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Zhang R, Wu J, Liu S, et al. Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS. Pharmaceutics. 2020;12(1)doi: 10.3390/pharmaceutics12010035.
Zhang, R., Wu, J., Liu, S., Deng, L., Hu, J., Chen, X., & Tan, W. (2020). Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS. Pharmaceutics, 12(1), . https://doi.org/10.3390/pharmaceutics12010035
Zhang, Rui, et al. "Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS." Pharmaceutics vol. 12,1 (2020). doi: https://doi.org/10.3390/pharmaceutics12010035
Zhang R, Wu J, Liu S, Deng L, Hu J, Chen X, Tan W. Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS. Pharmaceutics. 2020 Jan 02;12(1). doi: 10.3390/pharmaceutics12010035. PMID: 31906459; PMCID: PMC7023290.
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Pharmaceutics. 2020 Jan 02;12(1). doi: 10.3390/pharmaceutics12010035.

Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS.

Pharmaceutics

Rui Zhang, Jie Wu, Siyu Liu, LiangJun Deng, Junhua Hu, Xi Chen, Wen Tan

Affiliations

  1. Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, Guangdong, China.
  2. School of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China.
  3. YZ Health-tech Inc., Hengqin District, Zhuhai 519000, Guangdong, China.
  4. Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia.

PMID: 31906459 PMCID: PMC7023290 DOI: 10.3390/pharmaceutics12010035

Abstract

Recent studies have shown that β2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson's disease. The β2-AR agonist (R)-salbutamol, eutomer of rac-salbutamol, may hold therapeutic potential for Parkinson's disease (PD) following nasal administration. In this study, we use desorption electrospray ionization mass spectrometry (DESI-MS) to analyze spatial distribution of (R)-salbutamol in rat brain following nasal and intravenous administration. Here, we report that (R)-salbutamol efficiently deliver to the brain and had more drug dosage exposure in rat's brain through nasal route administration than that of intravenous route administration. In conclusion, administering (R)-salbutamol through nasal route of administration may hold advantages in improving spatial distribution and increased exposure of drug in brain.

Keywords: Parkinson’s disease; desorption electrospray ionization; nasal administration; salbutamol; β2-adrenergic receptor

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