J Indian Assoc Pediatr Surg. 2020 Jan-Feb;25(1):38-42. doi: 10.4103/jiaps.JIAPS_244_18. Epub 2019 Nov 27.
Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction.
Journal of Indian Association of Pediatric Surgeons
Abhishek Gupta, Veereshwar Bhatnagar, Anjan Kumar Dhua, Manisha Jana, Archana Singh, Rohan Malik
Affiliations
Affiliations
- Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
- Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
- Department of Biochemistery, All India Institute of Medical Sciences, New Delhi, India.
- Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
PMID: 31896898
PMCID: PMC6910058 DOI: 10.4103/jiaps.JIAPS_244_18
Abstract
AIM: The aim was to study the correlation of hepatic artery resistive index (HARI) with the portal pressure (PP) and its surrogate marker serum nitric oxide (NO) levels and to determine the validity of HARI as noninvasive indirect marker of PP in extrahepatic portal venous obstruction (EHPVO) pre- and postoperatively.
METHODS: A prospective study was conducted on 19 patients with EHPVO undergoing proximal lienorenal (LR) shunt or devascularization from February 2016 to January 2018. HARI, calculated from Doppler sonography, and NO were measured preoperatively and 14, 30 and 90 days postoperatively. Intraoperatively, PP was measured before splenectomy, and both PP and NO were measured postshunt.
RESULTS: Mean age was 10.58 ± 2.85 years, and male:female ratio was 15:4. LR shunt was done in 16 while three patients required devascularization. There was a significant fall in the HARI (0.06 ± 0.02,
CONCLUSION: HARI bears no correlation with PP or NO. Hence, it cannot be used as an indirect marker of PP.
Copyright: © 2019 Journal of Indian Association of Pediatric Surgeons.
Keywords: Extrahepatic portal venous obstruction; hepatic artery resistive index; nitric oxide; portal pressure
Conflict of interest statement
There are no conflicts of interest.
References
- AJR Am J Roentgenol. 1995 Jul;165(1):167-72 - PubMed
- J Ultrasound Med. 2007 Dec;26(12):1689-96 - PubMed
- AJR Am J Roentgenol. 2001 Apr;176(4):909-12 - PubMed
- J Indian Assoc Pediatr Surg. 2016 Apr-Jun;21(2):49-53 - PubMed
- J Clin Exp Hepatol. 2013 Jun;3(2):102-5 - PubMed
- Eur Radiol. 2000;10(11):1703-7 - PubMed
- Science. 1965 Nov 19;150(3699):1030-1 - PubMed
- J Indian Assoc Pediatr Surg. 2017 Oct-Dec;22(4):237-241 - PubMed
- J Indian Assoc Pediatr Surg. 2015 Jul-Sep;20(3):133-8 - PubMed
- Gastroenterology. 1995 Apr;108(4):1152-8 - PubMed
- J Indian Assoc Pediatr Surg. 2010 Oct;15(4):117-21 - PubMed
Publication Types