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Stürner KH, Siembab I, Schön G, et al. Is multiple sclerosis progression associated with the HLA-DR15 haplotype?. Mult Scler J Exp Transl Clin. 2019;5(4):2055217319894615doi: 10.1177/2055217319894615.
Stürner, K. H., Siembab, I., Schön, G., Stellmann, J. P., Heidari, N., Fehse, B., Heesen, C., Eiermann, T. H., Martin, R., & Binder, T. M. (2019). Is multiple sclerosis progression associated with the HLA-DR15 haplotype?. Multiple sclerosis journal - experimental, translational and clinical, 5(4), 2055217319894615. https://doi.org/10.1177/2055217319894615
Stürner, Klarissa Hanja, et al. "Is multiple sclerosis progression associated with the HLA-DR15 haplotype?." Multiple sclerosis journal - experimental, translational and clinical vol. 5,4 (2019): 2055217319894615. doi: https://doi.org/10.1177/2055217319894615
Stürner KH, Siembab I, Schön G, Stellmann JP, Heidari N, Fehse B, Heesen C, Eiermann TH, Martin R, Binder TM. Is multiple sclerosis progression associated with the HLA-DR15 haplotype?. Mult Scler J Exp Transl Clin. 2019 Dec 09;5(4):2055217319894615. doi: 10.1177/2055217319894615. eCollection 2019. PMID: 31839982; PMCID: PMC6902395.
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Mult Scler J Exp Transl Clin. 2019 Dec 09;5(4):2055217319894615. doi: 10.1177/2055217319894615. eCollection 2019.

Is multiple sclerosis progression associated with the HLA-DR15 haplotype?.

Multiple sclerosis journal - experimental, translational and clinical

Klarissa Hanja Stürner, Inessa Siembab, Gerhard Schön, Jan-Patrick Stellmann, Nika Heidari, Boris Fehse, Christoph Heesen, Thomas H Eiermann, Roland Martin, Thomas Mc Binder

Affiliations

  1. Institute for Neuroimmunology and Clinical MS Research, University Medical Center Hamburg-Eppendorf, Germany.
  2. Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Germany.
  3. Research Department Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf, Germany.
  4. HLA Laboratory, University Medical Center Hamburg-Eppendorf, Germany.

PMID: 31839982 PMCID: PMC6902395 DOI: 10.1177/2055217319894615

Abstract

BACKGROUND: The prevalence of multiple sclerosis is associated with the major histocompatibility complex class II DR15 haplotype HLA-DRB1*15:01∼HLA-DRB5*01:01.

OBJECTIVE: To assess whether multiple sclerosis progression is associated with the main susceptibility haplotype HLA-DRB1*15:01∼HLA-DRB5*01:01.

METHODS: Patients (

RESULTS: After follow-up of the consecutive cohort 349 patients were classified as having clinical isolated syndrome and 881 patients as having multiple sclerosis. The susceptibility allele HLA-DRB1*15:01 was more frequent in clinical isolated syndrome (odds ratio 1.56) and multiple sclerosis (odds ratio 3.17) compared to controls. HLA- DRB1*15:01 was the only enriched HLA-DRB1 allele in multiple sclerosis patients. Comparison of clinical characteristics between HLA-DRB1*15:01∼HLA-DRB5*01:01 negative and positive patients with multiple sclerosis showed that baseline EDSS score, disease duration and frequency of the category secondary progressive multiple sclerosis with relapse were increased in the HLA-DRB1*15:01∼HLA-DRB5*01:01 positive group.

CONCLUSION: The study confirmed HLA-DRB1*15:01 and HLA-DRB5*01:01 as the main susceptibility alleles and showed weak indirect evidence for a role in progression of the disease.

© The Author(s) 2019.

Keywords: EDSS; HLA-DRB1*15:01; HLA-DRB5*01:01; Multiple sclerosis; progression

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