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Wang H, Daggy BP. The Role of Fish Oil in Inflammatory Eye Diseases. Biomed Hub. 2017;2(1):1-12doi: 10.1159/000455818.
Wang, H., & Daggy, B. P. (2017). The Role of Fish Oil in Inflammatory Eye Diseases. Biomedicine hub, 2(1), 1-12. https://doi.org/10.1159/000455818
Wang, Hong, and Daggy, Bruce P. "The Role of Fish Oil in Inflammatory Eye Diseases." Biomedicine hub vol. 2,1 (2017): 1-12. doi: https://doi.org/10.1159/000455818
Wang H, Daggy BP. The Role of Fish Oil in Inflammatory Eye Diseases. Biomed Hub. 2017 Feb 21;2(1):1-12. doi: 10.1159/000455818. eCollection 2017. PMID: 31988905; PMCID: PMC6945974.
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Biomed Hub. 2017 Feb 21;2(1):1-12. doi: 10.1159/000455818. eCollection 2017.

The Role of Fish Oil in Inflammatory Eye Diseases.

Biomedicine hub

Hong Wang, Bruce P Daggy

Affiliations

  1. Research and Development, Shaklee Corporation, Pleasanton, CA, USA.

PMID: 31988905 PMCID: PMC6945974 DOI: 10.1159/000455818

Abstract

Consumption of fish oil is associated with reduced morbidity and mortality of cardiovascular diseases and also reduces the severity of many other inflammatory diseases and autoimmune disorders. The beneficial effects are attributed to the anti-inflammatory effects of the omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oils. The mechanism of the anti-inflammatory effects was long thought to be by modulating the production of proinflammatory mediators, including prostaglandins, thromboxanes, and leukotrienes. Recent advances in research into the novel lipid mediators (resolvins, protectins, and maresins) derived from EPA and DHA and their role in the resolution of inflammation have shed new light on the pleiotropic nature of these fatty acids. In this review, we focus on the effects of EPA and DHA from fish oil in the treatment of two common inflammatory eye diseases - dry eye disease and age-related macular degeneration. Evidence from recent studies lends support to a role of fish oil in the treatment of these two eye diseases.

Copyright © 2017 by S. Karger AG, Basel.

Keywords: Age-related macular degeneration; Anti-inflammation; Dry eye disease; Fish oil; Omega-3 Index; Omega-3 fatty acids

References

  1. Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):2010-9 - PubMed
  2. Ophthalmology. 2013 Nov;120(11):2191-6 - PubMed
  3. Ophthalmology. 2016 Aug;123(8):1751-1761 - PubMed
  4. Mol Vis. 2016 Feb 27;22:189-202 - PubMed
  5. Curr Opin Ophthalmol. 2014 May;25(3):186-90 - PubMed
  6. FASEB J. 2015 Nov;29(11):4579-88 - PubMed
  7. Invest Ophthalmol Vis Sci. 2013 Jun 12;54(6):4109-16 - PubMed
  8. Arch Ophthalmol. 2009 Jan;127(1):110-2 - PubMed
  9. Control Clin Trials. 1999 Dec;20(6):573-600 - PubMed
  10. Circulation. 2002 Nov 19;106(21):2747-57 - PubMed
  11. Curr Cardiol Rep. 2010 Nov;12(6):503-8 - PubMed
  12. Trends Mol Med. 2015 Dec;21(12):736-748 - PubMed
  13. JAMA Ophthalmol. 2014 Feb;132(2):142-9 - PubMed
  14. Biomed Res. 2013;34(5):215-20 - PubMed
  15. Exp Eye Res. 2010 Oct;91(4):478-85 - PubMed
  16. Semin Immunol. 2015 May;27(3):200-15 - PubMed
  17. Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):27-31 - PubMed
  18. Prev Med. 2004 Jul;39(1):212-20 - PubMed
  19. Cornea. 2015 Apr;34(4):413-20 - PubMed
  20. Med Sci Monit. 2014 Sep 06;20:1583-9 - PubMed
  21. Immunity. 2014 Mar 20;40(3):315-27 - PubMed
  22. Eur J Ophthalmol. 2009 Jan-Feb;19(1):100-6 - PubMed
  23. J Ophthalmol. 2015;2015:523027 - PubMed
  24. Invest Ophthalmol Vis Sci. 2010 Feb;51(2):804-10 - PubMed
  25. Br J Ophthalmol. 2016 Feb;100(2):227-34 - PubMed
  26. Dtsch Arztebl Int. 2015 Jan 30;112(5):71-81; quiz 82 - PubMed
  27. Prog Retin Eye Res. 2005 Jan;24(1):87-138 - PubMed
  28. Am J Clin Nutr. 2005 Oct;82(4):887-93 - PubMed
  29. Korean J Physiol Pharmacol. 2009 Aug;13(4):301-7 - PubMed
  30. Am J Clin Nutr. 2006 Feb;83(2):331-42 - PubMed
  31. Cornea. 2016 Sep;35(9):1185-91 - PubMed
  32. Optom Vis Sci. 2015 Sep;92(9):948-56 - PubMed
  33. Clin Interv Aging. 2013;8:1133-8 - PubMed
  34. J Clin Lipidol. 2013 Sep-Oct;7(5):433-40 - PubMed
  35. Br J Ophthalmol. 2016 Mar;100(3):300-6 - PubMed
  36. Cont Lens Anterior Eye. 2015 Jun;38(3):206-10 - PubMed
  37. Int J Ophthalmol. 2013 Dec 18;6(6):811-6 - PubMed
  38. Curr Eye Res. 2016 Oct;41(10):1274-1280 - PubMed
  39. J Lipid Res. 2016 Mar;57(3):499-508 - PubMed
  40. JAMA. 2013 May 15;309(19):2005-15 - PubMed
  41. Ocul Surf. 2007 Apr;5(2):179-93 - PubMed
  42. J Lipid Res. 2010 May;51(5):879-91 - PubMed
  43. Arch Ophthalmol. 2008 Sep;126(9):1274-9 - PubMed
  44. Invest Ophthalmol Vis Sci. 2011 Sep 27;52(10):7423-31 - PubMed
  45. Biochim Biophys Acta. 2015 Apr;1851(4):469-84 - PubMed
  46. Arch Ophthalmol. 2007 May;125(5):671-9 - PubMed
  47. Nat Immunol. 2001 Jul;2(7):612-9 - PubMed
  48. Biomed Res Int. 2014;2014:768026 - PubMed
  49. Ophthalmology. 2012 Nov;119(11):2282-9 - PubMed
  50. Ophthalmic Res. 2015;55(2):62-9 - PubMed
  51. Am J Clin Nutr. 2008 Jun;87(6):1997S-2002S - PubMed
  52. Clin Biochem. 2010 Feb;43(3):338-40 - PubMed
  53. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4328-34 - PubMed
  54. Am J Clin Nutr. 2009 Dec;90(6):1601-7 - PubMed
  55. Nat Med. 2007 Jul;13(7):868-873 - PubMed
  56. Eye Contact Lens. 2016 Jul;42(4):231-6 - PubMed
  57. Graefes Arch Clin Exp Ophthalmol. 2013 Dec;251(12):2711-23 - PubMed
  58. J Am Heart Assoc. 2013 Nov 19;2(6):e000513 - PubMed
  59. Invest Ophthalmol Vis Sci. 1984 Jun;25(6):660-73 - PubMed
  60. Ophthalmology. 2013 Aug;120(8):1619-31 - PubMed
  61. Am J Ophthalmol. 2014 Nov;158(5):1071-78 - PubMed

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