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Zhang XW, Deng YJ, Zhou L, et al. Epithelioid sarcoma of the scalp: a case report and literature review. Int J Clin Exp Pathol. 2019;12(10):3908-3914
Zhang, X. W., Deng, Y. J., Zhou, L., & Deng, H. (2019). Epithelioid sarcoma of the scalp: a case report and literature review. International journal of clinical and experimental pathology, 12(10), 3908-3914.
Zhang, Xing-Wei, et al. "Epithelioid sarcoma of the scalp: a case report and literature review." International journal of clinical and experimental pathology vol. 12,10 (2019): 3908-3914.
Zhang XW, Deng YJ, Zhou L, Deng H. Epithelioid sarcoma of the scalp: a case report and literature review. Int J Clin Exp Pathol. 2019 Oct 01;12(10):3908-3914. eCollection 2019. PMID: 31933781; PMCID: PMC6949740.
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Int J Clin Exp Pathol. 2019 Oct 01;12(10):3908-3914. eCollection 2019.

Epithelioid sarcoma of the scalp: a case report and literature review.

International journal of clinical and experimental pathology

Xing-Wei Zhang, Yan-Juan Deng, Lv Zhou, Huan Deng

Affiliations

  1. Medical College, Nanchang University Nanchang, Jiangxi, China.
  2. Department of Pathology, The Fourth Affiliated Hospital of Nanchang University Nanchang, Jiangxi, China.
  3. Molecular Medicine and Genetics Center, The Fourth Affiliated Hospital of Nanchang University Nanchang, Jiangxi, China.
  4. Renmin Institute of Forensic Medicine in Jiangxi Nanchang, Jiangxi, China.

PMID: 31933781 PMCID: PMC6949740

Abstract

Epithelioid sarcoma (ES) is an aggressive mesenchymal tumor exhibiting bi-directional phenotypes. According to its proclivity for different sites, ES can be subdivided into two categories: distal and proximal variants. Proximal ES often affects the truncal tissue, thighs, head, and neck. Accumulating evidence indicates that several locations in the head, including the orbital, gingival, and nasal cavities, are involved in ES. However, the underlying mechanisms of ES carcinogenesis and progression are largely unknown, including and especially the reason why the tumor cells are positive for both epithelial and mesenchymal classical markers. Thus, we wish to share a rare case of ES in the scalp and its clinical and molecular features. Only 9 cases to date have been reported. An 80-years-old man had sustained a painful swollen mass in his scalp for three months. A diagnosis of epithelioid sarcoma was established based on the combination of the histopathological and immunohistochemical findings. The tumor cells were positive for both mesenchymal (vimentin and S100) and epithelial markers (pan-cytokeratin). This case suggests that ES can be derived from the soft tissue of the scalp. The tumor cells co-expressed biomarkers of epithelial and mesenchymal cells, suggesting the mesenchymal-epithelial transition (MET) may be involved.

IJCEP Copyright © 2019.

Keywords: Epithelioid sarcoma; diagnosis; head; mesenchymal-epithelial transition; scalp

Conflict of interest statement

None.

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