Display options
Cite
Ram N, Furqan S, Ahmed S. Is It T3 Thyrotoxicosis? A Case of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading to a Diagnosis of Multiple Myeloma. Case Rep Endocrinol. 2019;2019:5028534doi: 10.1155/2019/5028534.
Ram, N., Furqan, S., & Ahmed, S. (2019). Is It T3 Thyrotoxicosis? A Case of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading to a Diagnosis of Multiple Myeloma. Case reports in endocrinology, 20195028534. https://doi.org/10.1155/2019/5028534
Ram, Nanik, et al. "Is It T3 Thyrotoxicosis? A Case of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading to a Diagnosis of Multiple Myeloma." Case reports in endocrinology vol. 2019 (2019): 5028534. doi: https://doi.org/10.1155/2019/5028534
Ram N, Furqan S, Ahmed S. Is It T3 Thyrotoxicosis? A Case of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading to a Diagnosis of Multiple Myeloma. Case Rep Endocrinol. 2019 Dec 25;2019:5028534. doi: 10.1155/2019/5028534. eCollection 2019. PMID: 31949958; PMCID: PMC6944956.
Copy Download .nbib Format: NLM
Share it on

Case Rep Endocrinol. 2019 Dec 25;2019:5028534. doi: 10.1155/2019/5028534. eCollection 2019.

Is It T3 Thyrotoxicosis? A Case of Falsely Elevated Tri-Iodothyronine (T3) Levels Leading to a Diagnosis of Multiple Myeloma.

Case reports in endocrinology

Nanik Ram, Saira Furqan, Sibtain Ahmed

Affiliations

  1. Department of Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.
  2. Department of Pathology and Laboratory Medicine, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan.

PMID: 31949958 PMCID: PMC6944956 DOI: 10.1155/2019/5028534

Abstract

We are presenting a case of falsely elevated T3 levels in a patient due to interference from monoclonal immunoglobulins. A 56-year-old, clinically euthyroid man referred to the endocrinology clinic of the Aga Khan university, Karachi Pakistan, for possible T3 thyrotoxicosis after thyroid function tests revealed total T3 >12.32 nmol/L (reference range 0.6-2.79), normal TSH, and total T4 level. There was a mismatch in clinical and laboratory parameters and preliminary laboratory results were suggestive of thyroid binding globulin abnormalities. Further evaluation in this context unmasked multiple myeloma. The presence of monoclonal immunoglobulins can lead to assay interference and spurious results. To the best of our knowledge, this is the second case defining the cause of falsely elevated T3 levels, due to assay interferences with binding of T3 only to monoclonal immunoglobulins.

Copyright © 2019 Nanik Ram et al.

Conflict of interest statement

The authors declare that there are no conflicts of interest.

References

  1. Environ Health Perspect. 1999 Apr;107(4):273-8 - PubMed
  2. Best Pract Res Clin Endocrinol Metab. 2015 Oct;29(5):735-47 - PubMed
  3. Clin Chem. 1993 Aug;39(8):1739-42 - PubMed
  4. Case Rep Endocrinol. 2013;2013:739302 - PubMed
  5. Front Immunol. 2017 May 09;8:521 - PubMed
  6. Clin Chem. 1990 Jun;36(6):829 - PubMed

Publication Types