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Gomes-Santos JAF, Lambertucci RH, Vardaris CV, et al. Early Signs of Inflammation With Mild Oxidative Stress in Mixed Martial Arts Athletes After Simulated Combat. J Strength Cond Res. 2019;doi: 10.1519/JSC.0000000000003383.
Gomes-Santos, J. A. F., Lambertucci, R. H., Vardaris, C. V., Passos, M. E. P., Silva-Junior, E. P., Hatanaka, E., Gorjão, R., McAnulty, S. R., Souza-Junior, T. P., & Barros, M. P. (2019). Early Signs of Inflammation With Mild Oxidative Stress in Mixed Martial Arts Athletes After Simulated Combat. Journal of strength and conditioning research, . https://doi.org/10.1519/JSC.0000000000003383
Gomes-Santos, José Alberto Fernandes, et al. "Early Signs of Inflammation With Mild Oxidative Stress in Mixed Martial Arts Athletes After Simulated Combat." Journal of strength and conditioning research vol. (2019). doi: https://doi.org/10.1519/JSC.0000000000003383
Gomes-Santos JAF, Lambertucci RH, Vardaris CV, Passos MEP, Silva-Junior EP, Hatanaka E, Gorjão R, McAnulty SR, Souza-Junior TP, Barros MP. Early Signs of Inflammation With Mild Oxidative Stress in Mixed Martial Arts Athletes After Simulated Combat. J Strength Cond Res. 2019 Nov 07; doi: 10.1519/JSC.0000000000003383. Epub 2019 Nov 07. PMID: 31714459.
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J Strength Cond Res. 2019 Nov 07; doi: 10.1519/JSC.0000000000003383. Epub 2019 Nov 07.

Early Signs of Inflammation With Mild Oxidative Stress in Mixed Martial Arts Athletes After Simulated Combat.

Journal of strength and conditioning research

José Alberto Fernandes Gomes-Santos, Rafael Herlich Lambertucci, Cristina Vasconcelos Vardaris, Maria Elizabeth Pereira Passos, Edenilson Pinto Silva-Junior, Elaine Hatanaka, Renata Gorjão, Steven Roy McAnulty, Tácito Pessoa Souza-Junior, Marcelo Paes de Barros

Affiliations

  1. Program in Health Sciences, Institute of Physical Activity and Sports Science (ICAFE), Cruzeiro do Sul University, São Paulo, SP, Brazil.
  2. Department of Human Movement Sciences, Institute for Health and Society, Federal University of São Paulo (UNIFESP), Santos, São Paulo, Brazil.
  3. Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina.
  4. Department of Physical Education, Federal University of Parana (UFPR), Curitiba, Puerto Rico, Brazil.

PMID: 31714459 DOI: 10.1519/JSC.0000000000003383

Abstract

Gomes-Santos, JAF, Lambertucci, RH, Vardaris, CV, Passos, MEP, Silva-Junior, EP, Hatanaka, E, Gorjão, R, McAnulty, SR, Souza-Junior, TP, and Barros, MP. Early signs of inflammation with mild oxidative stress in Mixed Martial Arts athletes after simulated combat. J Strength Cond Res XX(X): 000-000, 2019-Combat sports involve a combination of strenuous physical activity, usually at the anaerobic threshold, followed by intermittent low-intensity recovery periods for energy re-establishment. Oxidative stress and inflammation are inevitable exercise-related processes that could drastically affect athletic performance and practitioners' health, unless efficiently controlled during and after physical activities. This study aims to measure oxidative stress and inflammation biomarkers in the plasma of 12 top ranked professional Mixed Martial Arts (MMAs) athletes before and after simulated combats under official rules (pre-post study). Our results show that the athletes exhibited mild oxidative imbalances in plasma, evidenced by significant (p < 0.01) higher contents of both reduced (+7.3%) and oxidized glutathione (+28%), uric acid (+21%), and "free" iron (+21%) after combat, whereas variation tendencies (0.05 < p < 0.01) were observed in the antioxidant capacity in plasma (-40%), and SOD (-27%) or GPX (+20%) antioxidant activities in erythrocytes. However, a clear pro-inflammatory state was detected by increases in circulating cytokines IL-6 (+6,020%), IL-1β (+4,357%), and tumor necrosis factor alpha (+63%), and by an abrupt drop of the anti-inflammatory cytokine IL-10 (-98%). A significant correlation was observed between pre-post variations of IL-6 and GSH/GSSG ratio in plasma (p < 0.0001), which reinforces the integration between oxidative stress and inflammation during MMA combats. Considering metabolic and mechanical stresses (imposed by combat techniques, e.g., punches and joint locks), this study indicates pre-existing inflammation, although minor oxidative stress, in MMA professionals after combat.

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