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Lempiäinen J, Ijäs P, Niiranen TJ, et al. Haptoglobin Hp1 Variant Does Not Associate with Small Vessel Disease. Brain Sci. 2019;10(1)doi: 10.3390/brainsci10010018.
Lempiäinen, J., Ijäs, P., Niiranen, T. J., Kaste, M., Karhunen, P. J., Lindsberg, P. J., Erkinjuntti, T., & Melkas, S. (2019). Haptoglobin Hp1 Variant Does Not Associate with Small Vessel Disease. Brain sciences, 10(1), . https://doi.org/10.3390/brainsci10010018
Lempiäinen, Juha, et al. "Haptoglobin Hp1 Variant Does Not Associate with Small Vessel Disease." Brain sciences vol. 10,1 (2019). doi: https://doi.org/10.3390/brainsci10010018
Lempiäinen J, Ijäs P, Niiranen TJ, Kaste M, Karhunen PJ, Lindsberg PJ, Erkinjuntti T, Melkas S. Haptoglobin Hp1 Variant Does Not Associate with Small Vessel Disease. Brain Sci. 2019 Dec 28;10(1). doi: 10.3390/brainsci10010018. PMID: 31905636; PMCID: PMC7016682.
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Brain Sci. 2019 Dec 28;10(1). doi: 10.3390/brainsci10010018.

Haptoglobin Hp1 Variant Does Not Associate with Small Vessel Disease.

Brain sciences

Juha Lempiäinen, Petra Ijäs, Teemu J Niiranen, Markku Kaste, Pekka J Karhunen, Perttu J Lindsberg, Timo Erkinjuntti, Susanna Melkas

Affiliations

  1. Clinical Neurosciences, University of Helsinki, 00014 Helsinki, Finland.
  2. Department of Neurology, Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.
  3. Department of Public Health Solutions, National institute for Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland.
  4. Division of Medicine, Turku University Hospital and University of Turku, 20014 Turku, Finland.
  5. School of Medicine, University of Tampere, 33014 Tampere, Finland.
  6. FimLab Laboratories Ltd., Tampere University Hospital Region, 33014 Tampere, Finland.

PMID: 31905636 PMCID: PMC7016682 DOI: 10.3390/brainsci10010018

Abstract

Haptoglobin (Hp) is a plasma protein that binds free hemoglobin and protects tissues from oxidative damage. An Hp2 allele has been associated with an increased risk of cardiovascular complications. On the other hand, recent studies have suggested that Hp1 allele increases risk to develop severe cerebral small vessel disease. We aimed to replicate this finding in a first-ever stroke patient cohort. Hp was genotyped by PCR and gel electrophoresis in the Helsinki Stroke Aging Memory Study in patients with DNA and magnetic resonance imaging (MRI) available (SAM;

Keywords: haptoglobins; lacunar infarct; small vessel disease (SVD); white matter lesions (WML)

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