BJGP Open. 2020 May 01;4(1). doi: 10.3399/bjgpopen20X101010. Print 2020.
Cannabidiol prescription in clinical practice: an audit on the first 400 patients in New Zealand.
BJGP open
Graham Gulbransen, William Xu, Bruce Arroll
Affiliations
Affiliations
- Private Practitioner, Cannabis Care NZ, West Care Specialist Centre, Auckland, New Zealand [email protected].
- Medical Student, Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
- Professor and Head of Department, Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
PMID: 32019776
PMCID: PMC7330185 DOI: 10.3399/bjgpopen20X101010
Abstract
BACKGROUND: Cannabidiol (CBD) is the non-euphoriant component of cannabis. In 2017, the New Zealand Misuse of Drugs Regulations (1977) were amended, allowing doctors to prescribe CBD. Therapeutic benefit and tolerability of CBD remains unclear.
AIM: To review the changes in self-reported quality of life measurements, drug tolerability, and dose-dependent relationships in patients prescribed CBD oil for various conditions at a single institution.
DESIGN & SETTING: An audit including all patients (
RESULTS: Four hundred patients were assessed for CBD and 397 received a prescription. Follow-up was completed on 253 patients (63.3%). Patients reported a mean increase of 13.6 points (
CONCLUSION: There may be analgesic and anxiolytic benefits of CBD in patients with non-cancer chronic pain and mental health conditions such as anxiety. CBD is well tolerated, making it safe to trial for non-cancer chronic pain, mental health, neurological, and cancer symptoms.
Copyright © 2020, The Authors.
Keywords: analgesics; anti-anxiety agents; cannabidiol; cannabis; chronic pain; community care; depression; mental health; patient reported outcome measures; prescribing; therapy in mental health
References
- J Exp Med. 2012 Jun 4;209(6):1121-34 - PubMed
- Neuropsychopharmacology. 2011 May;36(6):1219-26 - PubMed
- Pharmacol Res. 2017 Jul;121:213-218 - PubMed
- Cannabis Cannabinoid Res. 2017 Jun 01;2(1):139-154 - PubMed
- Perm J. 2019;23:18-041 - PubMed
- CNS Drugs. 2018 Nov;32(11):1053-1067 - PubMed
- N Engl J Med. 2018 May 17;378(20):1888-1897 - PubMed
- J Clin Epidemiol. 2008 Apr;61(4):344-9 - PubMed
- Neurology. 2015 Feb 24;84(8):794-802 - PubMed
- Br J Pharmacol. 2011 Feb;162(3):584-96 - PubMed
- J Pharmacol Exp Ther. 2006 Feb;316(2):780-8 - PubMed
- Transl Psychiatry. 2012 Mar 20;2:e94 - PubMed
- Brain Res. 2012 Jan 11;1431:46-52 - PubMed
- Health Policy. 1996 Jul;37(1):53-72 - PubMed
- Braz J Psychiatry. 2008 Sep;30(3):271-80 - PubMed
- J Psychopharmacol. 1993 Jan;7(1 Suppl):82-8 - PubMed
- Pain. 2019 Jan;160(1):136-150 - PubMed
- N Engl J Med. 2017 May 25;376(21):2011-2020 - PubMed
- Cochrane Database Syst Rev. 2013 Apr 30;(4):CD005175 - PubMed
- J Psychopharmacol. 2011 Jan;25(1):121-30 - PubMed
- Can Fam Physician. 2018 Feb;64(2):111-120 - PubMed
- Front Pharmacol. 2017 May 11;8:259 - PubMed
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