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Microorganisms. 2019 Nov 11;7(11). doi: 10.3390/microorganisms7110550.

The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions.

Microorganisms

Samantha R Ellis, Mimi Nguyen, Alexandra R Vaughn, Manisha Notay, Waqas A Burney, Simran Sandhu, Raja K Sivamani

Affiliations

  1. PotozkinMD Skincare Center, Danville, CA 94526, USA.
  2. Department of Dermatology, University of California-Davis, Sacramento, CA 95816, USA.
  3. School of Medicine, University of California-Davis, Sacramento, CA 95817, USA.
  4. Department of Biological Sciences, California State University, Sacramento, CA 95819, USA.
  5. College of Medicine, California Northstate University, Elk Grove, CA 95757, USA.
  6. Pacific Skin Institute, Sacramento, CA 95815, USA.
  7. Zen Dermatology, Sacramento, CA 95819, USA.

PMID: 31717915 PMCID: PMC6920876 DOI: 10.3390/microorganisms7110550

Abstract

Microorganisms inhabit various areas of the body, including the gut and skin, and are important in maintaining homeostasis. Changes to the normal microflora due to genetic or environmental factors can contribute to the development of various disease states. In this review, we will discuss the relationship between the gut and skin microbiome and various dermatological diseases including acne, psoriasis, rosacea, and atopic dermatitis. In addition, we will discuss the impact of treatment on the microbiome and the role of probiotics.

Keywords: acne; atopic dermatitis; gut; microbiome; psoriasis; rosacea; skin

References

  1. Curr Opin Allergy Clin Immunol. 2007 Oct;7(5):413-7 - PubMed
  2. J Drugs Dermatol. 2015 Dec;14(12):1400-5 - PubMed
  3. Nephrol Dial Transplant. 2015 Feb;30(2):266-74 - PubMed
  4. J Physiol Paris. 2000 Mar-Apr;94(2):139-52 - PubMed
  5. J Eur Acad Dermatol Venereol. 2000 Sep;14(5):424-5 - PubMed
  6. Int J Mol Sci. 2016 Nov 09;17(11): - PubMed
  7. Microbiol Immunol. 2016 Aug;60(8):521-6 - PubMed
  8. Ann Rheum Dis. 2015 Jan;74(1):303-10 - PubMed
  9. Int J Dermatol. 2016 May;55(5):494-504 - PubMed
  10. PLoS One. 2016 Nov 3;11(11):e0166026 - PubMed
  11. J Physiol Pharmacol. 1999 Dec;50(5):777-86 - PubMed
  12. J Dermatol. 1977 Oct;4(5):193-202 - PubMed
  13. Microbiome. 2013 Dec 23;1(1):31 - PubMed
  14. MBio. 2012 Sep 25;3(5):null - PubMed
  15. J Dermatol. 1994 Jul;21(7):453-60 - PubMed
  16. J Allergy Clin Immunol. 2016 Mar;137(3):852-60 - PubMed
  17. J Dermatol. 2000 May;27(5):318-23 - PubMed
  18. Exp Dermatol. 2012 Dec;21(12):906-10 - PubMed
  19. Int J Dermatol. 1997 Sep;36(9):653-7 - PubMed
  20. Arch Dermatol. 2007 Feb;143(2):239-42 - PubMed
  21. Rev Esp Enferm Dig. 2006 Jul;98(7):501-9 - PubMed
  22. PLoS One. 2011 Feb 24;6(2):e16594 - PubMed
  23. Curr Med Chem. 2019;26(19):3567-3583 - PubMed
  24. Appl Environ Microbiol. 1979 Oct;38(4):585-9 - PubMed
  25. Int J Dermatol. 1990 Oct;29(8):579-82 - PubMed
  26. Biomed Res Int. 2013;2013:918320 - PubMed
  27. Clin Microbiol Infect. 2012 Oct;18(10):1020-5 - PubMed
  28. J Dermatol. 2000 Aug;27(8):519-22 - PubMed
  29. Chin Med J (Engl). 2017 Jul 20;130(14):1662-1669 - PubMed
  30. J Invest Dermatol. 2013 Sep;133(9):2152-60 - PubMed
  31. ISME J. 2008 Jul;2(7):716-27 - PubMed
  32. Curr Allergy Asthma Rep. 2015 Nov;15(11):65 - PubMed
  33. Science. 2009 May 29;324(5931):1190-2 - PubMed
  34. Eur J Dermatol. 2017 Jun 1;27(S1):4-7 - PubMed
  35. Clin Microbiol Infect. 2009 Mar;15(3):238-44 - PubMed
  36. Lipids. 2015 Feb;50(2):121-9 - PubMed
  37. J Ren Nutr. 2015 Nov;25(6):459-65 - PubMed
  38. Gut. 2018 Nov;67(11):1974-1983 - PubMed
  39. Science. 2012 Aug 31;337(6098):1115-9 - PubMed
  40. Atherosclerosis. 2009 Feb;202(2):382-93 - PubMed
  41. Mycopathologia. 2017 Jun;182(5-6):583-589 - PubMed
  42. Exp Dermatol. 2018 Feb;27(2):144-149 - PubMed
  43. Exp Dermatol. 2018 Jan;27(1):37-42 - PubMed
  44. Kathmandu Univ Med J (KUMJ). 2012 Oct-Dec;10(40):49-52 - PubMed
  45. J Allergy Clin Immunol. 2012 Feb;129(2):434-40, 440.e1-2 - PubMed
  46. J Invest Dermatol. 1973 Feb;60(2):94-7 - PubMed
  47. J Am Acad Dermatol. 2016 Sep;75(3):481-493.e8 - PubMed
  48. Nat Rev Microbiol. 2013 Apr;11(4):227-38 - PubMed
  49. Front Cell Infect Microbiol. 2017 Sep 06;7:392 - PubMed
  50. J Eur Acad Dermatol Venereol. 2010 Apr;24(4):410-4 - PubMed
  51. PLoS Biol. 2007 Jul;5(7):e177 - PubMed
  52. Cell. 2018 Feb 8;172(4):784-796.e18 - PubMed
  53. Int J Dermatol. 2003 Aug;42(8):601-4 - PubMed
  54. Sci Rep. 2015 Nov 13;5:16643 - PubMed
  55. Sci Rep. 2018 Feb 28;8(1):3812 - PubMed
  56. PLoS One. 2010 Aug 19;5(8):e12277 - PubMed
  57. Nature. 2015 Apr 2;520(7545):104-8 - PubMed
  58. Am J Clin Dermatol. 2017 Dec;18(6):721-732 - PubMed
  59. J Allergy Clin Immunol. 2001 Oct;108(4):651-2 - PubMed
  60. J Am Acad Dermatol. 2015 May;72(5):749-58; quiz 759-60 - PubMed
  61. Nature. 2006 Dec 21;444(7122):1022-3 - PubMed
  62. Photodermatol. 1989 Apr;6(2):80-4 - PubMed
  63. J Clin Microbiol. 2008 Oct;46(10):3355-60 - PubMed
  64. Clin Exp Allergy. 2004 Jan;34(1):38-43 - PubMed
  65. Br J Dermatol. 2006 Oct;155(4):680-7 - PubMed
  66. Appl Environ Microbiol. 2015 Jun;81(11):3655-62 - PubMed
  67. J Am Acad Dermatol. 1993 May;28(5 Pt 1):719-23 - PubMed
  68. J Clin Microbiol. 2005 Jan;43(1):326-34 - PubMed
  69. J Gen Microbiol. 1968 Feb;50(2):313-20 - PubMed
  70. Curr Opin Lipidol. 2002 Feb;13(1):61-7 - PubMed
  71. Acta Derm Venereol. 2018 Apr 16;98(4):428-436 - PubMed
  72. Br J Nutr. 2012 Jan;107(1):1-6 - PubMed
  73. J Am Acad Dermatol. 2017 Sep;77(3):441-447.e6 - PubMed
  74. PLoS One. 2016 Jul 19;11(7):e0159539 - PubMed
  75. Int J Cancer. 1995 Jan 27;60(3):400-6 - PubMed
  76. BMC Res Notes. 2014 Mar 20;7:166 - PubMed
  77. J Allergy Clin Immunol. 2011 Nov;128(5):948-55.e1-3 - PubMed
  78. J Rheumatol. 2010 Oct;37(10):2118-25 - PubMed
  79. Curr Opin Immunol. 2001 Dec;13(6):701-8 - PubMed
  80. Br J Dermatol. 2017 Feb;176(2):439-445 - PubMed
  81. J Allergy Clin Immunol. 2017 Jan;139(1):166-172 - PubMed
  82. Clin Microbiol Infect. 2018 Nov;24(11):1149-1155 - PubMed
  83. Ann Dermatol Venereol. 2007 Nov;134(11):823-8 - PubMed
  84. Br J Dermatol. 2002 Jul;147(1):55-61 - PubMed
  85. Pediatrics. 2009 May;123(5):e808-14 - PubMed
  86. J Allergy Clin Immunol. 2016 Apr;137(4):1272-1274.e3 - PubMed
  87. Sci Transl Med. 2017 Jul 5;9(397): - PubMed
  88. Dermatology. 1999;199(3):231-6 - PubMed
  89. N Engl J Med. 2005 May 5;352(18):1899-912 - PubMed
  90. Cell Host Microbe. 2008 Apr 17;3(4):213-23 - PubMed
  91. Nature. 2009 Jan 22;457(7228):480-4 - PubMed
  92. Atherosclerosis. 2014 May;234(1):65-72 - PubMed
  93. Science. 2005 Mar 25;307(5717):1915-20 - PubMed
  94. Int Arch Allergy Immunol. 2006;140(2):157-63 - PubMed
  95. J Microbiol Methods. 2014 Jun;101:63-6 - PubMed
  96. Appl Microbiol Biotechnol. 2014 Jan;98(1):411-24 - PubMed
  97. Br J Dermatol. 1998 Jun;138(6):1022-9 - PubMed
  98. J Allergy Clin Immunol. 2008 Jan;121(1):129-34 - PubMed
  99. Ann Nutr Metab. 2015;66 Suppl 1:8-16 - PubMed
  100. Genome Med. 2016 Apr 20;8(1):42 - PubMed
  101. J Am Acad Dermatol. 2011 Jan;64(1):49-52 - PubMed
  102. East Mediterr Health J. 2003 Jan-Mar;9(1-2):167-71 - PubMed
  103. GMS Hyg Infect Control. 2014 Sep 30;9(3):Doc23 - PubMed
  104. J Med Microbiol. 2012 Nov;61(Pt 11):1504-10 - PubMed
  105. J Eur Acad Dermatol Venereol. 2002 Jul;16(4):328-33 - PubMed
  106. Br J Dermatol. 2007 Sep;157(3):474-81 - PubMed
  107. J Am Acad Dermatol. 2013 Dec;69(6):1025-32 - PubMed
  108. Ann Dermatol. 2014 Oct;26(5):598-602 - PubMed
  109. J Allergy Clin Immunol. 2008 Jan;121(1):116-121.e11 - PubMed
  110. J Am Acad Dermatol. 1999 Mar;40(3):433-5 - PubMed
  111. Clin Exp Allergy. 1999 Mar;29(3):342-6 - PubMed
  112. Clin Sci (Lond). 2001 Jan;100(1):91-100 - PubMed
  113. Nature. 2012 Sep 13;489(7415):220-30 - PubMed
  114. PLoS One. 2008 Jul 23;3(7):e2719 - PubMed
  115. Diabetes. 2007 Jul;56(7):1761-72 - PubMed
  116. Pediatr Allergy Immunol. 2012 Nov;23(7):674-81 - PubMed
  117. N Engl J Med. 2008 Apr 3;358(14):1483-94 - PubMed
  118. Gut. 2007 May;56(5):661-7 - PubMed
  119. Epidemiology. 2012 May;23(3):402-14 - PubMed
  120. Int J Mol Sci. 2017 Dec 08;18(12):null - PubMed
  121. J Drugs Dermatol. 2014 Nov;13(11):1365-72 - PubMed
  122. Br J Dermatol. 2017 Oct;177(4):967-977 - PubMed
  123. Am J Gastroenterol. 1998 Feb;93(2):220-2 - PubMed
  124. ISRN Nutr. 2013 Jan 02;2013:481651 - PubMed
  125. Neurobiol Stress. 2016 Mar 04;4:23-33 - PubMed
  126. Exp Dermatol. 2017 Sep;26(9):798-803 - PubMed
  127. Sci Rep. 2016 Dec 21;6:39491 - PubMed
  128. Nat Med. 2010 Feb;16(2):228-31 - PubMed
  129. Cell Metab. 2014 Nov 4;20(5):719-730 - PubMed
  130. MBio. 2013 Apr 30;4(3):e00003-13 - PubMed
  131. Epidemiol Rev. 2000;22(2):283-97 - PubMed
  132. Nat Immunol. 2013 Jul;14(7):676-84 - PubMed
  133. Exp Dermatol. 2010 May;19(5):401-5 - PubMed
  134. J Am Acad Dermatol. 2008 Jan;58(1):68-73 - PubMed
  135. J Dermatol. 2016 Aug;43(8):906-11 - PubMed
  136. JAMA Dermatol. 2015 Jun;151(6):670-1 - PubMed
  137. Nat Rev Microbiol. 2011 Apr;9(4):244-53 - PubMed
  138. Science. 2009 Dec 18;326(5960):1694-7 - PubMed
  139. Arch Dermatol. 2010 Aug;146(8):896-902 - PubMed
  140. J Allergy Clin Immunol. 2003 Mar;111(3):587-91 - PubMed
  141. Genome Res. 2012 May;22(5):850-9 - PubMed
  142. Immunology. 2009 Feb;126(2):233-45 - PubMed
  143. Microbiome. 2018 Sep 5;6(1):154 - PubMed
  144. Nat Rev Immunol. 2008 May;8(5):349-61 - PubMed
  145. Circulation. 2016 Jun 14;133(24):2434-46 - PubMed
  146. Am J Gastroenterol. 2010 Nov;105(11):2420-8 - PubMed
  147. J Biol Chem. 2001 Feb 23;276(8):5707-13 - PubMed
  148. Nutrition. 2016 Mar;32(3):289-95 - PubMed
  149. J Med Microbiol. 1979 Feb;12(1):71-82 - PubMed
  150. J Am Acad Dermatol. 2002 Apr;46(4):584-7 - PubMed
  151. J Eur Acad Dermatol Venereol. 2017 Dec;31(12):2010-2015 - PubMed
  152. Front Immunol. 2017 Jul 24;8:823 - PubMed
  153. Br Med Bull. 2016 Dec;120(1):91-99 - PubMed
  154. N Engl J Med. 2002 Oct 10;347(15):1151-60 - PubMed
  155. Sci Transl Med. 2017 Feb 22;9(378): - PubMed
  156. Clin Mol Allergy. 2008 Sep 22;6:11 - PubMed
  157. Dermatology. 2002;205(3):265-70 - PubMed
  158. Diseases. 2018 Jun 02;6(2):null - PubMed
  159. J Clin Aesthet Dermatol. 2013 Feb;6(2):44-9 - PubMed
  160. J Leukoc Biol. 2011 May;89(5):685-95 - PubMed
  161. J Am Acad Dermatol. 2013 Dec;69(6 Suppl 1):S27-35 - PubMed
  162. Br J Dermatol. 2012 Nov;167(5):1032-6 - PubMed
  163. Eur Respir J. 2002 Jun;19(6):1040-6 - PubMed
  164. Future Microbiol. 2017 Nov;12:1413-1425 - PubMed
  165. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14 - PubMed
  166. Science. 2005 Jun 10;308(5728):1635-8 - PubMed
  167. J Invest Dermatol. 1974 Mar;62(3):326-31 - PubMed
  168. J Cutan Pathol. 1998 Nov;25(10):550-2 - PubMed
  169. BMC Genomics. 2016 Feb 29;17:152 - PubMed
  170. Mymensingh Med J. 2009 Jul;18(2):142-7 - PubMed
  171. Genome Res. 2008 Jul;18(7):1043-50 - PubMed
  172. Arthritis Rheumatol. 2015 Jan;67(1):128-39 - PubMed
  173. PLoS One. 2009 Aug 20;4(8):e6669 - PubMed
  174. J Am Acad Dermatol. 2004 Feb;50(2):266-72 - PubMed
  175. Br J Dermatol. 1999 May;140(5):984-5 - PubMed
  176. Nature. 2014 Oct 2;514(7520):59-64 - PubMed
  177. Indian J Dermatol. 2018 Sep-Oct;63(5):386-390 - PubMed

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