Am J Primatol. 1981;1(4):413-419. doi: 10.1002/ajp.1350010406.

Hematological and serum biochemical values in free-ranging Macaca fascicularis of mauritius: Possible diabetes mellitus and correlation with nutrition.

American journal of primatology

Ian Tattersall, Andrea Dunaif, Robert W Sussman, Robert Jamieson

PMID: 31995913 DOI: 10.1002/ajp.1350010406

Abstract

Obtained values are presented from a study of blood biochemistry and hematology of free-ranging crab-eating macaques (Macaca fascicularis) in Mauritius. Normal values are generally comparable to those previously obtained from laboratory populations of this species. Abnormal values included elevated serum glucose and triglycerides in certain individuals that suggested glucose intolerance and diabetes mellitus. A high-carbohydrate diet consisting of large proportions of sugar cane and molasses may have unmasked a genetic predisposition to diabetes in these animals.

Copyright © 1981 Wiley‐Liss, Inc., A Wiley Company.

Keywords: Macaca fascicularis; blood values; diabetes mellitus; free‐ranging crab‐eating macaques; glucose intolerance

References

1. Allen, J. R.; Carstens, L. A. Hematologic alterations observed in newly acquired monkeys during a period of their isolation. Laboratory Animal Care 15: 103–110, 1965. - PubMed
2. Altshuler, H. L.; Stowell, R. E.; Lowe, R. T. Normal serum biochemical values of Macaca aretoides, Macaca fascicularis, and Macaca radiata. Laboratory Animal Science 21: 916–926, 1971. - PubMed
3. Blakley, G. A.; Morrow, A. C.; Morton, W. R. Intraspecies variation in serum cholesterol levels in imported Macaca nemestrina. Laboratory Animal Science 23: 119–123, 1973. - PubMed
4. Christen, P.; Peacock, W. C.; Christen, A. E.; Wacker, W. E. C. Urate oxidase in primates. Folia Primatologia 13: 35–39, 1970. - PubMed
5. Crosby, W. H.; Munn, J. I.; Furth, F. W. Standardizing a method for clinical hemoglobinometry. United States Armed Forces Medical Journal 5: 693–703, 1954. - PubMed
6. DiGiacomo, R. F.; Myers, R. E.; Baez, L. R. Diabetes mellitus in a rhesus monkey (Macaca mulatta): A case report and literature review. Laboratory Animal Science 21: 572–574, 1971. - PubMed
7. Fiske, C. H.; Subbarow, Y. The colorimetric determination of phosphorus. Journal of Biological Chemistry 66: 375–400, 1925. - PubMed
8. Hamilton, C. L.; Ciaccia, P. The course of development of glucose intolerance in the monkey (Macaca mulatta). Journal of Medical Primatology 7: 165–173, 1978. - PubMed
9. Henry, R. J. Clinical Chemistry: Principles and Techniques. New York, Harper and Row, 1964. - PubMed
10. Holvey, D. N. The Merck Manual of Diagnosis and Therapy, 12th ed. Rahway, Merck, Sharp and Dohme, 1972. - PubMed
11. Honjo, S.; Kondo, Y.; Cho, F. Oral glucose tolerance test in the cynomolgus monkey (Macaca fascicularis). Laboratory Animal Science 26: 771–776, 1976. - PubMed
12. Howard, C. F., Jr. Spontaneous diabetes in Macaca nigra. Diabetes 21: 1077–1090, 1972. - PubMed
13. Howard, C. F., Jr. Correlations of serum triglyceride and prebetalipoprotein levels to the severity of spontaneous diabetes in Macaca nigra. Journal of Clinical Endocrinology and Metabolism 38: 856–860, 1974a. - PubMed
14. Howard, C. F., Jr. Diabetes in Macaca nigra: Metabolic and histologic changes. Diabetologia 10: 671–677, 1974b. - PubMed
15. Huser, H. J. Atlas of Comparative Hematology. New York, Academic Press, 1970. - PubMed
16. Jones, S. M. Spontaneous diabetes in monkeys. Laboratory Animals 8: 161–166, 1974. - PubMed
17. Kawanishi, Y.; Cho, F.; Honjo, S. Normal values of the serum protein fractions in cynomolgus monkeys used as experimental animals. Japan Journal of Medical Science (Biology) 26: 249–260, 1973. - PubMed
18. Kirk, J. H.; Casey, H. W.; Harwell, J. W. Diabetes mellitus in two rhesus monkeys. Laboratory Animal Science 21: 245–248, 1972. - PubMed
19. Loomis, M. R.; Henrickson, R. V.; Anderson, J. H. Effects of ketamine hydrochloride on the hemogram of rhesus monkeys (Macaca mulatta). Laboratory Animal Science 30: 851–853, 1980. - PubMed
20. McInroy, R. A. A micro‐hematocrit for determining the packed cell volume and hemoglobin concentration on capillary blood. Journal of Clinical Pathology 7: 32–36, 1954. - PubMed
21. Miale, J. B. Laboratory Medicine Hematology, 2nd ed. St. Louis, Mosby, 1962. - PubMed
22. Oser, F.; Lang, R. E.; Vogin, E. E. Blood values in stumptailed macaques (Macaca arctoides) under laboratory conditions. Laboratory Animal Care 20: 462–466, 1970. - PubMed
23. Saifer, A. Photometric determination of total and free cholesterol and the cholesterol‐ester ratio of serum by a modified Lieberman‐Buchard method. American Journal of Clinical Pathology 21: 24–32, 1951. - PubMed
24. Srinivasan, S. R.; Clevidence, B. A.; Parganokar, P. S.; Radhakrishnamurthy, B.; Berenson, G. S. Varied affects of dietary sucrose and cholesterol on serum lipids, lipoproteins and apolipoproteins in rhesus monkeys. Atherosclerosis 33: 301–314, 1979. - PubMed
25. Steyn, D. G. The effects of captivity stress on the blood chemical values of the chacma baboon (Papio ursinus). Laboratory Animals 9: 111–120, 1975. - PubMed
26. Sussman, R. W.; Tattersall, I. Behavior and ecology of Macaca fascicularis: A preliminary study. Primates 22: 192–205, 1981. - PubMed
27. Tisher, C. G.; Schrier, R. W.; McNeil, J. S. Nature of urine concentrating mechanism in the macaque monkey. American Journal of Physiology 223: 1128–1137, 1972. - PubMed
28. Vogin, E. E.; Oser, F. Comparative blood values in several species of nonhuman primates. Laboratory Animal Science 21: 937–941, 1971. - PubMed
29. White, J. A. M.; Bolstridge, M. C.; Downing, H. J.; Wessels, B. C.; Klomfass, H. J. Effects of stress on the results of glucose tolerance tests performed on vervet monkeys (Cercopithecus pygerythrus F. Cuvier). Journal of the South African Veterinary Association 44: 379–381, 1973. - PubMed
30. Wintrobe, M. M. Clinical Hematology. Philadelphia, Lea and Febiger, 1961. - PubMed

Publication Types

• Journal Article