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Affinati AH, Esfandiari NH, Oral EA, et al. Bariatric Surgery in the Treatment of Type 2 Diabetes. Curr Diab Rep. 2019;19(12):156doi: 10.1007/s11892-019-1269-4.
Affinati, A. H., Esfandiari, N. H., Oral, E. A., & Kraftson, A. T. (2019). Bariatric Surgery in the Treatment of Type 2 Diabetes. Current diabetes reports, 19(12), 156. https://doi.org/10.1007/s11892-019-1269-4
Affinati, Alison H, et al. "Bariatric Surgery in the Treatment of Type 2 Diabetes." Current diabetes reports vol. 19,12 (2019): 156. doi: https://doi.org/10.1007/s11892-019-1269-4
Affinati AH, Esfandiari NH, Oral EA, Kraftson AT. Bariatric Surgery in the Treatment of Type 2 Diabetes. Curr Diab Rep. 2019 Dec 04;19(12):156. doi: 10.1007/s11892-019-1269-4. PMID: 31802258; PMCID: PMC7522929.
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Curr Diab Rep. 2019 Dec 04;19(12):156. doi: 10.1007/s11892-019-1269-4.

Bariatric Surgery in the Treatment of Type 2 Diabetes.

Current diabetes reports

Alison H Affinati, Nazanene H Esfandiari, Elif A Oral, Andrew T Kraftson

Affiliations

  1. Division of Metabolism, Endocrinology and Diabetes (MEND), Department of Internal Medicine, Michigan Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Lobby G, Suite 1500, Ann Arbor, MI, 48106-0482, USA.
  2. Division of Metabolism, Endocrinology and Diabetes (MEND), Department of Internal Medicine, Michigan Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Lobby G, Suite 1500, Ann Arbor, MI, 48106-0482, USA. [email protected].

PMID: 31802258 PMCID: PMC7522929 DOI: 10.1007/s11892-019-1269-4

Abstract

PURPOSE OF REVIEW: We seek to characterize the impact of bariatric surgery on diabetes mellitus by recalling its history, examining the clinical data, exploring the putative mechanisms of action, and anticipating its future.

RECENT FINDINGS: Results of clinical trials reveal that bariatric surgery induces remission of diabetes in 33-90% of individuals at 1-year post-treatment versus 0-39% of medically managed. Remission rates decrease over time but remain higher in surgically treated individuals. Investigations have revealed numerous actions of surgery including effects on intestinal physiology, neuronal signaling, incretin hormone secretion, bile acid metabolism, and microbiome changes. Bariatric surgery improves control of diabetes through both weight-dependent and weight-independent actions. These various mechanisms help explain the difference between individuals treated surgically vs. medically. They also explain differing effects of various bariatric surgery procedure types. Understanding how surgery affects diabetes will help optimize utilization of the therapy for both disease prevention and treatment.

Keywords: Bariatric surgery; Diabetes mellitus; Diabetes remission; Metabolic surgery; Obesity

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