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Bravo-San Pedro JM, Sica V, Kroemer G. The elusive "hunger protein": an appetite-stimulatory factor that is overabundant in human obesity. Mol Cell Oncol. 2019;6(6):e1667193doi: 10.1080/23723556.2019.1667193.
Bravo-San Pedro, J. M., Sica, V., & Kroemer, G. (2019). The elusive "hunger protein": an appetite-stimulatory factor that is overabundant in human obesity. Molecular & cellular oncology, 6(6), e1667193. https://doi.org/10.1080/23723556.2019.1667193
Bravo-San Pedro, José Manuel, et al. "The elusive "hunger protein": an appetite-stimulatory factor that is overabundant in human obesity." Molecular & cellular oncology vol. 6,6 (2019): e1667193. doi: https://doi.org/10.1080/23723556.2019.1667193
Bravo-San Pedro JM, Sica V, Kroemer G. The elusive "hunger protein": an appetite-stimulatory factor that is overabundant in human obesity. Mol Cell Oncol. 2019 Oct 15;6(6):e1667193. doi: 10.1080/23723556.2019.1667193. eCollection 2019. PMID: 31692883; PMCID: PMC6816372.
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Mol Cell Oncol. 2019 Oct 15;6(6):e1667193. doi: 10.1080/23723556.2019.1667193. eCollection 2019.

The elusive "hunger protein": an appetite-stimulatory factor that is overabundant in human obesity.

Molecular & cellular oncology

José Manuel Bravo-San Pedro, Valentina Sica, Guido Kroemer

Affiliations

  1. INSERM U1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France.
  2. Team "Metabolism, Cancer & Immunity" labellisée par la Ligue contre le Cancer, Paris, France.
  3. Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
  4. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
  5. Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China.
  6. Cell Biology and Metabolomics platforms, Gustave Roussy Cancer Campus, Villejuif, France.

PMID: 31692883 PMCID: PMC6816372 DOI: 10.1080/23723556.2019.1667193

Abstract

Paradoxically, most if not all previously known appetite-stimulatory hormones are downregulated in human obesity, reflecting failing homeostatic circuitries. Recently, we discovered that acyl-coenzyme-A binding protein/diazepam-binding inhibitor (ACBP/DBI) acts as a lipogenic and appetite stimulator, when systemically injected into mice. ACBP/DBI plasma levels are also elevated in obese subjects, supporting the notion that it may represent the elusive "hunger protein" that explains overeating in human obesity.

© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords: Aging; anorexia; metabolism; obesity

References

  1. J Cell Biol. 2010 Feb 22;188(4):527-36 - PubMed
  2. Nat Rev Drug Discov. 2010 Jun;9(6):447-64 - PubMed
  3. Mol Cell. 2014 Mar 6;53(5):710-25 - PubMed
  4. Oncogene. 2005 Nov 17;24(51):7503-13 - PubMed
  5. Cell Metab. 2015 Jun 2;21(6):805-21 - PubMed
  6. Autophagy. 2010 Jul;6(5):650-1 - PubMed
  7. Nat Rev Mol Cell Biol. 2018 Nov;19(11):731-745 - PubMed
  8. Eur J Pharmacol. 2001 Mar 2;414(2-3):225-31 - PubMed
  9. Cell Metab. 2014 Mar 4;19(3):431-44 - PubMed
  10. Cell Metab. 2019 Oct 1;30(4):754-767.e9 - PubMed

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