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Maier R, Akbari A, Wei X, et al. No statistical evidence for an effect of CCR5-∆32 on lifespan in the UK Biobank cohort. Nat Med. 2019;26(2):178-180doi: 10.1038/s41591-019-0710-1.
Maier, R., Akbari, A., Wei, X., Patterson, N., Nielsen, R., & Reich, D. (2020). No statistical evidence for an effect of CCR5-∆32 on lifespan in the UK Biobank cohort. Nature medicine, 26(2), 178-180. https://doi.org/10.1038/s41591-019-0710-1
Maier, Robert, et al. "No statistical evidence for an effect of CCR5-∆32 on lifespan in the UK Biobank cohort." Nature medicine vol. 26,2 (2020): 178-180. doi: https://doi.org/10.1038/s41591-019-0710-1
Maier R, Akbari A, Wei X, Patterson N, Nielsen R, Reich D. No statistical evidence for an effect of CCR5-∆32 on lifespan in the UK Biobank cohort. Nat Med. 2020 Feb;26(2):178-180. doi: 10.1038/s41591-019-0710-1. Epub 2019 Dec 23. PMID: 31873311; PMCID: PMC7302696.
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Nat Med. 2020 Feb;26(2):178-180. doi: 10.1038/s41591-019-0710-1. Epub 2019 Dec 23.

No statistical evidence for an effect of CCR5-∆32 on lifespan in the UK Biobank cohort.

Nature medicine

Robert Maier, Ali Akbari, Xinzhu Wei, Nick Patterson, Rasmus Nielsen, David Reich

Affiliations

  1. Department of Genetics, Harvard Medical School, Boston, MA, USA. [email protected].
  2. Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected].
  3. Department of Genetics, Harvard Medical School, Boston, MA, USA. [email protected].
  4. Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected].
  5. Department of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA, USA.
  6. Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  7. Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
  8. GeoGenetics Centre, University of Copenhagen, Copenhagen, Denmark.
  9. Department of Genetics, Harvard Medical School, Boston, MA, USA.
  10. Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

PMID: 31873311 PMCID: PMC7302696 DOI: 10.1038/s41591-019-0710-1

[No abstract available.]

References

  1. Samson, M. et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382, 722–725 (1996). - PubMed
  2. Hütter, G. et al. Long-term control of HIV by CCR5 delta32/delta32 stem-cell transplantation. N. Engl. J. Med. 360, 692–698 (2009). - PubMed
  3. Gupta, R. K. et al. HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation. Nature 568, 244–248 (2019). - PubMed
  4. Wei, X. & Nielsen, R. Retraction note: CCR5-∆32 is deleterious in the homozygous state in humans. Nat. Med. 25, 1796 (2019). - PubMed
  5. Wei, X. & Nielsen, R. Deviations from Hardy Weinberg equilibrium at CCR5-Δ32 in large sequencing data sets. Preprint at bioRxiv https://www.biorxiv.org/content/10.1101/768390v2 (2019). - PubMed
  6. Harrison, S. “CCR5-∆32 is deleterious in the homozygous state in humans”—is it? Sean Harrison: Blog https://seanharrisonblog.com/2019/06/20/ccr5-%e2%88%8632-is-deleterious-in-the-homozygous-state-in-humans-is-it/ (2019). - PubMed
  7. Gudbjartsson, D. et al. CCR5-del32 is not deleterious in the homozygous state in humans. Preprint at bioRxiv https://doi.org/10.1101/788117 (2019). - PubMed
  8. Karczewski, K. J., Gauthier, L. D. & Daly, M. J. Technical artifact drives apparent deviation from Hardy–Weinberg equilibrium at CCR5-∆32 and other variants in gnomAD. Preprint at bioRxiv https://doi.org/10.1101/784157 (2019). - PubMed
  9. Tanigawa, Y. & Rivas, M. A. Reported CCR5-∆32 deviation from Hardy-Weinberg equilibrium is explained by poor genotyping of rs62625034. Preprint at bioRxiv https://doi.org/10.1101/791517 (2019). - PubMed

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