or eccentric target in anthropomorphic phantoms with pelvic and spine structures. Scatter plots, root mean square error (RMSE) and Bland-Altman analysis were used to quantify accuracy of MRT compared to high resistance thermistor probe measurements. For all institutions, a linear relation between MRT and thermistor probes measurements was found with

Keywords: anthropomorphic phantom; magnetic resonance imaging-guided hyperthermia; magnetic resonance thermometry; quality assurance; radiofrequency hyperthermia; thermistor probe

Conflict of interest statement

Dr. Curto reports grants from Pyrexar Medical Corp., grants from COST, during the conduct of the study; Mr. Mulder reports grants from Dutch Cancer Society, during the conduct of the study; Mr. Lampre

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