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Front Oncol. 2020 Jan 14;9:1498. doi: 10.3389/fonc.2019.01498. eCollection 2019.

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Frontiers in oncology

Giovanna Navarra, Cristina Pagano, Roberto Pacelli, Elvira Crescenzi, Elena Longobardi, Patrizia Gazzerro, Donatella Fiore, Olga Pastorino, Francesca Pentimalli, Chiara Laezza, Maurizio Bifulco

Affiliations

  1. Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II," Naples, Italy.
  2. Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy.
  3. Institute of Endocrinology and Experimental Oncology, Institute of Endocrinology and Experimental Oncology (IEOS), National Research Council (CNR), Naples, Italy.
  4. Section of Pharmacology, Department of Neuroscience University of Naples Federico II, Naples, Italy.
  5. Department of Pharmacy, University of Salerno, Naples, Italy.
  6. Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Naples, Italy.

PMID: 31993371 PMCID: PMC6971108 DOI: 10.3389/fonc.2019.01498

Abstract

Glioblastoma is among the most common malignant brain tumors and has a dismal prognosis due to the poor response to therapeutic regimens such as ionizing radiation and DNA-alkylating agents. In our study, we investigated the radiosensitizing activity of the N

Copyright © 2020 Navarra, Pagano, Pacelli, Crescenzi, Longobardi, Gazzerro, Fiore, Pastorino, Pentimalli, Laezza and Bifulco.

Keywords: RAD51; STAT5a/b; apoptosis; glioblastoma cells; iPA

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