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Kakraba S, Ayyadevara S, Penthala NR, et al. A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease. Front Mol Neurosci. 2019;12:310doi: 10.3389/fnmol.2019.00310.
Kakraba, S., Ayyadevara, S., Penthala, N. R., Balasubramaniam, M., Ganne, A., Liu, L., Alla, R., Bommagani, S. B., Barger, S. W., Griffin, W. S. T., Crooks, P. A., & Shmookler Reis, R. J. (2019). A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease. Frontiers in molecular neuroscience, 12310. https://doi.org/10.3389/fnmol.2019.00310
Kakraba, Samuel, et al. "A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease." Frontiers in molecular neuroscience vol. 12 (2019): 310. doi: https://doi.org/10.3389/fnmol.2019.00310
Kakraba S, Ayyadevara S, Penthala NR, Balasubramaniam M, Ganne A, Liu L, Alla R, Bommagani SB, Barger SW, Griffin WST, Crooks PA, Shmookler Reis RJ. A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease. Front Mol Neurosci. 2019 Dec 12;12:310. doi: 10.3389/fnmol.2019.00310. eCollection 2019. PMID: 31920540; PMCID: PMC6920216.
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Front Mol Neurosci. 2019 Dec 12;12:310. doi: 10.3389/fnmol.2019.00310. eCollection 2019.

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease.

Frontiers in molecular neuroscience

Samuel Kakraba, Srinivas Ayyadevara, Narsimha Reddy Penthala, Meenakshisundaram Balasubramaniam, Akshatha Ganne, Ling Liu, Ramani Alla, Shoban Babu Bommagani, Steven W Barger, W Sue T Griffin, Peter A Crooks, Robert J Shmookler Reis

Affiliations

  1. BioInformatics Program, University of Arkansas for Medical Sciences and University of Arkansas at Little Rock, Little Rock, AR, United States.
  2. Central Arkansas Veterans Healthcare Service, Little Rock, AR, United States.
  3. Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
  4. Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

PMID: 31920540 PMCID: PMC6920216 DOI: 10.3389/fnmol.2019.00310

Abstract

Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology of neurological diseases. We synthesized and tested analogs of the naturally occurring tubulin-binding compound, combretastatin A-4. One such analog, PNR502, markedly reduced the quantity of Alzheimer-associated amyloid aggregates in the BRI-Aβ

Copyright © 2019 Kakraba, Ayyadevara, Penthala, Balasubramaniam, Ganne, Liu, Alla, Bommagani, Barger, Griffin, Crooks and Shmookler Reis.

Keywords: Alzheimer’s disease; GFAP (Glial Fibrillary Acidic Protein); anti-aggregant activity; combretastatin; protein aggregation; tubulin

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