Front Bioeng Biotechnol. 2019 Nov 22;7:337. doi: 10.3389/fbioe.2019.00337. eCollection 2019.
Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit.
Frontiers in bioengineering and biotechnology
Cristiana R Carvalho, Joaquim M Oliveira, Rui L Reis
Affiliations
Affiliations
- 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal.
- ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
- The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Guimarães, Portugal.
PMID: 31824934
PMCID: PMC6882937 DOI: 10.3389/fbioe.2019.00337
Abstract
Peripheral nerve repair and regeneration remains among the greatest challenges in tissue engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are capable of some degree of regeneration, frail recovery is seen even when the best microsurgical technique is applied. PNIs are known to be very incapacitating for the patient, due to the deprivation of motor and sensory abilities. Since there is no optimal solution for tackling this problem up to this day, the evolution in the field is constant, with innovative designs of advanced nerve guidance conduits (NGCs) being reported every day. As a basic concept, a NGC should act as a physical barrier from the external environment, concomitantly acting as physical guidance for the regenerative axons across the gap lesion. NGCs should also be able to retain the naturally released nerve growth factors secreted by the damaged nerve stumps, as well as reducing the invasion of scar tissue-forming fibroblasts to the injury site. Based on the neurobiological knowledge related to the events that succeed after a nerve injury, neuronal subsistence is subjected to the existence of an ideal environment of growth factors, hormones, cytokines, and extracellular matrix (ECM) factors. Therefore, it is known that multifunctional NGCs fabricated through combinatorial approaches are needed to improve the functional and clinical outcomes after PNIs. The present work overviews the current reports dealing with the several features that can be used to improve peripheral nerve regeneration (PNR), ranging from the simple use of hollow NGCs to tissue engineered intraluminal fillers, or to even more advanced strategies, comprising the molecular and gene therapies as well as cell-based therapies.
Copyright © 2019 Carvalho, Oliveira and Reis.
Keywords: biomaterials; luminal fillers; nerve guidance conduit; peripheral nerve; tissue engineering
References
- Biomaterials. 2017 Mar;121:83-96 - PubMed
- Mater Sci Eng C Mater Biol Appl. 2018 Feb 1;83:130-142 - PubMed
- Int Rev Neurobiol. 2013;108:59-77 - PubMed
- Neurorehabil Neural Repair. 2016 Jun;30(5):490-6 - PubMed
- Cell Death Dis. 2017 Oct 12;8(10):e3108 - PubMed
- J Hand Surg Eur Vol. 2008 Oct;33(5):581-6 - PubMed
- Science. 1990 Mar 23;247(4949 Pt 1):1446-51 - PubMed
- Brain. 2009 Nov;132(Pt 11):3122-33 - PubMed
- ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37623-37636 - PubMed
- J Biomed Mater Res A. 2009 Jun 15;89(4):1118-24 - PubMed
- Exp Neurol. 2011 Dec;232(2):110-3 - PubMed
- Mol Cell Neurosci. 2012 May;50(1):103-12 - PubMed
- J Control Release. 2019 Feb 28;296:54-67 - PubMed
- PLoS One. 2010 Aug 27;5(8):e12450 - PubMed
- Exp Ther Med. 2018 Aug;16(2):1250-1258 - PubMed
- Biomaterials. 2010 Nov;31(32):8402-9 - PubMed
- Cells Tissues Organs. 2014;200(1):69-77 - PubMed
- Sci Rep. 2018 Nov 13;8(1):16716 - PubMed
- Neurol Res. 2004 Mar;26(2):151-60 - PubMed
- Invest Ophthalmol Vis Sci. 2014 Sep 30;55(11):7029-39 - PubMed
- Plast Reconstr Surg. 2016 Feb;137(2):318e-330e - PubMed
- Biomaterials. 2018 Sep;177:176-185 - PubMed
- Neural Regen Res. 2018 Jul;13(7):1247-1252 - PubMed
- Semin Musculoskelet Radiol. 2010 Nov;14(5):512-22 - PubMed
- J Neural Eng. 2006 Jun;3(2):172-9 - PubMed
- J Biol Chem. 2003 Dec 5;278(49):48907-13 - PubMed
- J Clin Anesth. 2005 Dec;17(8):640-9 - PubMed
- Biofabrication. 2017 Feb 28;9(1):015024 - PubMed
- Front Cell Neurosci. 2019 Jan 11;12:522 - PubMed
- J Tissue Eng Regen Med. 2012 Feb;6(2):113-24 - PubMed
- Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):203-13 - PubMed
- Sci Rep. 2018 May 29;8(1):8316 - PubMed
- J Anat. 2015 Dec;227(6):746-56 - PubMed
- Eur J Neurosci. 2016 Feb;43(3):336-50 - PubMed
- Biomaterials. 2010 Sep;31(27):6987-99 - PubMed
- J Neural Eng. 2013 Feb;10(1):016008 - PubMed
- Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(6):588-610 - PubMed
- J Mech Behav Biomed Mater. 2015 Jan;41:43-55 - PubMed
- Int J Mol Sci. 2017 May 11;18(5):null - PubMed
- J Neurosci Res. 1989 Jul;23(3):282-9 - PubMed
- Nat Commun. 2015 Oct 14;6:8584 - PubMed
- Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17272-7 - PubMed
- J Neurosci. 1986 Jan;6(1):218-33 - PubMed
- Stem Cell Res Ther. 2018 Oct 11;9(1):266 - PubMed
- Biomaterials. 2017 Sep;140:189-200 - PubMed
- Regen Biomater. 2018 Aug;5(4):197-211 - PubMed
- Biomaterials. 2007 Dec;28(34):5068-73 - PubMed
- J Neural Eng. 2018 Oct;15(5):056010 - PubMed
- J Neuroinflammation. 2011 Aug 30;8:109 - PubMed
- Cell Transplant. 2015;24(3):339-47 - PubMed
- J Bone Joint Surg Am. 2012 Nov 21;94(22):2084-91 - PubMed
- Cell Transplant. 2003;12(3):265-77 - PubMed
- Eur J Neurosci. 2016 Feb;43(3):309-17 - PubMed
- Neural Regen Res. 2014 Mar 15;9(6):661-72 - PubMed
- Pediatr Surg Int. 2002 Sep;18(5-6):327-31 - PubMed
- J Plast Reconstr Aesthet Surg. 2008 Jun;61(6):669-75 - PubMed
- World J Stem Cells. 2017 Sep 26;9(9):144-151 - PubMed
- Acta Biomater. 2017 Sep 15;60:220-231 - PubMed
- Biomater Sci. 2018 May 29;6(6):1299-1311 - PubMed
- Acta Biomater. 2019 Jan 1;83:291-301 - PubMed
- J Neurosurg. 2004 Nov;101(5):806-12 - PubMed
- Biomater Sci. 2018 May 1;6(5):1059-1075 - PubMed
- Mol Cell Biol. 2012 Jan;32(2):558-68 - PubMed
- J Anat. 1999 Jan;194 ( Pt 1):1-14 - PubMed
- J Trauma. 1998 Jul;45(1):116-22 - PubMed
- Bull Hosp Jt Dis (2013). 2017 Jan;75(1):57-63 - PubMed
- Stem Cells Int. 2018 Sep 30;2018:8478953 - PubMed
- J Biomed Mater Res A. 2016 Feb;104(2):367-76 - PubMed
- Chin J Traumatol. 2013;16(6):323-9 - PubMed
- PLoS One. 2009 Dec 03;4(12):e8141 - PubMed
- Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011 Oct;25(10):1245-9 - PubMed
- ACS Appl Mater Interfaces. 2014 Jun 25;6(12):9472-80 - PubMed
- J Peripher Nerv Syst. 2007 Jun;12(2):65-82 - PubMed
- Int J Mol Sci. 2018 Aug 28;19(9):null - PubMed
- Mater Sci Eng C Mater Biol Appl. 2018 Jan 1;82:253-264 - PubMed
- J Neurodegener Dis. 2014;2014:369468 - PubMed
- Cytotherapy. 2017 Aug;19(8):916-926 - PubMed
- Brain Res. 2000 Jun 23;868(2):315-28 - PubMed
- Microsurgery. 2014 Mar;34(3):209-16 - PubMed
- J Neurosci Methods. 2010 Feb 15;186(2):202-8 - PubMed
- Exp Neurol. 2019 Sep;319:112817 - PubMed
- J Cell Mol Med. 2019 Apr;23(4):2822-2835 - PubMed
- J Surg Res. 2013 Apr;180(2):e91-7 - PubMed
- Prog Neurobiol. 2007 Jul;82(4):163-201 - PubMed
- Brain Cell Biol. 2006 Jun;35(2-3):187-201 - PubMed
- Neuroscience. 2008 Mar 27;152(3):821-8 - PubMed
- Int Rev Neurobiol. 2009;87:141-72 - PubMed
- Tissue Eng Part B Rev. 2012 Feb;18(1):40-50 - PubMed
- J Cell Biol. 1997 Nov 3;139(3):709-15 - PubMed
- Rejuvenation Res. 2004 Spring;7(1):15-31 - PubMed
- Neural Regen Res. 2019 Jan;14(1):124-131 - PubMed
- Acta Neurochir (Wien). 2018 Aug;160(8):1587-1589 - PubMed
- Carbohydr Polym. 2018 Aug 15;194:225-235 - PubMed
- Nat Neurosci. 2012 Mar 18;15(4):528-36 - PubMed
- Nat Neurosci. 2017 Aug;20(8):1172-1179 - PubMed
- J Comp Neurol. 1983 Aug 20;218(4):460-70 - PubMed
- Tissue Eng Part A. 2015 Dec;21(23-24):2852-64 - PubMed
- Clin Neurophysiol. 2003 Dec;114(12):2434-46 - PubMed
- Biomaterials. 2002 Feb;23(3):841-8 - PubMed
- Acta Biomater. 2017 Jun;55:296-309 - PubMed
- Biomaterials. 2004 May;25(12):2353-61 - PubMed
- Mol Cell Neurosci. 2017 Mar;79:1-11 - PubMed
- Mol Ther. 2014 Mar;22(3):511-521 - PubMed
- Adv Healthc Mater. 2017 Apr;6(7):null - PubMed
- Ann Plast Surg. 2006 Oct;57(4):462-71 - PubMed
- Neurosci Biobehav Rev. 2014 Sep;45:212-32 - PubMed
- Tissue Eng Part A. 2015 Apr;21(7-8):1409-21 - PubMed
- Biomed Res Int. 2014;2014:698256 - PubMed
- Biomaterials. 2019 May;203:86-95 - PubMed
- Mol Neurobiol. 2003 Jun;27(3):277-324 - PubMed
- Microsurgery. 2006;26(2):116-21 - PubMed
- Health Sci Rep. 2018 Oct 31;1(12):e86 - PubMed
- Stem Cells. 2012 Oct;30(10):2261-70 - PubMed
- Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2060-1 - PubMed
- Biochem Biophys Res Commun. 2008 Nov 14;376(2):358-62 - PubMed
- J Neurosurg. 1988 Jan;68(1):117-23 - PubMed
- Front Neurol. 2014 Mar 31;5:40 - PubMed
- J Neurosci. 2006 Jun 14;26(24):6651-60 - PubMed
- Biotechnol J. 2018 Jul;13(7):e1700635 - PubMed
- Trends Neurosci. 2008 Feb;31(2):90-8 - PubMed
- Lancet Neurol. 2014 Sep;13(9):924-35 - PubMed
- Muscle Nerve. 2011 Aug;44(2):221-34 - PubMed
- J Hand Surg Am. 2019 Aug;44(8):700.e1-700.e9 - PubMed
- Ann Anat. 2013 May;195(3):225-30 - PubMed
- Nanomaterials (Basel). 2018 Sep 10;8(9):null - PubMed
- Prog Neurobiol. 2010 Nov;92(3):245-76 - PubMed
- PLoS One. 2018 Jan 2;13(1):e0190358 - PubMed
- Biomaterials. 2016 Jan;76:33-51 - PubMed
- Anat Rec (Hoboken). 2018 Oct;301(10):1646-1656 - PubMed
- World Neurosurg. 2019 Feb;122:692-703.e2 - PubMed
- J Neurosci. 2009 Jun 10;29(23):7450-8 - PubMed
- Acta Biomater. 2013 Aug;9(8):7719-26 - PubMed
- Neuroscience. 2017 Jan 6;340:319-332 - PubMed
- J Control Release. 2013 Dec 28;172(3):841-51 - PubMed
- Int J Biochem Cell Biol. 2017 May;86:67-76 - PubMed
- Annu Rev Biomed Eng. 2010 Aug 15;12:203-31 - PubMed
- Neurol Res. 2018 Dec;40(12):1060-1070 - PubMed
- Cell Transplant. 2009;18(2):145-58 - PubMed
- Nat Rev Mol Cell Biol. 2007 Jan;8(1):23-36 - PubMed
- J Neurosci Res. 2003 Apr 15;72(2):227-38 - PubMed
- Biochem Biophys Res Commun. 2019 Nov 12;519(3):462-468 - PubMed
- Nano Lett. 2017 Jun 14;17(6):3782-3791 - PubMed
- J Peripher Nerv Syst. 2005 Sep;10(3):293-300 - PubMed
- Regen Biomater. 2017 Feb;4(1):21-30 - PubMed
- J Neurosurg. 2018 Feb 9;:1-10 - PubMed
- ACS Appl Mater Interfaces. 2015 Apr 8;7(13):7189-96 - PubMed
- Cell. 2009 Jan 23;136(2):215-33 - PubMed
- J Tissue Eng Regen Med. 2014 May;8(5):377-85 - PubMed
- J Neurosci Methods. 2011 Apr 30;197(2):209-15 - PubMed
- J R Soc Interface. 2011 Feb 6;8(55):153-70 - PubMed
- Pain. 2016 Mar;157(3):729-39 - PubMed
- Prog Brain Res. 2013;207:91-120 - PubMed
- J Exp Orthop. 2018 Jan 5;5(1):2 - PubMed
- Tissue Eng. 2006 Feb;12(2):267-78 - PubMed
- Brain Res. 2000 Jan 31;854(1-2):19-29 - PubMed
- Science. 1993 May 14;260(5110):920-6 - PubMed
- Transl Androl Urol. 2016 Apr;5(2):167-75 - PubMed
- Sci Rep. 2016 Aug 30;6:32184 - PubMed
- Mol Ther. 2015 Mar;23(3):423-33 - PubMed
- Mol Ther. 2008 Mar;16(3):450-7 - PubMed
- J Control Release. 2010 Apr 19;143(2):168-74 - PubMed
- Clin J Pain. 2016 Feb;32(2):122-9 - PubMed
- Biomed Pharmacother. 2018 May;101:682-690 - PubMed
- Biomacromolecules. 2019 Feb 11;20(2):662-673 - PubMed
- Neuroscience. 2011 Dec 29;199:515-22 - PubMed
- Acta Biomater. 2018 Mar 1;68:223-236 - PubMed
- Macromol Biosci. 2018 Dec;18(12):e1800335 - PubMed
- Neural Regen Res. 2017 Dec;12(12):2106-2112 - PubMed
- J Biomed Mater Res B Appl Biomater. 2018 Feb;106(2):787-799 - PubMed
- Adv Healthc Mater. 2017 Dec;6(24):null - PubMed
- Tissue Eng. 2005 Sep-Oct;11(9-10):1611-7 - PubMed
- Hand (N Y). 2015 Jun;10(2):161-7 - PubMed
- J Biomed Mater Res A. 2004 Feb 1;68(2):201-9 - PubMed
- Ann Plast Surg. 2011 Aug;67(2):147-55 - PubMed
- Cytokine. 2017 Oct;98:97-106 - PubMed
- Gene Ther. 2008 Jan;15(2):109-16 - PubMed
- J Biomed Mater Res. 2001 Sep 5;56(3):400-5 - PubMed
- J Biomed Sci. 2015 May 20;22:35 - PubMed
- Phys Ther. 2006 Jan;86(1):92-109 - PubMed
- Int J Mol Sci. 2018 Jul 19;19(7):null - PubMed
- Biochem Soc Trans. 2006 Aug;34(Pt 4):612-7 - PubMed
- Neural Regen Res. 2018 May;13(5):757-763 - PubMed
- J Neurochem. 2012 Aug;122(3):501-11 - PubMed
- Biomed Res Int. 2017;2017:1252851 - PubMed
- Biomaterials. 2013 Sep;34(29):7086-96 - PubMed
- Annu Rev Neurosci. 2015 Jul 8;38:25-46 - PubMed
- Biomaterials. 2005 Dec;26(35):7339-49 - PubMed
- Glia. 2013 Jul;61(7):1029-40 - PubMed
- Cold Spring Harb Perspect Biol. 2015 May 08;7(7):a020487 - PubMed
- Exp Neurol. 1999 Aug;158(2):290-300 - PubMed
- Neural Regen Res. 2015 Apr;10(4):651-8 - PubMed
- J Anat. 2000 Nov;197 Pt 4:591-605 - PubMed
- Int J Nanomedicine. 2017 Oct 24;12:7815-7832 - PubMed
- Cell Transplant. 2016;25(1):159-82 - PubMed
- Exp Neurol. 2006 Jun;199(2):348-53 - PubMed
- Exp Neurol. 2018 Nov;309:79-90 - PubMed
- Dis Model Mech. 2016 Dec 1;9(12):1507-1511 - PubMed
- Genesis. 2014 Apr;52(4):341-9 - PubMed
- Exp Neurol. 2015 Jul;269:93-101 - PubMed
- Trends Cogn Sci. 2017 Mar;21(3):195-204 - PubMed
- Int J Cancer. 2017 Jan 15;140(2):411-422 - PubMed
- J Hand Surg Am. 2000 May;25(3):391-414 - PubMed
- Int J Biol Sci. 2018 Oct 31;14(13):1910-1922 - PubMed
- J Bone Joint Surg Am. 2013 Dec 4;95(23):2144-51 - PubMed
- Exp Neurol. 1982 May;76(2):361-75 - PubMed
- Biofabrication. 2018 Mar 23;10(3):032001 - PubMed
- PLoS One. 2013;8(2):e57000 - PubMed
- J Biomed Mater Res A. 2003 Nov 1;67(2):467-74 - PubMed
- J Hand Surg Am. 2016 Jun;41(6):e113-21 - PubMed
- Transpl Immunol. 2019 Apr;53:61-71 - PubMed
- Brain Res. 2011 Apr 6;1383:62-70 - PubMed
- PLoS One. 2011;6(8):e23423 - PubMed
- Tissue Eng Part A. 2009 Nov;15(11):3297-308 - PubMed
- Adv Healthc Mater. 2018 Sep;7(17):e1800186 - PubMed
- Neurochem Int. 2016 Jul;97:146-53 - PubMed
- Biomaterials. 2008 Jul;29(21):3117-27 - PubMed
- Sci Rep. 2018 Mar 14;8(1):4485 - PubMed
- Cell Transplant. 2018 Jun;27(6):879-889 - PubMed
- Acta Biomater. 2017 Jul 1;56:141-152 - PubMed
- Biochem Biophys Res Commun. 2010 Oct 29;401(4):592-7 - PubMed
- Tissue Eng Part A. 2015 Mar;21(5-6):1152-62 - PubMed
- Eur J Neurosci. 2000 Dec;12(12):4243-54 - PubMed
- Muscle Nerve. 2019 May;59(5):603-610 - PubMed
- J Urol. 2002 Oct;168(4 Pt 2):1789-92; discussion 1792-3 - PubMed
- Biomaterials. 2011 Jun;32(16):3958-68 - PubMed
- Life Sci. 2019 Mar 15;221:99-108 - PubMed
- Exp Neurol. 2018 Jun;304:67-81 - PubMed
- Brain Res Bull. 2010 Oct 30;83(5):207-13 - PubMed
- Nat Rev Neurosci. 2009 Dec;10(12):837-41 - PubMed
- RSC Adv. 2015 Jan 1;5(122):100824-100833 - PubMed
- Biomaterials. 2006 Jul;27(19):3515-8 - PubMed
Publication Types