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Proteome Sci. 2019 Dec 20;17:7. doi: 10.1186/s12953-019-0155-y. eCollection 2019.

Chronic kidney disease: a review of proteomic and metabolomic approaches to membranous glomerulonephritis, focal segmental glomerulosclerosis, and IgA nephropathy biomarkers.

Proteome science

Amir Taherkhani, Reyhaneh Farrokhi Yekta, Maede Mohseni, Massoud Saidijam, Afsaneh Arefi Oskouie

Affiliations

  1. 1Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  2. 2Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  3. 3Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  4. 4Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 31889913 PMCID: PMC6925425 DOI: 10.1186/s12953-019-0155-y

Abstract

Chronic Kidney Disease (CKD) is a global health problem annually affecting millions of people around the world. It is a comprehensive syndrome, and various factors may contribute to its occurrence. In this study, it was attempted to provide an accurate definition of chronic kidney disease; followed by focusing and discussing on molecular pathogenesis, novel diagnosis approaches based on biomarkers, recent effective antigens and new therapeutic procedures related to high-risk chronic kidney disease such as membranous glomerulonephritis, focal segmental glomerulosclerosis, and IgA nephropathy, which may lead to end-stage renal diseases. Additionally, a considerable number of metabolites and proteins that have previously been discovered and recommended as potential biomarkers of various CKD

© The Author(s). 2019.

Keywords: Biomarker; Focal segmental glomerulonephritis; IgA nephropathy; Membranous glomerulonephritis; Proteomics

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

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