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Abukar Y, Lever N, Pachen M, et al. Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations. Front Physiol. 2019;10:1420doi: 10.3389/fphys.2019.01420.
Abukar, Y., Lever, N., Pachen, M., LeGrice, I. J., & Ramchandra, R. (2019). Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations. Frontiers in physiology, 101420. https://doi.org/10.3389/fphys.2019.01420
Abukar, Yonis, et al. "Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations." Frontiers in physiology vol. 10 (2019): 1420. doi: https://doi.org/10.3389/fphys.2019.01420
Abukar Y, Lever N, Pachen M, LeGrice IJ, Ramchandra R. Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations. Front Physiol. 2019 Nov 22;10:1420. doi: 10.3389/fphys.2019.01420. eCollection 2019. PMID: 31824334; PMCID: PMC6882935.
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Front Physiol. 2019 Nov 22;10:1420. doi: 10.3389/fphys.2019.01420. eCollection 2019.

Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations.

Frontiers in physiology

Yonis Abukar, Nigel Lever, Mridula Pachen, Ian J LeGrice, Rohit Ramchandra

Affiliations

  1. Department of Physiology, University of Auckland, Auckland, New Zealand.
  2. Department of Cardiology, Auckland District Health Board, Auckland, New Zealand.

PMID: 31824334 PMCID: PMC6882935 DOI: 10.3389/fphys.2019.01420

Abstract

Testing new therapies in heart failure (HF) requires a chronic stable model of HF in large animals. Microembolization of the coronary arteries has been used to model HF previously; however, neural control has not been previously explored in this model. Thus the aim of this study was to further characterize neural control in this model of HF. HF was induced by infusion of microspheres (45 micron; 1.3 ml) into the proximal left coronary artery or left descending coronary arteries, with three sequential embolizations over 3 weeks. Twelve to 14 weeks after the final embolization, and when ejection fraction had decreased below 45%, animals were instrumented to record blood pressure and heart rate. Baroreflex control of heart rate was investigated in conscious animals. Additionally, pressure-volume loops were constructed under anesthesia. Embolization-induced HF was associated with a decrease in mean arterial pressure (67 ± 2 vs. 85 ± 4 mmHg,

Copyright © 2019 Abukar, Lever, Pachen, LeGrice and Ramchandra.

Keywords: embolization; heart failure; heart failure model; neural control; sheep

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