Display options
Cite
Peramo A, Dumas A, Remita H, et al. Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles. Chem Commun (Camb). 2019;55(100):15121-15124doi: 10.1039/c9cc07803g.
Peramo, A., Dumas, A., Remita, H., Benoît, M., Yen-Nicolay, S., Corre, R., Louzada, R. A., Dupuy, C., Pecnard, S., Lambert, B., Young, J., Desmaële, D., & Couvreur, P. (2019). Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles. Chemical communications (Cambridge, England), 55(100), 15121-15124. https://doi.org/10.1039/c9cc07803g
Peramo, Arnaud, et al. "Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles." Chemical communications (Cambridge, England) vol. 55,100 (2019): 15121-15124. doi: https://doi.org/10.1039/c9cc07803g
Peramo A, Dumas A, Remita H, Benoît M, Yen-Nicolay S, Corre R, Louzada RA, Dupuy C, Pecnard S, Lambert B, Young J, Desmaële D, Couvreur P. Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles. Chem Commun (Camb). 2019 Dec 28;55(100):15121-15124. doi: 10.1039/c9cc07803g. Epub 2019 Nov 29. PMID: 31782421.
Copy Download .nbib Format: NLM
Share it on

Chem Commun (Camb). 2019 Dec 28;55(100):15121-15124. doi: 10.1039/c9cc07803g. Epub 2019 Nov 29.

Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles.

Chemical communications (Cambridge, England)

Arnaud Peramo, Anaëlle Dumas, Hynd Remita, Mireille Benoît, Stephanie Yen-Nicolay, Raphaël Corre, Ruy A Louzada, Corinne Dupuy, Shannon Pecnard, Benoit Lambert, Jacques Young, Didier Desmaële, Patrick Couvreur

Affiliations

  1. Institut Galien Paris-Sud, UMR 8612, CNRS Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie 5 rue Jean-Baptiste Clément, 92290 Chatenay-Malabry, France. [email protected].
  2. Laboratoire de Chimie Physique, UMR 8000-CNRS, Bâtiment 349, Université Paris-Sud, Université Paris-Saclay, Rue Michel Magat, 91400 Orsay, 91405 Orsay, France.
  3. Trans-Prot, UMS IPSIT, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie 5 rue JB Clément, 92296 Châtenay-Malabry, France.
  4. Institut de Cancérologie Gustave Roussy, UMR8200 CNRS, 114 rue Edouard Vaillant, 94805 Villejuif, France.
  5. Hôpital Bicêtre, 78 rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France.

PMID: 31782421 DOI: 10.1039/c9cc07803g

Abstract

We have developed new benign palladium nanoparticles able to catalyze the Suzuki-Miyaura cross-coupling reaction on human thyroglobulin (Tg), a naturally iodinated protein produced by the thyroid gland, in homogenates from patients' tissues. This represents the first example of a chemoselective native protein modification using transition metal nanoobjects in near-organ medium.

Publication Types