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De Lazzari F, Sandrelli F, Whitworth AJ, et al. Antioxidant Therapy in Parkinson's Disease: Insights from . Antioxidants (Basel). 2020;9(1)doi: 10.3390/antiox9010052.
De Lazzari, F., Sandrelli, F., Whitworth, A. J., & Bisaglia, M. (2020). Antioxidant Therapy in Parkinson's Disease: Insights from . Antioxidants (Basel, Switzerland), 9(1), . https://doi.org/10.3390/antiox9010052
De Lazzari, Federica, et al. "Antioxidant Therapy in Parkinson's Disease: Insights from ." Antioxidants (Basel, Switzerland) vol. 9,1 (2020). doi: https://doi.org/10.3390/antiox9010052
De Lazzari F, Sandrelli F, Whitworth AJ, Bisaglia M. Antioxidant Therapy in Parkinson's Disease: Insights from . Antioxidants (Basel). 2020 Jan 07;9(1). doi: 10.3390/antiox9010052. PMID: 31936094; PMCID: PMC7023233.
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Antioxidants (Basel). 2020 Jan 07;9(1). doi: 10.3390/antiox9010052.

Antioxidant Therapy in Parkinson's Disease: Insights from .

Antioxidants (Basel, Switzerland)

Federica De Lazzari, Federica Sandrelli, Alexander J Whitworth, Marco Bisaglia

Affiliations

  1. Department of Biology, University of Padova, 35131 Padova, Italy.
  2. Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.

PMID: 31936094 PMCID: PMC7023233 DOI: 10.3390/antiox9010052

Abstract

Reactive oxygen species (ROS) play an important role as endogenous mediators in several cellular signalling pathways. However, at high concentrations they can also exert deleterious effects by reacting with many macromolecules including DNA, proteins and lipids. The precise balance between ROS production and their removal via numerous enzymatic and nonenzymatic molecules is of fundamental importance for cell survival. Accordingly, many neurodegenerative disorders, including Parkinson's disease (PD), are associated with excessive levels of ROS, which induce oxidative damage. With the aim of coping with the progression of PD, antioxidant compounds are currently receiving increasing attention as potential co-adjuvant molecules in the treatment of these diseases, and many studies have been performed to evaluate the purported protective effects of several antioxidant molecules. In the present review, we present and discuss the relevance of the use of

Keywords: Drosophila melanogaster; Parkinson’s disease; SOD-mimetics; antioxidants; oxidative damage

Conflict of interest statement

The authors declare no conflict of interest.

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