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J Ophthalmic Inflamm Infect. 2019 Dec 23;9(1):21. doi: 10.1186/s12348-019-0190-y.

Optical coherence tomography angiography in uveitis.

Journal of ophthalmic inflammation and infection

Paris Tranos, Evdoxia-Maria Karasavvidou, Olga Gkorou, Carlos Pavesio

Affiliations

  1. Vitreoretinal & Uveitis Department, Ophthalmica Clinic, Vas.Olgas 196 and Ploutonos, 546 55, Thessaloniki, Greece.
  2. Vitreoretinal & Uveitis Department, Ophthalmica Clinic, Vas.Olgas 196 and Ploutonos, 546 55, Thessaloniki, Greece. [email protected].
  3. Department of Ophthalmology, Hippokrateio General Hospital of Thessaloniki, 49 Konstantinoupoleos Street, 546 42, Thessaloniki, Greece. [email protected].
  4. Uveitis Department, Moorfields Eye Hospital, 162 City Rd, London, EC1V 2PD, UK.

PMID: 31873858 PMCID: PMC6928173 DOI: 10.1186/s12348-019-0190-y

Abstract

Before the introduction of optical coherence tomography angiography (OCTA) in the early 2000s, dye-based angiography was considered the "gold standard" for the diagnosis and monitoring of ocular inflammation. OCTA is a novel technique, which demonstrates capillary networks based on the amount of light returned from moving blood cells, providing further information on pathophysiological changes in uveitis.The aim of this review is to describe the basic principles of OCTA and its application to ocular inflammatory disorders. It particularly emphasizes on its contribution not only in the diagnosis and management of the disease but also in the identification of possible complications, comparing it with fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA). Although the advent of OCTA has remarkably enhanced the assessment of uveitic entities, we highlight the need for further investigation in order to better understand its application to these conditions.

Keywords: Blood flow; Chorioretinal inflammation; Dye-based angiography; Optical coherence tomography angiography; Uveitis

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