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Duran CE, Ramírez A, Posada JG, et al. Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country. Int J Nephrol. 2019;2019:7076326doi: 10.1155/2019/7076326.
Duran, C. E., Ramírez, A., Posada, J. G., Schweineberg, J., Mesa, L., Pachajoa, H., Estacio, M., Manzi, E., Aros, V., Díaz, L., & Garcia, V. H. (2019). Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country. International journal of nephrology, 20197076326. https://doi.org/10.1155/2019/7076326
Duran, Carlos E, et al. "Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country." International journal of nephrology vol. 2019 (2019): 7076326. doi: https://doi.org/10.1155/2019/7076326
Duran CE, Ramírez A, Posada JG, Schweineberg J, Mesa L, Pachajoa H, Estacio M, Manzi E, Aros V, Díaz L, Garcia VH. Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country. Int J Nephrol. 2019 Dec 18;2019:7076326. doi: 10.1155/2019/7076326. eCollection 2019. PMID: 31929905; PMCID: PMC6935820.
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Int J Nephrol. 2019 Dec 18;2019:7076326. doi: 10.1155/2019/7076326. eCollection 2019.

Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country.

International journal of nephrology

Carlos E Duran, Alejandro Ramírez, Juan G Posada, Johanna Schweineberg, Liliana Mesa, Harry Pachajoa, Mayra Estacio, Eliana Manzi, Vanessa Aros, Lorena Díaz, Victor H Garcia

Affiliations

  1. Department of Nephrology, Fundacion Valle del Lili, Cali, Colombia.
  2. Health Sciences Faculty, Icesi University, Cali, Colombia.
  3. Department of Basic Medical Sciences, Center for Research on Congenital Anomalies and Rare Diseases (CIACER), Icesi University, Cali, Colombia.
  4. Clinical Research Center, Fundación Valle del Lili, Cali, Colombia.

PMID: 31929905 PMCID: PMC6935820 DOI: 10.1155/2019/7076326

Abstract

INTRODUCTION: In Colombia, the genetic background of the populations was shaped by different levels of admixture between Natives, European, and Africans. Approximately 35.363 patients have diagnosed chronic kidney disease and according to population studies, 10.4% of these patients are Afro-descendant. We aim to assess the frequency of APOL1 variants G1 and G2 in Afro-descendant patients with ESRD treated at la Fundacion Valle del Lili University Hospital in Cali, Colombia.

METHODS: This is an observational cross-sectional study. Afro-descendant patients with ESRD in waitlist or recipients of kidney transplant were evaluated. Clinical data were collected from the electronic medical records. Genotyping was carried out by amplification of the exon 7 of the APOL1 gene. For the identification of risk genotypes, the bioinformatics tool BLAST was used.

RESULTS: We enrolled 102 participants. The frequency of APOL1 risk variants was 67.2%, in which 24.5% (

Copyright © 2019 Carlos E. Duran et al.

Conflict of interest statement

The authors declare that there are no conflicts of interest.

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