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Lumen D, Näkki S, Imlimthan S, et al. Site-Specific . Pharmaceutics. 2019;11(12)doi: 10.3390/pharmaceutics11120686.
Lumen, D., Näkki, S., Imlimthan, S., Lambidis, E., Sarparanta, M., Xu, W., Lehto, V. P., & Airaksinen, A. J. (2019). Site-Specific . Pharmaceutics, 11(12), . https://doi.org/10.3390/pharmaceutics11120686
Lumen, Dave, et al. "Site-Specific ." Pharmaceutics vol. 11,12 (2019). doi: https://doi.org/10.3390/pharmaceutics11120686
Lumen D, Näkki S, Imlimthan S, Lambidis E, Sarparanta M, Xu W, Lehto VP, Airaksinen AJ. Site-Specific . Pharmaceutics. 2019 Dec 17;11(12). doi: 10.3390/pharmaceutics11120686. PMID: 31861119; PMCID: PMC6969933.
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Pharmaceutics. 2019 Dec 17;11(12). doi: 10.3390/pharmaceutics11120686.

Site-Specific .

Pharmaceutics

Dave Lumen, Simo Näkki, Surachet Imlimthan, Elisavet Lambidis, Mirkka Sarparanta, Wujun Xu, Vesa-Pekka Lehto, Anu J Airaksinen

Affiliations

  1. Department of Chemistry, Radiochemistry, University of Helsinki, FI-00014 Helsinki, Finland.
  2. Department of Applied Physics, University of Eastern Finland, FI-70221 Kuopio, Finland.
  3. A.I. Virtanen-Institute, Department of Health Sciences, University of Eastern Finland, FI-70221 Kuopio, Finland.
  4. Turku PET Centre, University of Turku, FI-20521 Turku, Finland.

PMID: 31861119 PMCID: PMC6969933 DOI: 10.3390/pharmaceutics11120686

Abstract

Polyethylene glycol (PEG) has been successfully used for improving circulation time of several nanomaterials but prolonging the circulation of porous silicon nanoparticles (PSi NPs) has remained challenging. Here, we report a site specific radiolabeling of dual-PEGylated thermally oxidized porous silicon (DPEG-TOPSi) NPs and investigation of influence of the PEGylation on blood circulation time of TOPSi NPs.

Keywords: IEDDA; SPECT; click chemistry; indium-111; porous silicon

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