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Front Pharmacol. 2020 Jan 23;10:1547. doi: 10.3389/fphar.2019.01547. eCollection 2019.

The Dorsomedial Hypothalamus Is Involved in the Mediation of Autonomic and Neuroendocrine Responses to Restraint Stress.

Frontiers in pharmacology

Taíz F S Brasil, Silvana Lopes-Azevedo, Ivaldo J A Belém-Filho, Eduardo A T Fortaleza, José Antunes-Rodrigues, Fernando M A Corrêa

Affiliations

  1. Department of Pharmacology of the School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  2. Department of Physiology of the School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

PMID: 32038236 PMCID: PMC6989482 DOI: 10.3389/fphar.2019.01547

Abstract

We hypothesized that dorsomedial hypothalamus (DMH) modulates autonomic and neuroendocrine responses in rats at rest and when subjected to restraint stress (RS). Male Wistar rats were used, and guide cannulas were bilaterally implanted in the DMH for microinjection of vehicle or the nonspecific synaptic blocker CoCl

Copyright © 2020 Brasil, Lopes-Azevedo, Belém-Filho, Fortaleza, Antunes-Rodrigues and Corrêa.

Keywords: CoCl2; cardiovascular response to stress; dorsomedial hypothalamus; neuroendocrine response; restraint stress

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