Display options
Cite
Blangero J, Williams-Blangero S, Hixson JE. Assessing the effects of candidate genes on quantitative traits in primate populations. Am J Primatol. 1992;27(2):119-132doi: 10.1002/ajp.1350270207.
Blangero, J., Williams-Blangero, S., & Hixson, J. E. (1992). Assessing the effects of candidate genes on quantitative traits in primate populations. American journal of primatology, 27(2), 119-132. https://doi.org/10.1002/ajp.1350270207
Blangero, J, et al. "Assessing the effects of candidate genes on quantitative traits in primate populations." American journal of primatology vol. 27,2 (1992): 119-132. doi: https://doi.org/10.1002/ajp.1350270207
Blangero J, Williams-Blangero S, Hixson JE. Assessing the effects of candidate genes on quantitative traits in primate populations. Am J Primatol. 1992;27(2):119-132. doi: 10.1002/ajp.1350270207. PMID: 31948141.
Copy Download .nbib Format: NLM
Share it on

Am J Primatol. 1992;27(2):119-132. doi: 10.1002/ajp.1350270207.

Assessing the effects of candidate genes on quantitative traits in primate populations.

American journal of primatology

J Blangero, S Williams-Blangero, J E Hixson

Affiliations

  1. Southwest Foundation for Biomedical Research, San Antonio, Texas.

PMID: 31948141 DOI: 10.1002/ajp.1350270207

Abstract

Recent progress in molecular and biochemical genetics has led to the identification of numerous polymorphic candidate genes likely to be important in the determination of quantitative variation in physiological processes. In this paper, we review a statistical framework ("measured genotype analysis") for assessing the effects of candidate genes on quantitative traits in primate populations. We consider situations in which pedigree information is available and also when such knowledge is absent. We also extend the method to allow for cases in which there is missing candidate locus data. Using likelihood methods, we show how to test a variety of genetic hypotheses. As an example of this type of analysis, we analyzed serum levels of apolipoprotein AI and high density lipoprotein cholesterol, in 585 pedigreed baboons, as a function of genotypic variability at an APOA1 PstI RFLP locus. Our analyses revealed that 7.5% of the total phenotypic variation in apo AI serum levels and 2% of variation in HDL-C levels is attributable to this locus. Future use of such methods will help to clarify the genetic basis of normal variation in physiological traits. © 1992 Wiley-Liss, Inc.

Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company.

Keywords: Papio; apolipoprotein AI; high density lipoprotein cholesterol; measured genotype analysis; statistical genetics

References

  1. Blangero, J.; MacCluer, J. W.; Kammerer, C. M.; Mott, G. E.; Dyer, T. D.; McGill, H. C. Jr. Genetic analysis of apolipoprotoin A‐I in two dietary environments. American Journal of Human Genetics 47:414–428, 1990, - PubMed
  2. Boerwinkle, E.; Chakraborty, R.; Sing, C. F. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Annals of Human Genetics 50:181–194, 1986. - PubMed
  3. Boerwinkle, E.; Sing, C. F. The use of measured genotype information in the analysis of quantitative phenotypes in man. III. Simultaneous estimation of the frequencies and effects of the apolipoprotein E polymorphism and residual polygenetic effects on cholesterol, betalipoprotein, and triglyceride levels. Annals of Human Genetics 51:211–226, 1987. - PubMed
  4. Breslow, J. L. Genetic basis of lipoprotein disorders. Journal of Clinical Investigation 84:373–380, 1989. - PubMed
  5. Bruns, G. A.; Karathanasis, S. K.; Breslow, J. L. Human apolipoprotein A‐I‐C‐III gene complex is located on chromosome 11. Arteriosclerosis 4:97–102, 1984. - PubMed
  6. Cooper, D. N.; Clayton, J. F. DNA polymorphism and the study of disease association. Human Genetics 78:299–312, 1988. - PubMed
  7. Edwards, A. W. F. Likelihood. Cambridge, Cambridge University Press, 1972. - PubMed
  8. Elston, R. C. Segregation analysis. Pp. 63–120 in Advances in Human Genetics. H. Harris, K. Hirschorn, eds. New York, Plenum Press, 1981. - PubMed
  9. Elston, R. C.; Stewart, J., A general model for the genetic analysis of pedigree data. Human Heredity 21:523–542, 1971. - PubMed
  10. Falconer, D. S. Introduction To Quantitative Genetics. 2nd ed. London, Longman, 1981. - PubMed
  11. Ferrell, R. E. Application of molecular techniques to the study of human physiological variation. American Journal of Human Biology 1:545–553, 1989. - PubMed
  12. George, V. T.; Elston, R. C. Testing the association between polymorphic markers and quantitative traits in pedigrees. Genetic Epidemiology 4:193–201, 1987. - PubMed
  13. Hasstedt, S. J. A mixed model likelihood approximation for large pedigrees. Computers in Biomedical Research 15:295–307, 1982. - PubMed
  14. Hasstedt, S. J. Pedigree Analysis Package. Department of Human Genetics, University of Utah, Salt Lake City, 1989. - PubMed
  15. Hasstedt, S. J.; Cartwright, P. E. Pap—pedigree Analysis Package. Department Medical Biophysics and Computing, University of Utah, Technical Report No. 13. Salt Lake City, 1979. - PubMed
  16. Hixson, J. E. DNA markers in primate models of human disease. Genetica 73:85–90, 1987. - PubMed
  17. Hixson, J. E.; Borenstein, S.; Cox, L. A. PvuII RFLP for the lecithin‐cholesterol acyltransferase gene (LCAT) in baboons. Nucleic Acids Research 18:384, 1990. - PubMed
  18. Hixson, J. E.; Borenstein, S.; Cox, L. A.; Rainwater, D. L.; VandeBerg, J. L. The baboon gene for apolipoprotein A‐I: Characterization of a cDNA clone and identification of DNA polymorphisms for genetic studies of cholesterol metabolism. Gene 74:483–490, 1988. - PubMed
  19. Hixson, J. E.; Kammerer, C. M.; Cox, L. A.; Mott, G. E. Identification of an LDL receptor gene marker associated with altered levels of LDL‐cholesterol and apolipoprotein B in baboons. Arteriosclerosis 9:829–835, 1989. - PubMed
  20. Hopper, J. L.; Mathews, J. D. Extensions to multivariate normal models for pedigree analysis. Annals of Human Genetics 46:373–383, 1982. - PubMed
  21. Humphries, S. DNA polymorphisms of the apolipoprotein genes— their uses in the investigation of hyperlipidaemia and atherosclerosis. Atherosclerosis 72:89–108, 1988. - PubMed
  22. Karathanasis, S. K.; Zannis, V. I.; Breslow, J. L. Isolation and characterization of the human apolipoprotein A‐I gene. Proceedings of the National Academy of Science of the United States of America 80:6147–6151, 1983. - PubMed
  23. Kendall, M. G.; Stuart, A. The Advanced Theory of Statistics, Vol. 2. London, Charles Griffen, 1961. - PubMed
  24. Konigsberg, L. W.; Cheverud, J. M. Uncertain paternity in primate quantitative genetic studies, (this volume) - PubMed
  25. Little, R. J. A.; Rubin, D. B. Statistical Analysis with Missing Data. New York, John Wiley & Sons Inc., 1987. - PubMed
  26. Lusis, A. J. Genetic factors affecting blood lipoproteins: the candidate gene approach. Journal of Lipid Research 29:397–429, 1988. - PubMed
  27. MacCluer, J. W.; Kammerer, C. M.; Blangero, J.; Dyke, B.; Mott, G. E.; VandeBerg, J. L.; McGill, H. C. Jr. Pedigree analysis of HDL cholesterol concentratrion in baboons on two diets. American Journal of Human Genetics 43:401–413, 1988. - PubMed
  28. Munoz, A.; Rosner, B.; Carey, V. Regression analysis in the presence of heterogeneous intraclass correlations. Biometrics 42:653–658, 1986. - PubMed
  29. Rogers, J.; Kidd, J. R.; Murphy, P. D.; Castiglione, C. M.; Hixson, J. E.; Phillips‐Conroy, J.; Kidd, K. K. RFLPs for APOB in two subspecies of savanna baboons (Papio hamadryas anubis). Cytogenetics and Cell Genetics 46:683, 1988. - PubMed
  30. Williams‐Blangero, S.; VandeBerg, J. L.; Blangero, J.; Konigsberg, L.; Dyke, B. Genetic differntiation between baboon subspecies: Relevance for biomedical research. American Journal of Primatology 20:67–81, 1990. - PubMed

Publication Types