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Samieirad S, Mianbandi V, Salari Sedigh H, et al. Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study. J Maxillofac Oral Surg. 2019;19(1):85-92doi: 10.1007/s12663-019-01221-0.
Samieirad, S., Mianbandi, V., Salari Sedigh, H., Hosseini-Abrishami, M., Shiezadeh, F., Bagheri, H., Tohidi, E., & Saghravanian, N. (2020). Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study. Journal of maxillofacial and oral surgery, 19(1), 85-92. https://doi.org/10.1007/s12663-019-01221-0
Samieirad, Sahand, et al. "Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study." Journal of maxillofacial and oral surgery vol. 19,1 (2020): 85-92. doi: https://doi.org/10.1007/s12663-019-01221-0
Samieirad S, Mianbandi V, Salari Sedigh H, Hosseini-Abrishami M, Shiezadeh F, Bagheri H, Tohidi E, Saghravanian N. Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study. J Maxillofac Oral Surg. 2020 Mar;19(1):85-92. doi: 10.1007/s12663-019-01221-0. Epub 2019 Mar 27. PMID: 31988569; PMCID: PMC6954918.
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J Maxillofac Oral Surg. 2020 Mar;19(1):85-92. doi: 10.1007/s12663-019-01221-0. Epub 2019 Mar 27.

Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study.

Journal of maxillofacial and oral surgery

Sahand Samieirad, Vajiheh Mianbandi, Hamideh Salari Sedigh, Majid Hosseini-Abrishami, Farid Shiezadeh, Hossein Bagheri, Elahe Tohidi, Nasrollah Saghravanian

Affiliations

  1. 1Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  2. 2Oral and Maxillofacial Surgery Department, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. 3Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
  4. 4Dental Materials Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
  5. Oral and Maxillofacial Radiologist, Mashhad, Iran.

PMID: 31988569 PMCID: PMC6954918 DOI: 10.1007/s12663-019-01221-0

Abstract

INTRODUCTION AND AIM: The aim of this study was to evaluate the effect of two concentrations of caffeine (1.5% and 3%) powder added to Bio-Oss xenograft on bone healing rate of iatrogenic mandibular defects in dogs.

MATERIALS AND METHOD: The researchers implemented a pilot study on ten male adult mongrel dogs. Two 4-mm circular critical-sized defects were trephined on each side of the mandibular body (a total of 4 defects for each dog). One of the defects remained empty as a control group. The other three defects in each case were randomly filled with 1.5% or 3% caffeinated Bio-Oss or pure Bio-Oss. The mandible specimens were sent for histological and histomorphometric assessments, 4 months postoperatively. Our predictor variable was the type of bone substitute. The study outcomes were new bone formation, angiogenesis, and fibrosis. The

RESULTS: The histological assessment showed that the administration of 1.5% caffeinated Bio-Oss to mandibular defects caused more angiogenesis and more new bone formation as well as less fibrosis compared to the other groups (

CONCLUSION: This study suggested that the application of 1.5% caffeinated Bio-Oss in bone defects of dogs resulted in the higher new bone formation. However, further clinical trials are needed to support its relevancy.

© The Association of Oral and Maxillofacial Surgeons of India 2019.

Keywords: Bio-Oss; Caffeine; New bone formation; Xenograft

Conflict of interest statement

Conflict of interestThe authors declare that they have no conflicts of interest.

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