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Blasco V, Pinto FM, González-Ravina C, et al. Tachykinins and Kisspeptins in the Regulation of Human Male Fertility. J Clin Med. 2019;9(1)doi: 10.3390/jcm9010113.
Blasco, V., Pinto, F. M., González-Ravina, C., Santamaría-López, E., Candenas, L., & Fernández-Sánchez, M. (2019). Tachykinins and Kisspeptins in the Regulation of Human Male Fertility. Journal of clinical medicine, 9(1), . https://doi.org/10.3390/jcm9010113
Blasco, Víctor, et al. "Tachykinins and Kisspeptins in the Regulation of Human Male Fertility." Journal of clinical medicine vol. 9,1 (2019). doi: https://doi.org/10.3390/jcm9010113
Blasco V, Pinto FM, González-Ravina C, Santamaría-López E, Candenas L, Fernández-Sánchez M. Tachykinins and Kisspeptins in the Regulation of Human Male Fertility. J Clin Med. 2019 Dec 31;9(1). doi: 10.3390/jcm9010113. PMID: 31906206; PMCID: PMC7019842.
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J Clin Med. 2019 Dec 31;9(1). doi: 10.3390/jcm9010113.

Tachykinins and Kisspeptins in the Regulation of Human Male Fertility.

Journal of clinical medicine

Víctor Blasco, Francisco M Pinto, Cristina González-Ravina, Esther Santamaría-López, Luz Candenas, Manuel Fernández-Sánchez

Affiliations

  1. IVI-RMA Seville, Avda. República Argentina 58, ES-41011 Seville, Spain.
  2. IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), ES-46026 Valencia, Spain.
  3. Instituto de Investigaciones Químicas, CSIC, Avenida Americo Vespucio 49, ES-41092 Seville, Spain.
  4. Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, ES-41013 Seville, Spain.
  5. Departamento de Cirugía, Universidad de Sevilla, Avda. Sánchez Pizjuan S/N, ES-41009 Seville, Spain.

PMID: 31906206 PMCID: PMC7019842 DOI: 10.3390/jcm9010113

Abstract

Infertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role in this function: tachykinins and kisspeptins. With this aim, we conducted an exhaustive review in order to describe the role of tachykinins and kisspeptins in human fertility and their possible implications in infertility etiopathogenesis. Many advances have been made to elucidate the roles of these two families in infertility, and multiple animal species have been studied, including humans. All of this knowledge could lead to new advances in male infertility diagnosis and treatment, but further research is needed to clarify all the implications of tachykinins and kisspeptins in fertility.

Keywords: assisted reproductive technology; kisspeptin; male infertility; neurokinin; tachykinin

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