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Fisher JN, Kalleda N, Stavropoulou V, et al. The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse Models. Hemasphere. 2019;3(1):e152doi: 10.1097/HS9.0000000000000152.
Fisher, J. N., Kalleda, N., Stavropoulou, V., & Schwaller, J. (2019). The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse Models. HemaSphere, 3(1), e152. https://doi.org/10.1097/HS9.0000000000000152
Fisher, James Neil, et al. "The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse Models." HemaSphere vol. 3,1 (2019): e152. doi: https://doi.org/10.1097/HS9.0000000000000152
Fisher JN, Kalleda N, Stavropoulou V, Schwaller J. The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse Models. Hemasphere. 2019 Jan 30;3(1):e152. doi: 10.1097/HS9.0000000000000152. eCollection 2019 Feb. PMID: 31723801; PMCID: PMC6745939.
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Hemasphere. 2019 Jan 30;3(1):e152. doi: 10.1097/HS9.0000000000000152. eCollection 2019 Feb.

The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse Models.

HemaSphere

James Neil Fisher, Natarajaswamy Kalleda, Vaia Stavropoulou, Juerg Schwaller

Affiliations

  1. Department of Biomedicine, University Children's Hospital of Basel (UKBB), University of Basel, Basel, Switzerland.

PMID: 31723801 PMCID: PMC6745939 DOI: 10.1097/HS9.0000000000000152

Abstract

Acute myeloid leukemia (AML) is a genetically heterogeneous disease driven by a limited number of cooperating mutations. There is a long-standing debate as to whether AML driver mutations occur in hematopoietic stem or in more committed progenitor cells. Here, we review how different mouse models, despite their inherent limitations, have functionally demonstrated that cellular origin plays a critical role in the biology of the disease, influencing clinical outcome. AML driven by potent oncogenes such as mixed lineage leukemia fusions often seem to emerge from committed myeloid progenitors whereas AML without any major cytogenetic abnormalities seem to develop from a combination of preleukemic initiating events arising in the hematopoietic stem cell pool. More refined mouse models may serve as experimental platforms to identify and validate novel targeted therapeutic strategies.

Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

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