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Am J Ther. 2019 Dec 03;28(6):e772-e776. doi: 10.1097/MJT.0000000000001122.

Amlodipine Repositioning: Scientific Studies and Synergistic Effects.

American journal of therapeutics

Silvana S Coelho, Taciéli F da Rosa, Roberta F Rampelotto, Marissa B Serafin, Angelita Bottega, Vitória S Foletto, Catrine S Machado, Rosmari Hörner

Affiliations

  1. Graduate Program in Pharmaceutical Sciences (PPGCF), Department of Clinical and Toxicological Analysis, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.
  2. Department of Clinical and Toxicological Analysis, UFSM, Santa Maria, Rio Grande do Sul, Brazil.

PMID: 31815753 DOI: 10.1097/MJT.0000000000001122

[No abstract available.]

Conflict of interest statement

The authors have no conflicts of interest to declare.

References

  1. Kulkarni NS, Guererro Y, Gupta N, et al. Exploring potential of quantum dots as dual modality for cancer therapy and diagnosis. J Drug Deliv Sci Technol. 2019;49:352–364. - PubMed
  2. Parvathaneni V, Kulkarni NS, Muth A, et al. Drug repurposing: a promising tool to accelerate the drug discovery process. Drug Discov Today. 2019. doi: 10.1016/j.drudis.2019.06.014. - PubMed
  3. Estrela TS. Antimicrobial Resistance: Multilateral Approach and Brazilian Response. Health and External Policy: 20 Years of the Office of International Health Affairs of the Ministry of Health of Brazil (1998-2018). Vol 1. 1st ed. Brasília, Brazil: Ministry of Health Publisher; 2018:11–364. Available at: http://bvsms.saude.gov.br/bvs/publicacoes/salud_politica_externa_20anos_espanhol.pdf. Accessed September 9, 2018. - PubMed
  4. Huang J, Zhao D, Liu Z, et al. Repurposing psychiatric drugs as anti-cancer agentes. Cancer Lett. 2018;419:257–265. - PubMed
  5. Thakare R, Singh AK, Das S, et al. Repurposing Ivacaftor for treatment of Staphylococcus aureus infections. Int J Antimicrob Agents. 2017;50:389–392. - PubMed
  6. Zheng W, Sun W, Simeonov A. Drug repurposing screens and synergistic drug-combinations for infectious diseases. Br J Pharmacol. 2018;175:181–191. - PubMed
  7. Serafin MB, Hörner R. Drug repositioning, a new alternative in infectious diseases. Braz J Infect Dis. 2018;22:252–256. - PubMed
  8. Petrova E. Innovation in the pharmaceutical industry: the process of drug discovery and development. In: Ding M, Eliashberg J, Stremersch S; SpringerLink (Online service), eds. Innovation and Marketing in the Pharmaceutical Industry Emerging Practices, Research, and Policies New York, NY: Springer; 2014:1122–1149. - PubMed
  9. Zilberberg MD, Shorr AF, Micek ST, et al. Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study. Crit Care. 2014;18:596. - PubMed
  10. Aldeyab MA, Monnet DL, Lopez-Lozano JM, et al. Modelling the impact of antibiotic use and infection control practices on the incidence of hospital-acquired methicillin-resistant Staphylococcus aureus: a time-series analysis. J Antimicrob Chemother. 2008;62:593–600. - PubMed
  11. Qin X, Tran BG, Kim MJ, et al. A randomised, double-blind, phase 3 study comparing the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem for complicated intra-abdominal infections in hospitalised adults in Asia. Int J Antimicrob Agents. 2017. doi: 10.1016/j.ijantimicag.2017.01.010. - PubMed
  12. Chan EWL, Yee ZY, Raja I, et al. Synergistic effect of non-steroidal anti-inflammatory drugs (NSAIDs) on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus. J Glob Antimicrob Re. 2017;10:70–74. - PubMed
  13. Palit P, Ali N. Oral therapy with amlodipine and lacidipine, 1,4-dihydropyridine derivatives showing activity against experimental visceral leishmaniasis. Antimicrob Agents Chemother. 2008;52:374–377. - PubMed
  14. Rampelotto RF, Lorenzoni VV, Silva DDC, et al. Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl)-3-phenyltriazene N3-oxide-κ2 N1, O4] (dimethylbenzylamine-κ2 C1, N4)palladium(II)}. Braz J Pharm. 2018;54:e17369. - PubMed
  15. Godfraind T. Calcium channel blockers in cardiovascular pharmacotherapy. J Cardiovasc Pharmacol Ther. 2014;19:501–515. - PubMed
  16. Spader TB, Castrillón MR, Valente P, et al. In vitro interactions of amphotericin B combined with non-antifungal agents against Rhodotorula mucilaginosa strains. Mycopathologia. 2019. doi: 10.1007/s11046-019-0317-6. - PubMed
  17. Liu S, Yue L, Gu W, et al. Synergistic effect of fluconazole and calcium channel blockers against resistant Candida albicans. PLoS One. 2016;11:e0150859. - PubMed
  18. Pereira MR, Henrich PP, Sidhu ABSS, et al. In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine. Antimicrob Agents Chemother. 2011;55:3115–3124. - PubMed
  19. Verma A, Bhandaria V, Deep DK, et al. Transcriptome profiling identifies genes/pathways associated with experimental resistance to paromomycin in Leishmania donovani. Int J Parasitol Drugs Drug Resist. 2017;7:370–377. - PubMed
  20. Reimão JQ, Scotti MT, Tempone AG. Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure–activity relationship study. Bioorgan Med Chem. 2010;18:8044–8053. - PubMed
  21. Li YJ, Pan CZ, Zhao ZW, et al. Effects of a combination of amlodipine and imipenem on 42 clinical isolates of Acinetobacter baumannii obtained from a teaching hospital in Guangzhou, China. BMC Infect Dis. 2013;13:548. - PubMed
  22. Hu C, Li Y, Zhao Z, et al. In vitro synergistic effect of amlodipine and imipenem on the expression of the AdeABC efflux pump in multidrug-resistant Acinetobacter baumannii. PLoS One. 2018;13:e0198061. - PubMed
  23. Mazumdar K, Kumar KA, Dutta NK. Potential role of the cardiovascular non-antibiotic (helper compound) amlodipine in the treatment of microbial infections: scope and hope for the future. Int J Antimicrob. 2010;36:295–302. - PubMed
  24. Kumar KA, Ganguly K, Mazumdar K, et al. Amlodipine: a cardiovascular drug with powerful antimicrobial property. Acta Microbiol Pol. 2003;52:285–292. - PubMed
  25. Elkhatib WF, Haynes VL, Noreddin AM. Microbiological appraisal of levofloxacin activity against Pseudomonas aeruginosa biofilm in combination with different calcium chanel blockers in vitro. J Chemother. 2009;21:135–143. - PubMed
  26. Li X, Lu WL, Liang GW, et al. Effect of stealthy liposomal topotecan plus amlodipine on the multidrug-resistant leukaemia cells in vitro and xenograft in mice. Eur J Clin Invest. 2006;36:409–418. - PubMed
  27. Zhang Y, Li RJ, Ying X, et al. Targeting therapy with mitosomal daunorubicin plus amlodipine has the potential to circumvent intrinsic resistant breast cancer. Mol Pharm. 2010;8:162–175. - PubMed
  28. Yoshida J, Ishibashi T, Nishio M. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004;492:103–112. - PubMed
  29. Yoshida J, Ishibashi T, Nishio M. G1 cell cycle arrest by amlodipine, a dihydropyridine Ca2+ channel blocker, in human epidermoid carcinoma A431 cells. Biochem Pharmacol. 2007;73:943–953. - PubMed
  30. Lan L, Xinghua X, Wenjuan S, et al. Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells. J Med Colleges PLA. 2008;23:358–363. - PubMed

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