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He S, Cheng Y, Zhang G, et al. Primary hepatic pregnancy: a case report with a history of cesarean section and oral contraceptives, with review of literature. Int J Clin Exp Pathol. 2019;12(12):4344-4348
He, S., Cheng, Y., Zhang, G., Qi, H., & Sun, Q. (2019). Primary hepatic pregnancy: a case report with a history of cesarean section and oral contraceptives, with review of literature. International journal of clinical and experimental pathology, 12(12), 4344-4348.
He, Shuqian, et al. "Primary hepatic pregnancy: a case report with a history of cesarean section and oral contraceptives, with review of literature." International journal of clinical and experimental pathology vol. 12,12 (2019): 4344-4348.
He S, Cheng Y, Zhang G, Qi H, Sun Q. Primary hepatic pregnancy: a case report with a history of cesarean section and oral contraceptives, with review of literature. Int J Clin Exp Pathol. 2019 Dec 01;12(12):4344-4348. eCollection 2019. PMID: 31933836; PMCID: PMC6949872.
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Int J Clin Exp Pathol. 2019 Dec 01;12(12):4344-4348. eCollection 2019.

Primary hepatic pregnancy: a case report with a history of cesarean section and oral contraceptives, with review of literature.

International journal of clinical and experimental pathology

Shuqian He, Yuxia Cheng, Guihui Zhang, Huangpeng Qi, Qing Sun

Affiliations

  1. Department of Pathology, Shandong Provincial Qianfoshan Hospital, First Hospital Affiliated with Shandong First Medical University Jinan, Shandong Province, China.

PMID: 31933836 PMCID: PMC6949872

Abstract

Primary hepatic pregnancy is an extremely rare event which is difficult to diagnose due to its unusual location; moreover the potential mortality rate is five to seven times higher than the rate found in other ectopic pregnancies. We report a case of primary hepatic pregnancy in a 23-year-old woman, who presented with a history of one cesarean section and had taken oral contraceptives within half a year prior to her presentation. Interestingly this patient has no history of amenorrhoea, and no clinical symptoms of chills, fever, nausea, vomiting and diarrhea. Imaging findings showed an abnormal mass on the lower part of the right lobe. The patient was misdiagnosed with a liver tumor prior to operation. Histopathologic examination found that chorionic villi with trophoblasts infiltrated the hepatic tissue. A few trophoblasts were detected in some hepatic veins. HCG immunostaining showed positive reactivity in the trophoblasts. We believe that some risk factors of primary hepatic pregnancy such as the history of cesarean section and oral contraceptive should be taken into serious consideration and raise the index of suspicion, especially in the women of reproductive age, with or without a history of amenorrhoea. Timely diagnosis should be made in order to avoid mortality from rupture of the gestational sac.

IJCEP Copyright © 2019.

Keywords: Primary hepatic pregnancy; cesarean section; etiology; oral contraceptive

Conflict of interest statement

None.

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