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Ilieş RF, Cătană A, Popp R, et al. The influence of GSTT/GSTM null genotypes in scarring. Med Pharm Rep. 2019;92:S73-S77doi: 10.15386/mpr-1513.
Ilieş, R. F., Cătană, A., Popp, R., Aioanei, C. S., Halmagyi, S. R., Lukacs, I., Tokes, R. E., Rotar, I. C., & Pop, I. V. (2019). The influence of GSTT/GSTM null genotypes in scarring. Medicine and pharmacy reports, 92S73-S77. https://doi.org/10.15386/mpr-1513
Ilieş, Roxana Flavia, et al. "The influence of GSTT/GSTM null genotypes in scarring." Medicine and pharmacy reports vol. 92 (2019): S73-S77. doi: https://doi.org/10.15386/mpr-1513
Ilieş RF, Cătană A, Popp R, Aioanei CS, Halmagyi SR, Lukacs I, Tokes RE, Rotar IC, Pop IV. The influence of GSTT/GSTM null genotypes in scarring. Med Pharm Rep. 2019 Dec;92:S73-S77. doi: 10.15386/mpr-1513. Epub 2019 Dec 15. PMID: 31989113; PMCID: PMC6978933.
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Med Pharm Rep. 2019 Dec;92:S73-S77. doi: 10.15386/mpr-1513. Epub 2019 Dec 15.

The influence of GSTT/GSTM null genotypes in scarring.

Medicine and pharmacy reports

Roxana Flavia Ilieş, Andreea Cătană, Radu Popp, Casian Simon Aioanei, Salomea-Ruth Halmagyi, Istvan Lukacs, Reka-Eniko Tokes, Ioana Cristina Rotar, Ioan Victor Pop

Affiliations

  1. Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj- Napoca, Romania.
  2. Ion Chiricu?? Oncological Institute, Cluj-Napoca, Romania.
  3. 1 Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.

PMID: 31989113 PMCID: PMC6978933 DOI: 10.15386/mpr-1513

Abstract

BACKGROUND AND AIMS: The process of scarring is a common denominator of interest for the medical field. From general medicine to dentistry, pathological scar tissue represents a challenge in providing optimal care to a patient. The present study aims to investigate whether a systemically reduced antioxidant potential, revealed by null isoforms of glutathione S transferase, affects the process of scarring in a group of female patients.

METHODS: The study is based on a group of 54 patients with physiological scars after a 6-month observation period, as well as 18 patients with hypertrophic or atrophic scars. Peripheral venous blood was collected, from which DNA was extracted using a commercial kit. Genotyping followed a Multiplex PCR protocol for GSTT1/GSTM1.

RESULTS: In a dominant model, the combination of wild type (heterozygous or homozygous) GSTT1 and GSTM1 was negatively associated with pathological scarring, with the wild type (heterozygous or homozygous) GSTM1 genotype being potentially responsible for this effect. Other factors affecting pathological scarring were investigated: family history, phototype, as well as scores on the POSAS and SCAR scales.

CONCLUSIONS: The presence of GSTT1 and GSTM1 alleles brings forward an increased antioxidant capacity, serving as a protective factor for patients during scar formation.

Keywords: genotype; glutathione S-transferase M1; glutathione S-transferase T1; scarring

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