Display options
Cite
Ou M, Zhao W, Liu J, et al. The General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability. iScience. 2019;23(1):100760doi: 10.1016/j.isci.2019.100760.
Ou, M., Zhao, W., Liu, J., Liang, P., Huang, H., Yu, H., Zhu, T., & Zhou, C. (2020). The General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability. iScience, 23(1), 100760. https://doi.org/10.1016/j.isci.2019.100760
Ou, Mengchan, et al. "The General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability." iScience vol. 23,1 (2020): 100760. doi: https://doi.org/10.1016/j.isci.2019.100760
Ou M, Zhao W, Liu J, Liang P, Huang H, Yu H, Zhu T, Zhou C. The General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability. iScience. 2020 Jan 24;23(1):100760. doi: 10.1016/j.isci.2019.100760. Epub 2019 Dec 10. PMID: 31926429; PMCID: PMC6956953.
Copy Download .nbib Format: NLM
Share it on

iScience. 2020 Jan 24;23(1):100760. doi: 10.1016/j.isci.2019.100760. Epub 2019 Dec 10.

The General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability.

iScience

Mengchan Ou, Wenling Zhao, Jin Liu, Peng Liang, Han Huang, Hai Yu, Tao Zhu, Cheng Zhou

Affiliations

  1. Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, P.R. China; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, P.R. China.
  2. Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, P.R. China.
  3. Department of Anesthesiology, West China Second Hospital of Sichuan University, Chengdu 610041, Sichuan, P.R. China.
  4. Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, P.R. China; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, P.R. China. Electronic address: [email protected].

PMID: 31926429 PMCID: PMC6956953 DOI: 10.1016/j.isci.2019.100760

Abstract

Volatile anesthetics induce hyperactivity during induction while producing anesthesia at higher concentrations. They also bidirectionally modulate many neuronal functions. However, the neuronal mechanism is unclear. The effects of isoflurane on sodium channel currents were analyzed in acute mouse brain slices, including sodium leak (NALCN) currents and voltage-gated sodium channels (Na

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Keywords: Anesthesiology; Neuroscience

Conflict of interest statement

Declaration of Interests The authors declare no conflict of interests.

References

  1. Front Cell Neurosci. 2014 May 20;8:132 - PubMed
  2. J Pharmacol Exp Ther. 2006 Jan;316(1):208-15 - PubMed
  3. J Neurophysiol. 1979 May;42(3):889-95 - PubMed
  4. Anesthesiology. 2004 Mar;100(3):663-70 - PubMed
  5. Trends Pharmacol Sci. 2005 Oct;26(10):503-10 - PubMed
  6. Nat Neurosci. 2002 Oct;5(10):979-84 - PubMed
  7. Bull Math Biol. 1990;52(1-2):25-71; discussion 5-23 - PubMed
  8. Anesth Analg. 2008 Nov;107(5):1689-703 - PubMed
  9. Neurosci Lett. 2014 Jan 24;559:30-3 - PubMed
  10. Front Pharmacol. 2012 Mar 30;3:50 - PubMed
  11. Acta Anaesthesiol Scand. 2015 Jan;59(1):78-84 - PubMed
  12. Korean J Anesthesiol. 2010 Jul;59(1):3-8 - PubMed
  13. Br J Anaesth. 2013 Apr;110(4):592-9 - PubMed
  14. Br J Anaesth. 2014 Oct;113(4):634-43 - PubMed
  15. Int J Dev Neurosci. 2016 Feb;48:38-49 - PubMed
  16. Prog Brain Res. 1990;83:161-87 - PubMed
  17. J Pharmacol Exp Ther. 2019 May;369(2):200-211 - PubMed
  18. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6704-9 - PubMed
  19. Neuropharmacology. 2011 Mar;60(4):701-10 - PubMed
  20. Mol Pharmacol. 2003 Aug;64(2):373-81 - PubMed
  21. Neurotox Res. 2018 Aug;34(2):188-197 - PubMed
  22. Neuron. 2013 Feb 20;77(4):696-711 - PubMed
  23. Anesth Analg. 2003 Sep;97(3):718-40 - PubMed
  24. Nat Rev Neurosci. 2008 May;9(5):370-86 - PubMed
  25. Br J Anaesth. 2017 Oct 1;119(4):573-582 - PubMed
  26. PLoS Genet. 2010 Aug 12;6(8): - PubMed
  27. Epilepsy Curr. 2007 Jan-Feb;7(1):15-22 - PubMed
  28. Cell. 2007 Apr 20;129(2):371-83 - PubMed
  29. Channels (Austin). 2017 Nov 2;11(6):534-554 - PubMed
  30. Br J Anaesth. 2009 Jul;103(1):61-9 - PubMed
  31. Anesthesiology. 2019 Jul;131(1):94-104 - PubMed
  32. Curr Neuropharmacol. 2010 Mar;8(1):2-9 - PubMed
  33. Br J Anaesth. 1988 May;60(6):680-91 - PubMed
  34. J Physiol. 2014 Nov 15;592(22):4825-38 - PubMed
  35. Eur J Pharmacol. 1987 Jul 2;139(1):43-52 - PubMed
  36. Br J Anaesth. 2017 Nov 1;119(5):1047-1054 - PubMed
  37. Brain. 2012 Sep;135(Pt 9):2585-612 - PubMed
  38. Anesthesiology. 2009 Sep;111(3):591-9 - PubMed
  39. PLoS One. 2014 Aug 28;9(8):e105340 - PubMed
  40. Anesth Analg. 2014 Sep;119(3):558-69 - PubMed
  41. Eur J Neurosci. 1998 Aug;10(8):2547-56 - PubMed
  42. Nat Neurosci. 1999 May;2(5):422-6 - PubMed
  43. Nat Rev Neurosci. 2007 Jun;8(6):451-65 - PubMed
  44. Ann Clin Transl Neurol. 2016 Oct 11;3(11):876-883 - PubMed
  45. Cochrane Database Syst Rev. 2014 Sep 12;(9):CD007084 - PubMed
  46. Brain Res. 2008 Mar 4;1197:32-9 - PubMed
  47. Curr Biol. 2007 Apr 3;17(7):624-9 - PubMed
  48. Br J Anaesth. 2010 Feb;104(2):216-23 - PubMed
  49. Int J Dev Neurosci. 2014 Oct;37:87-93 - PubMed
  50. J Neurosci. 2005 Oct 19;25(42):9704-20 - PubMed
  51. Reg Anesth Pain Med. 2011 Nov-Dec;36(6):553-9 - PubMed
  52. Anesthesiology. 1973 Jun;38(6):564-82 - PubMed
  53. J Neurosci. 2016 Aug 3;36(31):8174-87 - PubMed
  54. PLoS One. 2012;7(6):e39346 - PubMed
  55. Hippocampus. 1998;8(6):608-19 - PubMed
  56. Genetics. 1997 Oct;147(2):701-12 - PubMed
  57. Eur J Pharmacol. 2014 Jan 15;723:29-37 - PubMed
  58. J Neurogenet. 2000 Apr;14(1):25-42 - PubMed
  59. Pain. 2018 Sep;159(9):1719-1730 - PubMed
  60. J Neurosci. 2010 Jul 7;30(27):9324-34 - PubMed
  61. Anesth Analg. 2009 Oct;109(4):1253-62 - PubMed
  62. J Neurophysiol. 2015 Oct;114(4):2376-89 - PubMed
  63. Prog Neurobiol. 2014 Nov;122:24-44 - PubMed
  64. Neuron. 2010 Nov 4;68(3):488-99 - PubMed
  65. Mol Neurobiol. 2017 Aug;54(6):4353-4364 - PubMed
  66. Anesthesiology. 2002 Nov;97(5):1209-17 - PubMed

Publication Types