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Figiel S, Bery F, Chantôme A, et al. A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy. Cancers (Basel). 2019;11(11)doi: 10.3390/cancers11111814.
Figiel, S., Bery, F., Chantôme, A., Fontaine, D., Pasqualin, C., Maupoil, V., Domingo, I., Guibon, R., Bruyère, F., Potier-Cartereau, M., Vandier, C., Fromont, G., & Mahéo, K. (2019). A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy. Cancers, 11(11), . https://doi.org/10.3390/cancers11111814
Figiel, Sandy, et al. "A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy." Cancers vol. 11,11 (2019). doi: https://doi.org/10.3390/cancers11111814
Figiel S, Bery F, Chantôme A, Fontaine D, Pasqualin C, Maupoil V, Domingo I, Guibon R, Bruyère F, Potier-Cartereau M, Vandier C, Fromont G, Mahéo K. A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy. Cancers (Basel). 2019 Nov 18;11(11). doi: 10.3390/cancers11111814. PMID: 31752242; PMCID: PMC6896176.
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Cancers (Basel). 2019 Nov 18;11(11). doi: 10.3390/cancers11111814.

A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy.

Cancers

Sandy Figiel, Fanny Bery, Aurélie Chantôme, Delphine Fontaine, Côme Pasqualin, Véronique Maupoil, Isabelle Domingo, Roseline Guibon, Franck Bruyère, Marie Potier-Cartereau, Christophe Vandier, Gaëlle Fromont, Karine Mahéo

Affiliations

  1. Inserm N2C UMR1069, Université de Tours, F-37032 Tours CEDEX 1, France.
  2. Faculté de Pharmacie, Université de Tours, F-37200 Tours, France.
  3. ERL CNRS 7003-EA 7349-Signalisation et transports ioniques membranaires (STIM), 37200 Tours, France.
  4. Departments of Pathology and Urology, CHRU Bretonneau, F-37044 Tours CEDEX 9, France.

PMID: 31752242 PMCID: PMC6896176 DOI: 10.3390/cancers11111814

Abstract

The composition of periprostatic adipose tissue (PPAT) has been shown to play a role in prostate cancer (PCa) progression. We recently reported an inverse association between PCa aggressiveness and elevated PPAT linoleic acid (LA) and eicosapentaenoic acid (EPA) content. In the present study, we identified a new signaling pathway with a positive feedback loop between the epithelial-to-mesenchymal transition (EMT) transcription factor Zeb1 and the Ca

Keywords: Zeb1; calcium; eicosapentaenoic acid; linoleic acid; prostate cancer

Conflict of interest statement

The authors declare no conflicts of interest.

References

  1. Carcinogenesis. 2012 Feb;33(2):260-7 - PubMed
  2. Endocr Relat Cancer. 2016 Nov;23(11):R517-R525 - PubMed
  3. Cancer Res. 2008 Apr 1;68(7):2479-88 - PubMed
  4. Nat Rev Cancer. 2017 Jun;17(6):367-380 - PubMed
  5. Cancer Res. 2013 Aug 1;73(15):4852-61 - PubMed
  6. J Cardiol. 2016 Jan;67(1):22-7 - PubMed
  7. Nat Rev Cancer. 2010 Jun;10(6):415-24 - PubMed
  8. Oncotarget. 2016 Jun 14;7(24):36168-36184 - PubMed
  9. Nat Commun. 2016 Jan 12;7:10230 - PubMed
  10. Br J Cancer. 2009 Dec 15;101(12):1978-85 - PubMed
  11. Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2502-11 - PubMed
  12. J Hum Genet. 2001;46(8):463-70 - PubMed
  13. Mol Cancer Ther. 2006 Nov;5(11):2946-53 - PubMed
  14. Oncotarget. 2016 Mar 29;7(13):16866-78 - PubMed
  15. Lancet. 2008 May 17;371(9625):1710-21 - PubMed
  16. Front Physiol. 2017 Feb 06;8:43 - PubMed
  17. J Am Coll Cardiol. 2011 Nov 8;58(20):2047-67 - PubMed
  18. Am J Pathol. 2019 Jun;189(6):1268-1275 - PubMed
  19. J Urol. 2009 Oct;182(4):1621-7 - PubMed
  20. Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96 - PubMed
  21. Hum Pathol. 2017 Mar;61:26-32 - PubMed
  22. Cell. 2008 Jul 25;134(2):215-30 - PubMed
  23. Circulation. 2014 Oct 28;130(18):1568-78 - PubMed
  24. Mol Cancer. 2011 Jul 27;10:91 - PubMed
  25. Oncotarget. 2015 Jul 10;6(19):17221-36 - PubMed
  26. Oncotarget. 2016 Dec 6;7(49):80554-80567 - PubMed
  27. Nat Rev Cancer. 2010 Mar;10(3):181-93 - PubMed
  28. Cardiovasc Res. 2012 Jun 1;94(3):460-8 - PubMed
  29. Oncogene. 2014 May 1;33(18):2307-16 - PubMed
  30. Arch Biochem Biophys. 2015 Oct 1;583:18-26 - PubMed
  31. Eur J Cancer. 2018 Mar;91:107-115 - PubMed
  32. Oncotarget. 2017 Aug 9;8(58):97703-97726 - PubMed
  33. Recent Pat Anticancer Drug Discov. 2013 Jan 1;8(1):18-26 - PubMed
  34. Curr Cancer Drug Targets. 2011 Nov;11(9):1111-25 - PubMed
  35. Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E640-6 - PubMed
  36. Nat Rev Cancer. 2011 Jul 22;11(8):609-18 - PubMed

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