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Farries G, Bryan K, McGivney CL, et al. Expression Quantitative Trait Loci in Equine Skeletal Muscle Reveals Heritable Variation in Metabolism and the Training Responsive Transcriptome. Front Genet. 2019;10:1215doi: 10.3389/fgene.2019.01215.
Farries, G., Bryan, K., McGivney, C. L., McGettigan, P. A., Gough, K. F., Browne, J. A., MacHugh, D. E., Katz, L. M., & Hill, E. W. (2019). Expression Quantitative Trait Loci in Equine Skeletal Muscle Reveals Heritable Variation in Metabolism and the Training Responsive Transcriptome. Frontiers in genetics, 101215. https://doi.org/10.3389/fgene.2019.01215
Farries, Gabriella, et al. "Expression Quantitative Trait Loci in Equine Skeletal Muscle Reveals Heritable Variation in Metabolism and the Training Responsive Transcriptome." Frontiers in genetics vol. 10 (2019): 1215. doi: https://doi.org/10.3389/fgene.2019.01215
Farries G, Bryan K, McGivney CL, McGettigan PA, Gough KF, Browne JA, MacHugh DE, Katz LM, Hill EW. Expression Quantitative Trait Loci in Equine Skeletal Muscle Reveals Heritable Variation in Metabolism and the Training Responsive Transcriptome. Front Genet. 2019 Nov 26;10:1215. doi: 10.3389/fgene.2019.01215. eCollection 2019. PMID: 31850069; PMCID: PMC6902038.
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Front Genet. 2019 Nov 26;10:1215. doi: 10.3389/fgene.2019.01215. eCollection 2019.

Expression Quantitative Trait Loci in Equine Skeletal Muscle Reveals Heritable Variation in Metabolism and the Training Responsive Transcriptome.

Frontiers in genetics

Gabriella Farries, Kenneth Bryan, Charlotte L McGivney, Paul A McGettigan, Katie F Gough, John A Browne, David E MacHugh, Lisa Michelle Katz, Emmeline W Hill

Affiliations

  1. UCD School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
  2. UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland.
  3. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
  4. Research and Development, Plusvital Ltd., Dublin, Ireland.

PMID: 31850069 PMCID: PMC6902038 DOI: 10.3389/fgene.2019.01215

Abstract

While over ten thousand genetic loci have been associated with phenotypic traits and inherited diseases in genome-wide association studies, in most cases only a relatively small proportion of the trait heritability is explained and biological mechanisms underpinning these traits have not been clearly identified. Expression quantitative trait loci (eQTL) are subsets of genomic loci shown experimentally to influence gene expression. Since gene expression is one of the primary determinants of phenotype, the identification of eQTL may reveal biologically relevant loci and provide functional links between genomic variants, gene expression and ultimately phenotype. Skeletal muscle (gluteus medius) gene expression was quantified by RNA-seq for 111 Thoroughbreds (47 male, 64 female) in race training at a single training establishment sampled at two time-points: at rest (

Copyright © 2019 Farries, Bryan, McGivney, McGettigan, Gough, Browne, MacHugh, Katz and Hill.

Keywords: RNA sequencing; aerobic metabolism; exercise; expression quantitative trait loci; gene expression; horse

References

  1. BMC Genomics. 2019 Jan 3;20(1):3 - PubMed
  2. Cell Mol Life Sci. 2005 Aug;62(16):1779-83 - PubMed
  3. Database (Oxford). 2011 Nov 13;2011:bar049 - PubMed
  4. Nat Protoc. 2009;4(8):1184-91 - PubMed
  5. J Appl Physiol (1985). 2011 May;110(5):1160-70 - PubMed
  6. Cancer Res. 1998 Jul 15;58(14):3150-3 - PubMed
  7. Comp Biochem Physiol B Biochem Mol Biol. 1999 Jun;123(2):147-54 - PubMed
  8. Hum Mutat. 2006 Aug;27(8):748-59 - PubMed
  9. Physiol Genomics. 2016 Mar;48(3):202-9 - PubMed
  10. Physiol Genomics. 2010 Jan 8;40(2):83-93 - PubMed
  11. Bioinformatics. 2014 Apr 1;30(7):923-30 - PubMed
  12. Physiol Genomics. 2014 Aug 15;46(16):593-601 - PubMed
  13. Dev Biol. 2000 Nov 15;227(2):533-44 - PubMed
  14. Anim Genet. 2012 Apr;43(2):153-62 - PubMed
  15. J Appl Physiol (1985). 2010 Jun;108(6):1487-96 - PubMed
  16. BMC Genomics. 2017 Aug 9;18(1):595 - PubMed
  17. PLoS One. 2017 Nov 30;12(11):e0189001 - PubMed
  18. Diabetologia. 2003 May;46(5):649-58 - PubMed
  19. BMC Genomics. 2019 Jun 24;20(1):518 - PubMed
  20. J Clin Endocrinol Metab. 2011 Feb;96(2):E394-403 - PubMed
  21. Pflugers Arch. 1989 Feb;413(4):343-7 - PubMed
  22. Carcinogenesis. 2017 Oct 1;38(10):994-1003 - PubMed
  23. Biochem Biophys Res Commun. 2005 Sep 2;334(3):939-46 - PubMed
  24. J Cell Sci. 2014 Nov 15;127(Pt 22):4940-53 - PubMed
  25. OMICS. 2012 May;16(5):284-7 - PubMed
  26. Bioinformatics. 2012 May 15;28(10):1353-8 - PubMed
  27. J Biol Chem. 2010 Nov 12;285(46):35624-32 - PubMed
  28. Domest Anim Endocrinol. 2016 Apr;55:41-5 - PubMed
  29. BMC Genomics. 2017 Jul 27;18(1):565 - PubMed
  30. PLoS One. 2012;7(4):e34890 - PubMed
  31. Mar Biotechnol (NY). 2004 Nov-Dec;6(6):527-40 - PubMed
  32. BMC Genomics. 2009 Dec 30;10:638 - PubMed
  33. Obesity (Silver Spring). 2018 Mar;26(3):559-569 - PubMed
  34. Gigascience. 2015 Feb 25;4:7 - PubMed
  35. Biol Open. 2013 Aug 09;2(10):990-7 - PubMed
  36. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7 - PubMed
  37. Biochim Biophys Acta. 2004 Jan 28;1660(1-2):171-99 - PubMed
  38. BMC Genomics. 2015 Nov 23;16:993 - PubMed
  39. J Appl Physiol (1985). 1985 May;58(5):1689-97 - PubMed
  40. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11416-20 - PubMed
  41. Toxicol Lett. 1996 Sep;87(1):1-9 - PubMed
  42. Nat Genet. 2000 May;25(1):25-9 - PubMed
  43. Dev Biol. 2011 May 15;353(2):275-89 - PubMed
  44. Pflugers Arch. 1998 Aug;436(3):391-7 - PubMed
  45. Nucleic Acids Res. 2017 Jan 4;45(D1):D158-D169 - PubMed
  46. Curr Opin Genet Dev. 2008 Oct;18(5):426-34 - PubMed
  47. Diabetes. 2014 Mar;63(3):1154-65 - PubMed
  48. PLoS One. 2017 Nov 30;12(11):e0186247 - PubMed
  49. JIMD Rep. 2018;42:31-36 - PubMed
  50. Nat Genet. 2013 Jun;45(6):580-5 - PubMed
  51. BMC Genomics. 2018 Mar 20;19(1):202 - PubMed
  52. Nat Genet. 2007 Oct;39(10):1217-24 - PubMed
  53. BMC Genomics. 2011 Feb 07;12:98 - PubMed
  54. J Orthop Res. 2009 Apr;27(4):529-35 - PubMed
  55. Biochim Biophys Acta. 2016 Aug;1857(8):1079-1085 - PubMed
  56. J Nutr. 2009 Feb;139(2):199-206 - PubMed
  57. Bioinformatics. 2010 Jan 1;26(1):139-40 - PubMed
  58. BMC Vet Res. 2017 May 3;13(1):121 - PubMed
  59. J Appl Physiol (1985). 2006 Sep;101(3):934-7 - PubMed
  60. Am J Hum Genet. 2008 Mar;82(3):623-30 - PubMed
  61. Anat Rec. 1996 Oct;246(2):195-207 - PubMed
  62. Histochem Cell Biol. 2004 May;121(5):371-6 - PubMed
  63. Gene. 2016 Dec 15;594(2):203-210 - PubMed
  64. Anim Genet. 2017 Oct;48(5):606-610 - PubMed
  65. Nat Med. 2000 Aug;6(8):924-8 - PubMed
  66. BMC Genomics. 2017 Nov 14;18(Suppl 8):817 - PubMed
  67. J Anim Sci. 1978 Aug;47(2):492-6 - PubMed
  68. BMC Genomics. 2010 Jun 23;11:398 - PubMed
  69. Bioinformatics. 2013 Jan 1;29(1):15-21 - PubMed
  70. Mol Cell. 2016 Aug 18;63(4):608-620 - PubMed
  71. Mol Cell. 2014 Feb 20;53(4):645-54 - PubMed
  72. PLoS Genet. 2013;9(8):e1003649 - PubMed
  73. Trends Biochem Sci. 2017 Oct;42(10):824-843 - PubMed
  74. Biochim Biophys Acta. 2014 Oct;1842(10):1896-1902 - PubMed
  75. Nat Genet. 2014 May;46(5):430-7 - PubMed
  76. Genet Sel Evol. 2014 Feb 04;46:9 - PubMed
  77. Vet J. 2002 Nov;164(3):224-34 - PubMed
  78. Equine Vet J Suppl. 2002 Sep;(34):269-74 - PubMed
  79. Vet Clin North Am Equine Pract. 1997 Apr;13(1):169-85 - PubMed
  80. Cell Mol Life Sci. 2006 Jan;63(1):52-9 - PubMed
  81. J Biol Chem. 1997 Aug 8;272(32):19785-93 - PubMed
  82. Sci Rep. 2018 Apr 18;8(1):6167 - PubMed
  83. Pflugers Arch. 2000 Dec;441(2-3):263-74 - PubMed
  84. Trends Genet. 2001 Jul;17(7):388-91 - PubMed
  85. Med Sci Sports Exerc. 2004 Jul;36(7):1212-7 - PubMed
  86. Mol Cell Biochem. 1997 Dec;177(1-2):169-75 - PubMed
  87. Oncogene. 2013 Sep 26;32(39):4602-13 - PubMed
  88. Hum Genet. 2016 Aug;135(8):869-80 - PubMed
  89. Anim Genet. 2019 Dec;50(6):670-685 - PubMed
  90. Equine Vet J Suppl. 1999 Jul;(30):342-4 - PubMed
  91. PLoS One. 2015 Apr 14;10(4):e0123678 - PubMed
  92. Am J Hum Genet. 2004 Dec;75(6):1094-105 - PubMed
  93. Am J Hum Genet. 2001 Feb;68(2):334-46 - PubMed

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