Display options
Cite
Meltzer S, Bakke KM, Rød KL, et al. Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?. Clin Transl Radiat Oncol. 2019;21:5-10doi: 10.1016/j.ctro.2019.11.006.
Meltzer, S., Bakke, K. M., Rød, K. L., Negård, A., Flatmark, K., Solbakken, A. M., Kristensen, A. T., Fuglestad, A. J., Kersten, C., Dueland, S., Seierstad, T., Hole, K. H., Lyckander, L. G., Larsen, F. O., Schou, J. V., Patrick Brown, D., Abrahamsson, H., Redalen, K. R., & Ree, A. H. (2020). Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?. Clinical and translational radiation oncology, 215-10. https://doi.org/10.1016/j.ctro.2019.11.006
Meltzer, Sebastian, et al. "Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?." Clinical and translational radiation oncology vol. 21 (2020): 5-10. doi: https://doi.org/10.1016/j.ctro.2019.11.006
Meltzer S, Bakke KM, Rød KL, Negård A, Flatmark K, Solbakken AM, Kristensen AT, Fuglestad AJ, Kersten C, Dueland S, Seierstad T, Hole KH, Lyckander LG, Larsen FO, Schou JV, Patrick Brown D, Abrahamsson H, Redalen KR, Ree AH. Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?. Clin Transl Radiat Oncol. 2019 Dec 02;21:5-10. doi: 10.1016/j.ctro.2019.11.006. eCollection 2020 Mar. PMID: 31872084; PMCID: PMC6909215.
Copy Download .nbib Format: NLM
Share it on

Clin Transl Radiat Oncol. 2019 Dec 02;21:5-10. doi: 10.1016/j.ctro.2019.11.006. eCollection 2020 Mar.

Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?.

Clinical and translational radiation oncology

Sebastian Meltzer, Kine Mari Bakke, Karina Lund Rød, Anne Negård, Kjersti Flatmark, Arne Mide Solbakken, Annette Torgunrud Kristensen, Anniken Jørlo Fuglestad, Christian Kersten, Svein Dueland, Therese Seierstad, Knut Håkon Hole, Lars Gustav Lyckander, Finn Ole Larsen, Jakob Vasehus Schou, Dawn Patrick Brown, Hanna Abrahamsson, Kathrine Røe Redalen, Anne Hansen Ree

Affiliations

  1. Department of Oncology, Akershus University Hospital, Lørenskog, Norway.
  2. Department of Physics, University of Oslo, Oslo, Norway.
  3. Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway.
  4. Department of Medical Physics, Oslo University Hospital Norwegian Radium Hospital, Oslo, Norway.
  5. Department of Radiology, Akershus University Hospital, Lørenskog, Norway.
  6. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  7. Department of Tumor Biology, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway.
  8. Department of Gastroenterological Surgery, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway.
  9. Center for Cancer Treatment, Sørlandet Hospital, Kristiansand, Norway.
  10. Department of Oncology, Oslo University Hospital - Norwegian Radium Hospital, Oslo, Norway.
  11. Department of Research and Development, Division for Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
  12. Department of Radiology, Oslo University Hospital, Oslo, Norway.
  13. Department of Pathology, Akershus University Hospital, Lørenskog, Norway.
  14. Department of Oncology, Herlev and Gentofte Hospital, Herlev, Denmark.

PMID: 31872084 PMCID: PMC6909215 DOI: 10.1016/j.ctro.2019.11.006

Abstract

BACKGROUND AND PURPOSE: We investigated how features relating to pelvic cavity anatomy and tumor hemodynamic factors may influence systemic failure in rectal cancer.

MATERIALS AND METHODS: Rectal cancer patients (207 women, 343 men), who had been prospectively enrolled onto six cohorts and given curative-intent therapy, were analyzed for the first metastatic event. In one of the cohorts, the diameter of the inferior mesenteric vein (IMV) was assessed on diagnostic abdominal computed tomography images (n = 113). Tumor volume (n = 193) and histologic response to neoadjuvant therapy (n = 445) were recorded from diagnostic magnetic resonance images and surgical specimens, respectively.

RESULTS: More women than men developed lung metastasis (p = 0.037), while the opposite was the case for liver metastasis (p = 0.040). Wider IMV diameter correlated with larger tumor volume (r = 0.481, p < 0.001) and male sex (p < 0.001). Female sex was the only adverse prognostic factor for lung metastasis. When sex, tumor volume, and histologic response were taken into consideration, poor tumor response remained the only determinant for liver metastasis (p = 0.002).

CONCLUSIONS: In a diverse rectal cancer population given curative-intent treatment, women and men had different outcome with regard to the primary metastatic site. Tumor hemodynamic factors should be considered in rectal cancer risk stratification.

© 2019 The Author(s).

Keywords: Metastasis; Radiology; Radiotherapy; Rectal cancer; Sex

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

  1. JAMA Oncol. 2018 Jul 12;4(7):e173695 - PubMed
  2. Nat Med. 2015 Nov;21(11):1350-6 - PubMed
  3. Acta Oncol. 2017 Jun;56(6):813-818 - PubMed
  4. Sci Rep. 2016 Jul 15;6:29765 - PubMed
  5. Cancer Epidemiol. 2018 Apr;53:56-64 - PubMed
  6. JAMA Oncol. 2017 Feb 1;3(2):194-201 - PubMed
  7. AJR Am J Roentgenol. 2013 Nov;201(5):985-92 - PubMed
  8. Lancet Oncol. 2014 Feb;15(2):184-90 - PubMed
  9. JAMA Oncol. 2017 Oct 1;3(10):1386-1392 - PubMed
  10. J Am Coll Surg. 2015 Aug;221(2):430-40 - PubMed
  11. J Clin Oncol. 2019 Dec 1;37(34):3212-3222 - PubMed
  12. Surg Oncol. 2006 Dec;15(4):243-55 - PubMed
  13. Lancet Oncol. 2015 Aug;16(8):979-89 - PubMed
  14. Lancet Oncol. 2010 Sep;11(9):835-44 - PubMed
  15. JAMA Surg. 2018 Jan 1;153(1):60-67 - PubMed
  16. Histopathology. 2009 May;54(6):713-21 - PubMed
  17. HPB (Oxford). 2016 Mar;18(3):209-20 - PubMed
  18. Front Oncol. 2015 Dec 22;5:286 - PubMed
  19. Nat Rev Clin Oncol. 2011 Aug 09;8(11):649-59 - PubMed
  20. Radiother Oncol. 2013 Jul;108(1):48-54 - PubMed
  21. Clin Cancer Res. 2018 Mar 1;24(5):1062-1072 - PubMed
  22. JAMA Oncol. 2017 Feb 1;3(2):211-219 - PubMed
  23. J Thorac Dis. 2016 Jun;8(6):1155-61 - PubMed
  24. Colorectal Dis. 2017 Dec;19(12):1076-1080 - PubMed
  25. Cancer. 2002 Feb 15;94(4):1121-30 - PubMed
  26. Br J Radiol. 2015 Jul;88(1051):20150097 - PubMed
  27. Int J Colorectal Dis. 2014 Mar;29(3):301-7 - PubMed
  28. Cancer. 1994 Jun 1;73(11):2680-6 - PubMed
  29. Oncotarget. 2016 May 31;7(22):33374-80 - PubMed

Publication Types