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Bornschein G, Brachtendorf S, Schmidt H. Developmental Increase of Neocortical Presynaptic Efficacy . Front Synaptic Neurosci. 2020;11:36doi: 10.3389/fnsyn.2019.00036.
Bornschein, G., Brachtendorf, S., & Schmidt, H. (2019). Developmental Increase of Neocortical Presynaptic Efficacy . Frontiers in synaptic neuroscience, 1136. https://doi.org/10.3389/fnsyn.2019.00036
Bornschein, Grit, et al. "Developmental Increase of Neocortical Presynaptic Efficacy ." Frontiers in synaptic neuroscience vol. 11 (2019): 36. doi: https://doi.org/10.3389/fnsyn.2019.00036
Bornschein G, Brachtendorf S, Schmidt H. Developmental Increase of Neocortical Presynaptic Efficacy . Front Synaptic Neurosci. 2020 Jan 15;11:36. doi: 10.3389/fnsyn.2019.00036. eCollection 2019. PMID: 32009937; PMCID: PMC6974464.
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Front Synaptic Neurosci. 2020 Jan 15;11:36. doi: 10.3389/fnsyn.2019.00036. eCollection 2019.

Developmental Increase of Neocortical Presynaptic Efficacy .

Frontiers in synaptic neuroscience

Grit Bornschein, Simone Brachtendorf, Hartmut Schmidt

Affiliations

  1. Carl-Ludwig-Institute for Physiology, Medical Faculty, University of Leipzig, Leipzig, Germany.

PMID: 32009937 PMCID: PMC6974464 DOI: 10.3389/fnsyn.2019.00036

Abstract

The efficacy of neocortical synapses to transmit during bursts of action potentials (APs) increases during development but the underlying mechanisms are largely unclear. We investigated synaptic efficacy at synapses between layer 5 pyramidal neurons (L5PNs) during development, using paired recordings, presynaptic two-photon Ca

Copyright © 2020 Bornschein, Brachtendorf and Schmidt.

Keywords: action potential trains; failures; layer 5 pyramidal neurons; paired-pulse ratios; presynaptic calcium signals; replenishment; synaptic efficacy; vesicle pools

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