Display options
Cite
Beaurain M, Salabert AS, Ribeiro MJ, et al. Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience. Front Med (Lausanne). 2019;6:268doi: 10.3389/fmed.2019.00268.
Beaurain, M., Salabert, A. S., Ribeiro, M. J., Arlicot, N., Damier, P., Le Jeune, F., Demonet, J. F., & Payoux, P. (2019). Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience. Frontiers in medicine, 6268. https://doi.org/10.3389/fmed.2019.00268
Beaurain, Marie, et al. "Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience." Frontiers in medicine vol. 6 (2019): 268. doi: https://doi.org/10.3389/fmed.2019.00268
Beaurain M, Salabert AS, Ribeiro MJ, Arlicot N, Damier P, Le Jeune F, Demonet JF, Payoux P. Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience. Front Med (Lausanne). 2019 Nov 27;6:268. doi: 10.3389/fmed.2019.00268. eCollection 2019. PMID: 31828073; PMCID: PMC6890558.
Copy Download .nbib Format: NLM
Share it on

Front Med (Lausanne). 2019 Nov 27;6:268. doi: 10.3389/fmed.2019.00268. eCollection 2019.

Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience.

Frontiers in medicine

Marie Beaurain, Anne-Sophie Salabert, Maria Joao Ribeiro, Nicolas Arlicot, Philippe Damier, Florence Le Jeune, Jean-François Demonet, Pierre Payoux

Affiliations

  1. CHU de Toulouse, Toulouse, France.
  2. ToNIC, Toulouse NeuroImaging Center, Inserm U1214, Toulouse, France.
  3. UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
  4. Inserm CIC 1415, University Hospital, Tours, France.
  5. CHRU Tours, Tours, France.
  6. Inserm U913, Neurology Department, University Hospital, Nantes, France.
  7. Centre Eugène Marquis, Rennes, France.
  8. Leenards Memory Centre, Department of Clinical Neuroscience, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

PMID: 31828073 PMCID: PMC6890558 DOI: 10.3389/fmed.2019.00268

Abstract

Over the past few decades, several radiotracers have been developed for neuroimaging applications, especially in PET. Because of their low steric hindrance, PET radionuclides can be used to label molecules that are small enough to cross the blood brain barrier, without modifying their biological properties. As the use of 11C is limited by its short physical half-life (20 min), there has been an increasing focus on developing tracers labeled with 18F for clinical use. The first such tracers allowed cerebral blood flow and glucose metabolism to be measured, and the development of molecular imaging has since enabled to focus more closely on specific targets such as receptors, neurotransmitter transporters, and other proteins. Hence, PET and SPECT biomarkers have become indispensable for innovative clinical research. Currently, the treatment options for a number of pathologies, notably neurodegenerative diseases, remain only supportive and symptomatic. Treatments that slow down or reverse disease progression are therefore the subject of numerous studies, in which molecular imaging is proving to be a powerful tool. PET and SPECT biomarkers already make it possible to diagnose several neurological diseases

Copyright © 2019 Beaurain, Salabert, Ribeiro, Arlicot, Damier, Le Jeune, Demonet and Payoux.

Keywords: PET; SPECT; clinical research; molecular imaging; neurology; psychiatry

References

  1. Clin Nucl Med. 2015 Feb;40(2):e111-6 - PubMed
  2. Br J Psychiatry. 2008 Sep;193(3):229-34 - PubMed
  3. J Nucl Med. 2010 Dec;51(12):1885-91 - PubMed
  4. Neuroimage. 2006 Nov 1;33(2):423-9 - PubMed
  5. Nucl Med Biol. 2015 Aug;42(8):643-53 - PubMed
  6. Alzheimers Dement. 2015 Aug;11(8):964-74 - PubMed
  7. Bioorg Med Chem. 2004 Jun 15;12(12):3229-37 - PubMed
  8. Neurosci Lett. 2006 Nov 6;408(1):46-50 - PubMed
  9. Epilepsy Res. 2013 Sep;106(1-2):173-80 - PubMed
  10. Neurobiol Dis. 2008 Dec;32(3):412-9 - PubMed
  11. Psychopharmacology (Berl). 2007 Apr;191(3):805-11 - PubMed
  12. Brain. 2016 Apr;139(Pt 4):1252-64 - PubMed
  13. Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S30-45 - PubMed
  14. J Neurosci. 2001 Dec 15;21(24):RC189 - PubMed
  15. Biol Psychiatry. 2010 Jun 1;67(11):1033-9 - PubMed
  16. Brain. 2013 Oct;136(Pt 10):3004-17 - PubMed
  17. Nucl Med Biol. 2018 Jun;61:45-55 - PubMed
  18. JAMA. 2018 Sep 18;320(11):1151-1162 - PubMed
  19. Neurology. 2016 Aug 30;87(9):920-6 - PubMed
  20. Int J Mol Sci. 2017 Apr 07;18(4): - PubMed
  21. Neurology. 2005 Dec 13;65(11):1716-22 - PubMed
  22. Neurology. 2003 Jul 8;61(1):29-34 - PubMed
  23. Mov Disord. 2017 Jul;32(7):1016-1024 - PubMed
  24. Nucl Med Biol. 1994 Aug;21(6):801-8 - PubMed
  25. Psychopharmacology (Berl). 2015 Nov;232(21-22):4129-57 - PubMed
  26. J Alzheimers Dis. 2013;34(2):457-68 - PubMed
  27. Ann Neurol. 2008 Mar;63(3):388-94 - PubMed
  28. Neurology. 2000 Nov 28;55(10):1575-7 - PubMed
  29. EJNMMI Res. 2018 Jul 27;8(1):69 - PubMed
  30. Ann Neurol. 1997 Jan;41(1):17-24 - PubMed
  31. J Nucl Med. 2010 Dec;51(12):1892-900 - PubMed
  32. J Neurochem. 2013 May;125(4):491-511 - PubMed
  33. EJNMMI Res. 2013 Apr 24;3(1):30 - PubMed
  34. Clin Nucl Med. 2014 Jun;39(6):e334-5 - PubMed
  35. J Psychiatr Res. 1997 Nov-Dec;31(6):605-19 - PubMed
  36. Eur J Nucl Med Mol Imaging. 2018 Jun;45(6):1041-1051 - PubMed
  37. Psychopharmacology (Berl). 2007 Sep;193(4):539-45 - PubMed
  38. Clin Neuropharmacol. 2001 Jan-Feb;24(1):43-9 - PubMed
  39. Mol Imaging. 2018 Jan-Dec;17:1536012118792317 - PubMed
  40. Neuropharmacology. 2013 May;68:195-201 - PubMed
  41. N Engl J Med. 2004 Dec 9;351(24):2498-508 - PubMed
  42. J Neural Transm (Vienna). 2007 Mar;114(3):337-40 - PubMed
  43. Mov Disord. 2002 Mar;17(2):303-12 - PubMed
  44. J Neurochem. 2008 Aug;106(3):1371-7 - PubMed
  45. J Nucl Med. 2018 Apr;59(4):682-690 - PubMed
  46. Nucl Med Biol. 2010 May;37(4):413-9 - PubMed
  47. Neuroimage Clin. 2013 Aug 08;3:212-7 - PubMed
  48. J Nucl Med. 2010 Jan;51(1):7-15 - PubMed
  49. J Psychiatr Res. 1985;19(4):609-22 - PubMed
  50. Eur J Nucl Med Mol Imaging. 2006 Jan;33(1):87-92 - PubMed
  51. Mol Imaging. 2018 Jan-Dec;17:1536012118788636 - PubMed
  52. Neuropsychopharmacology. 2004 Dec;29(12):2235-41 - PubMed
  53. Brain. 1997 Dec;120 ( Pt 12):2187-95 - PubMed
  54. Brain. 2004 Apr;127(Pt 4):900-13 - PubMed
  55. Eur J Pharmacol. 1996 Jan 4;295(1):35-44 - PubMed
  56. Nucl Med Biol. 2016 Jul;43(7):438-44 - PubMed
  57. Eur J Nucl Med Mol Imaging. 2015 Jan;42(1):128-37 - PubMed
  58. Am J Psychiatry. 2006 Sep;163(9):1580-7 - PubMed
  59. J Nucl Med. 2017 Jul;58(7):1124-1131 - PubMed
  60. Neuroimage. 2009 Apr 1;45(2):280-5 - PubMed
  61. Biol Psychiatry. 2002 Nov 1;52(9):896-906 - PubMed
  62. J Cereb Blood Flow Metab. 2015 May;35(5):766-72 - PubMed
  63. J Affect Disord. 2003 Apr;74(2):149-58 - PubMed
  64. Neurology. 2014 Nov 4;83(19):1739-46 - PubMed
  65. J Psychopharmacol. 2012 Feb;26(2):273-81 - PubMed
  66. F1000Res. 2018 Jul 31;7: - PubMed
  67. Mol Psychiatry. 2012 Dec;17(12):1254-60 - PubMed
  68. Clin Radiol. 2010 Jul;65(7):500-16 - PubMed
  69. Neurology. 2018 May 29;90(22):e1989-e1996 - PubMed
  70. J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):196-206 - PubMed
  71. Cereb Cortex. 2016 Oct 17;26(11):4170-4179 - PubMed
  72. Int J Neuropsychopharmacol. 2005 Sep;8(3):391-401 - PubMed
  73. Ann Neurol. 1999 Jul;46(1):62-9 - PubMed
  74. Nat Clin Pract Neurol. 2008 May;4(5):267-77 - PubMed
  75. Alzheimers Res Ther. 2014 Feb 26;6(1):11 - PubMed
  76. Am J Psychiatry. 2001 Nov;158(11):1843-9 - PubMed
  77. Exp Brain Res. 1998 May;120(2):257-62 - PubMed
  78. J Med Chem. 1997 Apr 25;40(9):1366-72 - PubMed
  79. Mini Rev Med Chem. 2010 Aug;10(9):870-86 - PubMed
  80. Brain. 2013 Mar;136(Pt 3):844-58 - PubMed
  81. Pharmacol Rev. 1999 Mar;51(1):7-61 - PubMed
  82. ACS Chem Neurosci. 2018 Feb 21;9(2):298-305 - PubMed
  83. Brain. 2017 Dec 1;140(12):3286-3300 - PubMed
  84. J Nucl Med. 1996 Dec;37(12):1976-81 - PubMed
  85. Mol Imaging. 2017 Jan-Dec;16:1536012117731258 - PubMed
  86. Neurobiol Aging. 2008 Aug;29(8):1204-17 - PubMed
  87. Nucl Med Biol. 2013 Oct;40(7):901-5 - PubMed
  88. J Neural Transm (Vienna). 2005 May;112(5):677-92 - PubMed
  89. J Nucl Med. 2014 Mar;55(3):396-404 - PubMed
  90. Synapse. 1999 Mar 1;31(3):178-85 - PubMed
  91. Psychiatry Res. 2009 Sep 30;173(3):212-7 - PubMed
  92. Psychopharmacology (Berl). 2006 Nov;188(4):509-20 - PubMed
  93. Ann Neurol. 2006 Mar;59(3):512-9 - PubMed
  94. J Nucl Med. 2017 Jan;58(1):110-116 - PubMed
  95. J Nucl Med. 2007 Feb;48(2):247-52 - PubMed
  96. J Nucl Med. 2014 Apr;55(4):672-7 - PubMed
  97. Mov Disord. 2018 Apr;33(4):503-510 - PubMed
  98. J Nucl Med. 1990 May;31(5):648-54 - PubMed
  99. J Neurochem. 2005 May;93(4):812-24 - PubMed
  100. Eur J Nucl Med Mol Imaging. 2009 Dec;36(12):2103-10 - PubMed
  101. Synapse. 2003 Mar;47(3):200-8 - PubMed
  102. Brain. 2008 Oct;131(Pt 10):2765-82 - PubMed
  103. Curr Alzheimer Res. 2013 Mar;10(3):217-28 - PubMed
  104. Schizophr Res. 2017 May;183:95-101 - PubMed
  105. J Nucl Med. 2015 Mar;56(3):386-91 - PubMed
  106. J Nucl Med. 2000 Apr;41(4):584-9 - PubMed
  107. Biol Psychiatry. 2006 May 1;59(9):821-8 - PubMed
  108. Psychopharmacology (Berl). 2001 Aug;157(1):60-6 - PubMed
  109. EJNMMI Res. 2017 Oct 26;7(1):89 - PubMed
  110. J Neuroimaging. 2002 Oct;12(4):316-24 - PubMed
  111. Transl Psychiatry. 2017 Jun 6;7(6):e1147 - PubMed
  112. J Nucl Med. 2016 Feb;57(2):242-7 - PubMed
  113. Neurosci Lett. 2005 May 20-27;380(1-2):127-32 - PubMed
  114. J Nucl Med. 2011 Jul;52(7):1094-101 - PubMed
  115. J Nucl Med. 2003 Dec;44(12):1890-7 - PubMed
  116. Ann Neurol. 2010 Mar;67(3):317-24 - PubMed
  117. PLoS One. 2015 Apr 01;10(4):e0121342 - PubMed
  118. Ageing Res Rev. 2017 Jul;36:50-63 - PubMed
  119. J Nucl Med. 2007 Jun;48(6):18N, 21N - PubMed
  120. Neurology. 2007 Sep 4;69(10):1012-7 - PubMed
  121. Anesth Analg. 2003 Oct;97(4):1108-16 - PubMed
  122. Neuroimage. 2008 Aug 1;42(1):306-14 - PubMed
  123. Alzheimer Dis Assoc Disord. 1995 Spring;9(1):21-7 - PubMed
  124. Cephalalgia. 2008 Dec;28(12):1282-91 - PubMed
  125. Nucl Med Biol. 2008 Nov;35(8):869-74 - PubMed
  126. J Nucl Med. 2013 Jul;54(7):1072-6 - PubMed
  127. J Neural Transm Park Dis Dement Sect. 1990;2(3):215-24 - PubMed
  128. Mov Disord. 2007 Aug 15;22(11):1594-600 - PubMed
  129. Eur J Nucl Med Mol Imaging. 2015 Jun;42(7):1052-61 - PubMed
  130. Neuropsychopharmacology. 2008 Sep;33(10):2435-41 - PubMed
  131. Stroke. 2004 Aug;35(8):1892-8 - PubMed
  132. Eur Arch Psychiatry Clin Neurosci. 1990;240(2):121-33 - PubMed
  133. Life Sci. 1996;59(8):669-78 - PubMed
  134. Brain. 2010 Feb;133(Pt 2):512-28 - PubMed
  135. Nucl Med Mol Imaging. 2015 Dec;49(4):251-7 - PubMed
  136. Neurobiol Dis. 2015 Oct;82:526-539 - PubMed
  137. J Med Chem. 1996 Aug 16;39(17):3331-42 - PubMed
  138. Contrast Media Mol Imaging. 2018 Feb 6;2018:9165458 - PubMed
  139. Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1376-86 - PubMed
  140. Ann N Y Acad Sci. 2003 Nov;1003:364-7 - PubMed
  141. Eur J Pharmacol. 2009 Sep 1;617(1-3):54-8 - PubMed
  142. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1308-13 - PubMed
  143. Nature. 1983 Sep 8-14;305(5930):137-8 - PubMed
  144. JACC Basic Transl Sci. 2018 May 30;3(3):378-390 - PubMed
  145. JAMA. 2002 Apr 3;287(13):1653-61 - PubMed
  146. J Nucl Med. 2014 Sep;55(9):1397-400 - PubMed
  147. Ann Nucl Med. 1998 Feb;12(1):35-42 - PubMed
  148. J Nucl Med. 2005 Jun;46(6):973-7 - PubMed
  149. Biol Psychiatry. 2005 Dec 15;58(12):947-54 - PubMed
  150. Alzheimers Dement. 2016 Mar;12(3):292-323 - PubMed
  151. Arch Neurol. 2011 Jul;68(7):905-12 - PubMed
  152. Acta Neuropathol Commun. 2016 Jun 13;4(1):58 - PubMed
  153. Cephalalgia. 1995 Apr;15(2):104-8; discussion 77 - PubMed
  154. Eur J Nucl Med Mol Imaging. 2011 Sep;38(9):1702-14 - PubMed
  155. Semin Nucl Med. 2012 Nov;42(6):423-32 - PubMed
  156. Biol Psychiatry. 2015 Feb 1;77(3):266-275 - PubMed
  157. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8390-8395 - PubMed
  158. Mov Disord. 2016 Jun;31(6):814-29 - PubMed
  159. J Nucl Med. 2017 Feb;58(2):320-325 - PubMed
  160. Mol Pharm. 2018 Aug 6;15(8):3153-3166 - PubMed
  161. Br J Psychiatry. 1998 Sep;173:236-41 - PubMed
  162. J Nucl Med. 2009 Oct;50(10):1638-45 - PubMed
  163. J Nucl Med. 2010 Apr;51(4):588-95 - PubMed
  164. Neurotherapeutics. 2017 Jan;14(1):62-68 - PubMed
  165. Int J Neuropsychopharmacol. 2007 Dec;10(6):777-85 - PubMed
  166. Eur J Nucl Med Mol Imaging. 2004 Dec;31(12):1631-8 - PubMed
  167. J Neural Transm (Vienna). 2007;114(12):1603-9 - PubMed
  168. J Nucl Med. 2016 Oct;57(10):1529-1534 - PubMed
  169. Arch Neurol. 1993 May;50(5):513-6 - PubMed
  170. Nucl Med Biol. 2000 Jul;27(5):493-7 - PubMed
  171. J Med Chem. 1998 Sep 10;41(19):3690-8 - PubMed
  172. J Nucl Med. 2001 Sep;42(9):1303-8 - PubMed
  173. Int J Rad Appl Instrum B. 1989;16(1):51-5 - PubMed
  174. J Neurol Neurosurg Psychiatry. 1998 Aug;65(2):155-63 - PubMed
  175. Alzheimers Dement. 2013 May;9(3):295-301 - PubMed
  176. Am J Psychiatry. 2007 Dec;164(12):1858-65 - PubMed
  177. Brain. 2014 Jun;137(Pt 6):1762-71 - PubMed
  178. J Neurochem. 1998 Oct;71(4):1750-60 - PubMed
  179. Brain. 1993 Jun;116 ( Pt 3):497-510 - PubMed
  180. Biol Psychiatry. 2006 Aug 1;60(3):207-17 - PubMed
  181. Eur Neuropsychopharmacol. 2019 Dec;29(2):278-290 - PubMed
  182. Life Sci. 1988;42(21):2097-104 - PubMed
  183. Neuropharmacology. 2009;56 Suppl 1:3-8 - PubMed
  184. Int J Neuropsychopharmacol. 2007 Apr;10(2):245-52 - PubMed
  185. Nucl Med Biol. 2014 Jan;41(1):106-13 - PubMed
  186. J Neurosci. 2004 Jan 21;24(3):589-91 - PubMed
  187. Curr Alzheimer Res. 2017;14(2):154-160 - PubMed
  188. Epilepsia. 2006 Aug;47(8):1392-6 - PubMed
  189. J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):356-62 - PubMed
  190. Clin Nucl Med. 2018 Sep;43(9):e289-e295 - PubMed
  191. Mol Psychiatry. 2018 Apr;23(4):824-832 - PubMed
  192. J Neurol. 2002 Oct;249 Suppl 3:III/40-8 - PubMed
  193. Neurobiol Aging. 2003 Jul-Aug;24(4):553-61 - PubMed
  194. N Engl J Med. 2018 Jan 25;378(4):321-330 - PubMed
  195. Ann Neurol. 1993 Sep;34(3):324-30 - PubMed
  196. Nucl Med Biol. 1995 Jul;22(5):659-65 - PubMed
  197. J Nucl Med. 2012 Jun;53(6):902-7 - PubMed
  198. Arch Neurol. 2003 Dec;60(12):1745-8 - PubMed
  199. J Neurol. 2007 Jun;254(6):789-96 - PubMed
  200. Lancet Neurol. 2009 Dec;8(12):1150-7 - PubMed
  201. J Neurochem. 2008 May;105(4):1428-37 - PubMed
  202. Int J Rad Appl Instrum A. 1990;41(2):139-42 - PubMed
  203. Neurology. 1998 Feb;50(2):445-54 - PubMed
  204. J Cereb Blood Flow Metab. 1999 Oct;19(10):1150-63 - PubMed
  205. Bioorg Med Chem. 2006 Feb 15;14(4):1115-25 - PubMed
  206. Drug Discov Today. 2013 Feb;18(3-4):173-84 - PubMed
  207. J Neurosci. 2009 Jul 8;29(27):8805-15 - PubMed
  208. Rev Neurol (Paris). 2014 Dec;170(12):739-48 - PubMed
  209. Neurology. 2009 Jul 28;73(4):273-8 - PubMed
  210. Synapse. 2009 Aug;63(8):713-6 - PubMed
  211. Synapse. 2007 Nov;61(11):882-8 - PubMed
  212. Neuropsychopharmacology. 2009 Feb;34(3):624-33 - PubMed
  213. Eur J Nucl Med Mol Imaging. 2006 Feb;33(2):200-9 - PubMed
  214. Brain. 2009 Apr;132(Pt 4):1093-101 - PubMed
  215. Lancet Neurol. 2008 Aug;7(8):742-55 - PubMed
  216. Trends Pharmacol Sci. 2008 Sep;29(9):482-92 - PubMed
  217. PLoS One. 2013;8(2):e55031 - PubMed
  218. J Alzheimers Dis. 2006;9(3 Suppl):417-23 - PubMed
  219. Science. 2010 Sep 24;329(5999):1663-7 - PubMed
  220. Neurology. 2001 May 8;56(9):1143-53 - PubMed
  221. Arch Neurol. 2006 Dec;63(12):1771-6 - PubMed
  222. Int J Neuropsychopharmacol. 2015 Jan 07;18(7):pyu120 - PubMed
  223. Nucl Med Biol. 1995 May;22(4):459-66 - PubMed
  224. Psychopharmacology (Berl). 2006 Oct;188(3):263-72 - PubMed
  225. Brain. 2007 Nov;130(Pt 11):2837-44 - PubMed
  226. Schizophr Res. 2008 Feb;99(1-3):333-40 - PubMed
  227. Brain Struct Funct. 2016 Apr;221(3):1387-402 - PubMed
  228. Nucl Med Biol. 1997 Oct;24(7):615-9 - PubMed
  229. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jul;2(5):449-456 - PubMed
  230. J Neuroimaging. 2019 Jan;29(1):97-103 - PubMed
  231. J Neurosci. 2005 Jun 22;25(25):6016-24 - PubMed
  232. Mol Genet Metab. 2011 Sep-Oct;104(1-2):185-8 - PubMed
  233. Alzheimers Dement. 2018 Nov;14(11):1522-1552 - PubMed
  234. J Neurol Sci. 1977 Nov;34(2):247-65 - PubMed
  235. J Nucl Med. 2013 Aug;54(8):1270-7 - PubMed
  236. JAMA. 1999 Apr 21;281(15):1401-6 - PubMed
  237. J Psychiatr Res. 2007 Aug;41(5):455-8 - PubMed
  238. Eur J Nucl Med Mol Imaging. 2016 Jun;43(6):1151-70 - PubMed
  239. J Neural Transm (Vienna). 2006 May;113(5):659-70 - PubMed
  240. Immunotherapy. 2016 Sep;8(9):1119-34 - PubMed
  241. FASEB J. 2003 Oct;17(13):1945-7 - PubMed
  242. Front Psychiatry. 2016 Feb 16;7:16 - PubMed
  243. Eur J Neurosci. 1999 May;11(5):1765-78 - PubMed
  244. J Nucl Med. 2013 Aug;54(8):1420-7 - PubMed
  245. J Nucl Med. 2006 Oct;47(10):1697-706 - PubMed
  246. Neuroimage. 2008 Feb 1;39(3):1027-33 - PubMed
  247. Neurology. 2019 Jan 8;92(2):e136-e147 - PubMed
  248. J Nucl Med. 2013 Aug;54(8):1302-7 - PubMed
  249. CNS Neurosci Ther. 2008 Spring;14(1):47-64 - PubMed
  250. ACS Chem Neurosci. 2018 Mar 21;9(3):578-586 - PubMed
  251. Alzheimers Dement. 2008 Jan;4(1 Suppl 1):S67-76 - PubMed
  252. Lancet. 1988 Oct 15;2(8616):863-6 - PubMed
  253. J Nucl Med. 2003 May;44(5):663-70 - PubMed
  254. Nucl Med Biol. 2018 Apr;59:1-8 - PubMed
  255. Nucl Med Commun. 2006 Apr;27(4):381-6 - PubMed
  256. Ann Neurol. 2016 Jan;79(1):110-9 - PubMed
  257. Neurology. 2003 Feb 25;60(4):601-5 - PubMed
  258. Brain Res Brain Res Rev. 2002 Jun;39(1):55-73 - PubMed
  259. Psychopharmacology (Berl). 2017 Feb;234(4):707-716 - PubMed
  260. Epilepsy Behav. 2009 May;15(1):50-5 - PubMed
  261. Science. 1999 Jun 11;284(5421):1845-8 - PubMed
  262. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):229-37 - PubMed
  263. Nucl Med Biol. 1993 May;20(4):503-25 - PubMed
  264. Eur J Nucl Med. 1997 Apr;24(4):372-80 - PubMed
  265. J Nucl Med. 2005 Jul;46(7):1128-35 - PubMed
  266. Pharmaceuticals (Basel). 2018 Aug 29;11(3):null - PubMed
  267. J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):129-41 - PubMed
  268. J Nucl Med. 2014 Mar;55(3):423-30 - PubMed
  269. Cerebellum Ataxias. 2018 Feb 12;5:3 - PubMed
  270. Neuroimage. 2019 Jan 1;184:826-833 - PubMed
  271. Parkinsonism Relat Disord. 2012 Jun;18(5):494-500 - PubMed
  272. Nucl Med Biol. 2010 Oct;37(7):845-51 - PubMed
  273. Eur J Nucl Med. 2000 Jun;27(6):707-12 - PubMed
  274. Am J Psychiatry. 2011 Jul;168(7):727-34 - PubMed
  275. Mol Psychiatry. 2017 Nov;22(11):1531-1538 - PubMed
  276. Nucl Med Biol. 2002 Feb;29(2):227-31 - PubMed
  277. J Nucl Med. 2016 Oct;57(10):1599-1606 - PubMed
  278. J Cereb Blood Flow Metab. 2002 Jul;22(7):878-89 - PubMed
  279. Arch Neurol. 2007 Mar;64(3):431-4 - PubMed
  280. Lancet Neurol. 2010 Jan;9(1):119-28 - PubMed
  281. Psychopharmacology (Berl). 1997 Sep;133(1):99-101 - PubMed
  282. J Nucl Med. 2019 Jan;60(1):107-114 - PubMed
  283. Addict Biol. 2019 Jul;24(4):696-706 - PubMed
  284. J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):431-6 - PubMed
  285. Biol Psychiatry. 2009 Oct 1;66(7):627-35 - PubMed
  286. Acta Neuropathol. 2005 Sep;110(3):255-60 - PubMed
  287. Nucl Med Biol. 1997 Feb;24(2):145-50 - PubMed
  288. Mov Disord. 2004 Dec;19(12):1438-45 - PubMed
  289. Eur J Nucl Med Mol Imaging. 2004 Aug;31(8):1119-27 - PubMed
  290. J Neurol Neurosurg Psychiatry. 1997 Feb;62(2):133-40 - PubMed
  291. Biol Psychiatry. 2014 Jan 15;75(2):165-71 - PubMed
  292. Am J Psychiatry. 1999 Dec;156(12):1871-8 - PubMed
  293. Biol Psychiatry. 2005 Jul 1;58(1):41-6 - PubMed
  294. J Neurol Neurosurg Psychiatry. 1994 Jul;57(7):797-804 - PubMed
  295. Nucl Med Biol. 1999 Feb;26(2):175-82 - PubMed
  296. Eur J Nucl Med Mol Imaging. 2013 Jun;40(6):921-31 - PubMed
  297. Biol Psychiatry. 2005 Jun 15;57(12):1510-6 - PubMed
  298. J Med Chem. 2016 May 26;59(10):4778-89 - PubMed
  299. J Alzheimers Dis. 2012;29(2):319-27 - PubMed
  300. Curr Opin Neurol. 2017 Dec;30(6):608-616 - PubMed
  301. Lancet Neurol. 2017 Feb;16(2):123-134 - PubMed
  302. Neurology. 2003 Mar 11;60(5):749-56 - PubMed
  303. Pharmacol Rev. 1995 Jun;47(2):181-234 - PubMed
  304. Sci Transl Med. 2016 May 11;8(338):338ra66 - PubMed
  305. J Nucl Med. 2014 Jul;55(7):1112-8 - PubMed
  306. Nucl Med Mol Imaging. 2017 Dec;51(4):283-296 - PubMed
  307. Eur J Nucl Med Mol Imaging. 2005 Nov;32(11):1329-36 - PubMed
  308. J Nucl Med. 2016 Sep;57(9):1442-7 - PubMed
  309. Med Res Rev. 2013 Jan;33(1):54-111 - PubMed
  310. Br J Psychiatry. 2015 Feb;206(2):145-52 - PubMed
  311. Int J Neuropsychopharmacol. 2018 Jul 1;21(7):656-667 - PubMed
  312. Nat Rev Neurosci. 2007 Jun;8(6):413-26 - PubMed
  313. Brain. 2010 Jun;133(Pt 6):1772-8 - PubMed
  314. Neurology. 2003 Jul 8;61(1):35-9 - PubMed
  315. J Alzheimers Dis. 2014;38(1):171-84 - PubMed
  316. Alcohol Clin Exp Res. 2007 Jan;31(1):28-32 - PubMed
  317. Psychopharmacol Ser. 1989;7:123-30 - PubMed
  318. J Biomed Biotechnol. 2012;2012:259349 - PubMed
  319. Am J Nucl Med Mol Imaging. 2014 Apr 25;4(3):260-9 - PubMed
  320. Cephalalgia. 2011 Jan;31(1):84-94 - PubMed
  321. Neurobiol Dis. 2012 Apr;46(1):130-6 - PubMed
  322. Am J Psychiatry. 2005 Feb;162(2):383-5 - PubMed
  323. Mol Psychiatry. 2015 Dec;20(12):1579-87 - PubMed
  324. J Alzheimers Dis. 2010;21(3):995-1003 - PubMed
  325. J Nucl Med. 2016 Feb;57(2):208-14 - PubMed
  326. J Nucl Med. 2011 Aug;52(8):1313-21 - PubMed
  327. Alcohol Clin Exp Res. 2006 Jul;30(7):1234-47 - PubMed
  328. J Nucl Med. 2016 Feb;57(2):165-8 - PubMed
  329. J Neurol Sci. 1999 Feb 1;163(1):94-8 - PubMed
  330. Nucl Med Biol. 2002 Jul;29(5):509-15 - PubMed
  331. Drugs Today (Barc). 2014 Mar;50(3):219-29 - PubMed
  332. J Neurosci. 2007 Sep 26;27(39):10365-71 - PubMed
  333. J Neurosci. 2005 Nov 23;25(47):10857-62 - PubMed
  334. Appl Radiat Isot. 2012 Oct;70(10):2298-307 - PubMed
  335. J Neural Transm Suppl. 1994;42:111-8 - PubMed
  336. Alzheimers Dement (Amst). 2015 Mar 29;1(1):5-13 - PubMed
  337. Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1696-703 - PubMed
  338. Eur J Nucl Med Mol Imaging. 2009 Jun;36(6):958-65 - PubMed
  339. J Nucl Med. 2016 Nov;57(11):1753-1759 - PubMed
  340. J Cereb Blood Flow Metab. 1994 May;14(3):453-65 - PubMed
  341. Synapse. 2007 Jan;61(1):17-23 - PubMed
  342. ScientificWorldJournal. 2015;2015:716514 - PubMed
  343. JAMA Neurol. 2014 Jun;71(6):758-66 - PubMed
  344. Eur J Med Chem. 2011 Jun;46(6):2295-309 - PubMed
  345. Ann Neurol. 1998 Sep;44(3 Suppl 1):S167-74 - PubMed
  346. Curr Neurol Neurosci Rep. 2018 Apr 3;18(5):22 - PubMed
  347. Eur J Nucl Med Mol Imaging. 2014 May;41(5):816-26 - PubMed
  348. Neurology. 1999 Mar 10;52(4):691-9 - PubMed
  349. Neurology. 2016 Jan 5;86(1):36-43 - PubMed
  350. J Nucl Med. 2018 Aug;59(8):1267-1274 - PubMed
  351. J Alzheimers Dis. 2012;31(3):601-12 - PubMed
  352. J Neurol. 2007 Jul;254(7):907-13 - PubMed
  353. Radiol Oncol. 2016 Jul 19;50(3):247-53 - PubMed
  354. Biol Psychiatry. 2007 Dec 1;62(11):1258-64 - PubMed
  355. Sleep. 2016 Feb 01;39(2):405-12 - PubMed
  356. Biol Psychiatry. 2007 May 1;61(9):1090-9 - PubMed
  357. J Cereb Blood Flow Metab. 2013 Apr;33(4):532-41 - PubMed
  358. Ann Neurol. 2004 Jun;55(6):774-80 - PubMed
  359. Arch Neurol. 2012 Oct;69(10):1326-31 - PubMed
  360. Transl Psychiatry. 2018 Jan 10;8(1):17 - PubMed
  361. Curr Pharm Des. 2009;15(22):2594-602 - PubMed
  362. Eur J Neurol. 2016 Feb;23(2):313-9 - PubMed
  363. J Nucl Med. 2003 Jul;44(7):999-1005 - PubMed
  364. Neurology. 2010 Mar 16;74(11):885-92 - PubMed
  365. Alzheimers Dement. 2013 Jan;9(1):e-1-16 - PubMed
  366. J Pharmacol Exp Ther. 2006 Apr;317(1):147-52 - PubMed
  367. Ann Nucl Med. 2017 Feb;31(2):163-171 - PubMed
  368. Eur J Nucl Med Mol Imaging. 2015 Jun;42(7):1119-32 - PubMed
  369. Eur J Nucl Med Mol Imaging. 2016 Feb;43(2):374-385 - PubMed
  370. Neuroimage. 2017 Aug 15;157:448-463 - PubMed
  371. Lancet Neurol. 2007 Apr;6(4):305-13 - PubMed
  372. Alzheimers Dement (Amst). 2016 Dec 22;6:11-20 - PubMed
  373. Brain. 2011 Apr;134(Pt 4):1089-100 - PubMed
  374. Genes Brain Behav. 2017 Jan;16(1):149-184 - PubMed
  375. Mol Psychiatry. 2019 Mar;24(3):322-327 - PubMed
  376. Int J Rad Appl Instrum B. 1988;15(4):463-8 - PubMed
  377. J Biol Chem. 2006 Oct 6;281(40):29739-52 - PubMed
  378. Drug Discov Today. 2007 Sep;12(17-18):748-56 - PubMed
  379. Ann Neurol. 2004 Mar;55(3):306-19 - PubMed
  380. Brain. 2016 Mar;139(Pt 3):922-36 - PubMed

Publication Types