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Matías J, Brotons A, Cenoz S, et al. Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer-Membrane Vesicles Incorporated into Zein-Based Nanoparticles. Vaccines (Basel). 2019;8(1)doi: 10.3390/vaccines8010011.
Matías, J., Brotons, A., Cenoz, S., Pérez, I., Abdulkarim, M., Gumbleton, M., Irache, J. M., & Gamazo, C. (2019). Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer-Membrane Vesicles Incorporated into Zein-Based Nanoparticles. Vaccines, 8(1), . https://doi.org/10.3390/vaccines8010011
Matías, Jose, et al. "Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer-Membrane Vesicles Incorporated into Zein-Based Nanoparticles." Vaccines vol. 8,1 (2019). doi: https://doi.org/10.3390/vaccines8010011
Matías J, Brotons A, Cenoz S, Pérez I, Abdulkarim M, Gumbleton M, Irache JM, Gamazo C. Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer-Membrane Vesicles Incorporated into Zein-Based Nanoparticles. Vaccines (Basel). 2019 Dec 31;8(1). doi: 10.3390/vaccines8010011. PMID: 31906120; PMCID: PMC7157560.
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Vaccines (Basel). 2019 Dec 31;8(1). doi: 10.3390/vaccines8010011.

Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer-Membrane Vesicles Incorporated into Zein-Based Nanoparticles.

Vaccines

Jose Matías, Ana Brotons, Santiago Cenoz, Isidoro Pérez, Muthanna Abdulkarim, Mark Gumbleton, Juan M Irache, Carlos Gamazo

Affiliations

  1. Department of Microbiology and Parasitology, Institute of Tropical Health, University of Navarra, 31008 Pamplona, Spain.
  2. Department of Pharmacy and Pharmaceutical Technology, University of Navarra, 31008 Pamplona, Spain.
  3. Blue Agro Bioscience, Parque Tecnológico Miramón. Paseo Mikeletegi, 54. 20009 San Sebastián, Spain.
  4. Agropecuario Obanos, Marcilla, 31340 Navarra, Spain.
  5. School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NB, UK.

PMID: 31906120 PMCID: PMC7157560 DOI: 10.3390/vaccines8010011

Abstract

Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of illness and death in neonatal and recently weaned pigs. The immune protection of the piglets derives from maternal colostrum, since this species does not receive maternal antibodies through the placenta. In the present study, outer membrane vesicles (OMVs) obtained from main ETEC strains involved in piglet infection (F4 and F18 serotypes), encapsulated into zein nanoparticles coated with Gantrez

Keywords: ETEC; Escherichia coli; nanoparticles; outer membrane vesicles; vaccine

Conflict of interest statement

Authors declare no conflicts of interest

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