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Weinstock G, Gaubatz S. One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB. Mol Cell Oncol. 2019;6(6):e1648026doi: 10.1080/23723556.2019.1648026.
Weinstock, G., & Gaubatz, S. (2019). One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB. Molecular & cellular oncology, 6(6), e1648026. https://doi.org/10.1080/23723556.2019.1648026
Weinstock, Grit, and Gaubatz, Stefan. "One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB." Molecular & cellular oncology vol. 6,6 (2019): e1648026. doi: https://doi.org/10.1080/23723556.2019.1648026
Weinstock G, Gaubatz S. One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB. Mol Cell Oncol. 2019 Aug 09;6(6):e1648026. doi: 10.1080/23723556.2019.1648026. eCollection 2019. PMID: 31692816; PMCID: PMC6816428.
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Mol Cell Oncol. 2019 Aug 09;6(6):e1648026. doi: 10.1080/23723556.2019.1648026. eCollection 2019.

One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB.

Molecular & cellular oncology

Grit Weinstock, Stefan Gaubatz

Affiliations

  1. Theodor Boveri Institute and Comprehensive Cancer Center Mainfranken, Biocenter, University of Wuerzburg, Wuerzburg, Germany.

PMID: 31692816 PMCID: PMC6816428 DOI: 10.1080/23723556.2019.1648026

Abstract

The Hippo pathway plays a major role in regulating organ size during embryogenesis. Loss of Hippo signaling can cause cancer due to unrestricted cell proliferation. Recently we found that Yes-associated protein 1 (YAP1), the major downstream effector of Hippo, promotes mitotic gene expression and proliferation through binding and activating the Myb-MuvB (MMB) complex subunit MYB proto-oncogene like 2 (B-MYB).

© 2019 Taylor & Francis Group, LLC.

Keywords: B-MYB; MuvB; YAP1; cell cycle; enhancer; gene expression

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