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Sayoh I, Rusling DA, Brown T, et al. DNA Structural Changes Induced by Intermolecular Triple Helix Formation. ACS Omega. 2020;5(3):1679-1687doi: 10.1021/acsomega.9b03776.
Sayoh, I., Rusling, D. A., Brown, T., & Fox, K. R. (2020). DNA Structural Changes Induced by Intermolecular Triple Helix Formation. ACS omega, 5(3), 1679-1687. https://doi.org/10.1021/acsomega.9b03776
Sayoh, Ibrahim, et al. "DNA Structural Changes Induced by Intermolecular Triple Helix Formation." ACS omega vol. 5,3 (2020): 1679-1687. doi: https://doi.org/10.1021/acsomega.9b03776
Sayoh I, Rusling DA, Brown T, Fox KR. DNA Structural Changes Induced by Intermolecular Triple Helix Formation. ACS Omega. 2020 Jan 15;5(3):1679-1687. doi: 10.1021/acsomega.9b03776. eCollection 2020 Jan 28. PMID: 32010842; PMCID: PMC6990630.
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ACS Omega. 2020 Jan 15;5(3):1679-1687. doi: 10.1021/acsomega.9b03776. eCollection 2020 Jan 28.

DNA Structural Changes Induced by Intermolecular Triple Helix Formation.

ACS omega

Ibrahim Sayoh, David A Rusling, Tom Brown, Keith R Fox

Affiliations

  1. School of Biological Sciences, Life Sciences Building 85, University of Southampton, Southampton SO17 1BJ, U.K.
  2. Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.

PMID: 32010842 PMCID: PMC6990630 DOI: 10.1021/acsomega.9b03776

Abstract

DNase I footprints of intermolecular DNA triplexes are often accompanied by enhanced cleavage at the 3'-end of the target site at the triplex-duplex junction. We have systematically studied the sequence dependence of this effect by examining oligonucleotide binding to sites flanked by each base in turn. For complexes with a terminal T.AT triplet, the greatest enhancement is seen with ApC, followed by ApG and ApT, with the weakest enhancement at ApA. Similar DNase I enhancements were observed for a triplex with a terminal C

Copyright © 2020 American Chemical Society.

Conflict of interest statement

The authors declare no competing financial interest.

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