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Front Cell Neurosci. 2019 Oct 22;13:480. doi: 10.3389/fncel.2019.00480. eCollection 2019.

Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner.

Frontiers in cellular neuroscience

Jessica Bellmann, Anne Monette, Vadreenath Tripathy, Anna Sójka, Masin Abo-Rady, Antje Janosh, Rajat Bhatnagar, Marc Bickle, Andrew J Mouland, Jared Sterneckert

Affiliations

  1. Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.
  2. Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
  3. Department of Medicine, McGill University, Montreal, QC, Canada.
  4. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
  5. Verge Genomics, San Francisco, CA, United States.

PMID: 31695598 PMCID: PMC6817715 DOI: 10.3389/fncel.2019.00480

Abstract

Amyotrophic lateral sclerosis (ALS) arises from an interplay of genetic mutations and environmental factors. ssRNA viruses are possible ALS risk factors, but testing their interaction with mutations such as in

Copyright © 2019 Bellmann, Monette, Tripathy, Sójka, Abo-Rady, Janosh, Bhatnagar, Bickle, Mouland and Sterneckert.

Keywords: FUS; HIV-1; Zika virus; amyotrophic lateral sclerosis; induced pluripotent stem cells; rabies virus

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