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Wendt R, Schliecker J, Beige J. Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series. Clin Kidney J. 2019;12(6):814-820doi: 10.1093/ckj/sfz097.
Wendt, R., Schliecker, J., & Beige, J. (2019). Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series. Clinical kidney journal, 12(6), 814-820. https://doi.org/10.1093/ckj/sfz097
Wendt, Ralph, et al. "Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series." Clinical kidney journal vol. 12,6 (2019): 814-820. doi: https://doi.org/10.1093/ckj/sfz097
Wendt R, Schliecker J, Beige J. Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series. Clin Kidney J. 2019 Aug 03;12(6):814-820. doi: 10.1093/ckj/sfz097. eCollection 2019 Dec. PMID: 31808445; PMCID: PMC6885674.
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Clin Kidney J. 2019 Aug 03;12(6):814-820. doi: 10.1093/ckj/sfz097. eCollection 2019 Dec.

Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series.

Clinical kidney journal

Ralph Wendt, Jennifer Schliecker, Joachim Beige

Affiliations

  1. Division of Nephrology and Kuratorium for Dialysis and Transplantation (KfH) Renal Unit, Hospital St Georg, Leipzig, Germany.
  2. Department of Internal Medicine II, Division of Nephrology and Rheumatology, Martin-Luther-University Halle/Wittenberg, Halle (Saale), Germany.

PMID: 31808445 PMCID: PMC6885674 DOI: 10.1093/ckj/sfz097

Abstract

BACKGROUND: Acute interstitial nephritis (AIN) is a renal injury causing renal function deterioration and requiring renal replacement therapy (RRT) in a substantial number of cases. Therapy is based on withdrawal of suspicious causative drugs or the underlying diseases and/or steroid application if renal function is not restored after cessation of the underlying condition. Hard clinical evidence for augmenting steroid therapy is not available.

METHODS: We reviewed the course and diagnosis for >20 years among all 1126 biopsied samples of our tertiary renal centre.

RESULTS: 49 (4.4%) were diagnosed with primary AIN, corresponding to an annual incidence of 1/100 000 population; 17 out of 49 biopsy-proven AIN patients required short-term or long-term (

CONCLUSIONS: Following our basic finding of the importance of histopathological parameters of acuity associated with recovery, we argue for the inauguration of grading measures to characterize this issue quantitatively and make it usable for future controlled investigations. Finally, we provide a suggestion for a therapeutic algorithm in the management of AIN.

© The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.

Keywords: C-reactive protein; cortex; dialysis; interstitial; nephritis; nephrology; scars; steroid

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