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Qiu Z, Wei Y, Song Q, et al. The Role of Myocardial Mitochondrial Quality Control in Heart Failure. Front Pharmacol. 2019;10:1404doi: 10.3389/fphar.2019.01404.
Qiu, Z., Wei, Y., Song, Q., Du, B., Wang, H., Chu, Y., & Hu, Y. (2019). The Role of Myocardial Mitochondrial Quality Control in Heart Failure. Frontiers in pharmacology, 101404. https://doi.org/10.3389/fphar.2019.01404
Qiu, Zhiling, et al. "The Role of Myocardial Mitochondrial Quality Control in Heart Failure." Frontiers in pharmacology vol. 10 (2019): 1404. doi: https://doi.org/10.3389/fphar.2019.01404
Qiu Z, Wei Y, Song Q, Du B, Wang H, Chu Y, Hu Y. The Role of Myocardial Mitochondrial Quality Control in Heart Failure. Front Pharmacol. 2019 Dec 06;10:1404. doi: 10.3389/fphar.2019.01404. eCollection 2019. PMID: 31866862; PMCID: PMC6910121.
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Front Pharmacol. 2019 Dec 06;10:1404. doi: 10.3389/fphar.2019.01404. eCollection 2019.

The Role of Myocardial Mitochondrial Quality Control in Heart Failure.

Frontiers in pharmacology

Zhiling Qiu, Yi Wei, Qingqiao Song, Bai Du, Huan Wang, Yuguang Chu, Yuanhui Hu

Affiliations

  1. Department of General Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
  2. Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

PMID: 31866862 PMCID: PMC6910121 DOI: 10.3389/fphar.2019.01404

Abstract

At present, the treatment of heart failure has entered the plateau phase, and it is necessary to thoroughly study the pathogenesis of heart failure and find out the corresponding treatment methods. Myocardial mitochondria is the main site of cardiac energy metabolism, whose dysfunction is an important factor leading to cardiac dysfunction and heart failure. Mitochondria are highly dynamic organelles. Continuous biogenesis, fusion, fission and mitophagy, contribute to the balance of mitochondria's morphology, quantity, and quality, which is called mitochondrial quality control. Mitochondrial quality control is the cornerstone of normal mitochondrial function and is found to play an important role in the pathological process of heart failure. Here, we provide an overview of the mechanisms of mitochondrial quality control and recent studies on mitochondrial quality control in heart failure, hoping to provide new ideas for drug development in heart failure.

Copyright © 2019 Qiu, Wei, Song, Du, Wang, Chu and Hu.

Keywords: heart failure; mitochondrial biogenesis; mitochondrial dynamics; mitochondrial quality control; mitophagy

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