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Blottner D, Hastermann M, Weber R, et al. Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest. Front Physiol. 2020;10:1527doi: 10.3389/fphys.2019.01527.
Blottner, D., Hastermann, M., Weber, R., Lenz, R., Gambara, G., Limper, U., Rittweger, J., Bosutti, A., Degens, H., & Salanova, M. (2019). Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest. Frontiers in physiology, 101527. https://doi.org/10.3389/fphys.2019.01527
Blottner, Dieter, et al. "Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest." Frontiers in physiology vol. 10 (2019): 1527. doi: https://doi.org/10.3389/fphys.2019.01527
Blottner D, Hastermann M, Weber R, Lenz R, Gambara G, Limper U, Rittweger J, Bosutti A, Degens H, Salanova M. Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest. Front Physiol. 2020 Jan 15;10:1527. doi: 10.3389/fphys.2019.01527. eCollection 2019. PMID: 32009969; PMCID: PMC6974579.
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Front Physiol. 2020 Jan 15;10:1527. doi: 10.3389/fphys.2019.01527. eCollection 2019.

Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest.

Frontiers in physiology

Dieter Blottner, Maria Hastermann, Robert Weber, Regina Lenz, Guido Gambara, Ulrich Limper, Jörn Rittweger, Alessandra Bosutti, Hans Degens, Michele Salanova

Affiliations

  1. Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Integrative Neuroanatomy, Berlin, Germany.
  2. NeuroMuscular Group, Center of Space Medicine and Extreme Environments, Berlin, Germany.
  3. Department of Movement and Neurosciences, German Sports University, Cologne, Germany.
  4. Charité Comprehensive Cancer Center, Berlin, Germany.
  5. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  6. German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.
  7. Department of Anesthesiology and Intensive Care Medicine, Merheim Medical Center, Hospitals of Cologne, University of Witten/Herdecke, Cologne, Germany.
  8. Department of Life Sciences, University of Trieste, Trieste, Italy.
  9. Research Centre for Musculoskeletal Science & Sports Medicine, Manchester Metropolitan University, Manchester, United Kingdom.
  10. Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania.

PMID: 32009969 PMCID: PMC6974579 DOI: 10.3389/fphys.2019.01527

Abstract

Identification of countermeasures able to prevent disuse-induced muscle wasting is crucial to increase performance of crew members during space flight as well as ameliorate patient's clinical outcome after long immobilization periods. We report on the outcome of short but high-impact reactive jumps (JUMP) as countermeasure during 60 days of 6° head-down tilt (HDT) bed rest on myofiber size, type composition, capillarization, and oxidative capacity in tissue biopsies (pre/post/recovery) from the knee extensor

Copyright © 2020 Blottner, Hastermann, Weber, Lenz, Gambara, Limper, Rittweger, Bosutti, Degens and Salanova.

Keywords: bed rest; capillarization; countermeasure; disuse; muscle atrophy; oxidative capacity

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