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Corciulo C, Cronstein BN. Signaling of the Purinergic System in the Joint. Front Pharmacol. 2020;10:1591doi: 10.3389/fphar.2019.01591.
Corciulo, C., & Cronstein, B. N. (2019). Signaling of the Purinergic System in the Joint. Frontiers in pharmacology, 101591. https://doi.org/10.3389/fphar.2019.01591
Corciulo, Carmen, and Cronstein, Bruce N. "Signaling of the Purinergic System in the Joint." Frontiers in pharmacology vol. 10 (2019): 1591. doi: https://doi.org/10.3389/fphar.2019.01591
Corciulo C, Cronstein BN. Signaling of the Purinergic System in the Joint. Front Pharmacol. 2020 Jan 24;10:1591. doi: 10.3389/fphar.2019.01591. eCollection 2019. PMID: 32038258; PMCID: PMC6993121.
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Front Pharmacol. 2020 Jan 24;10:1591. doi: 10.3389/fphar.2019.01591. eCollection 2019.

Signaling of the Purinergic System in the Joint.

Frontiers in pharmacology

Carmen Corciulo, Bruce N Cronstein

Affiliations

  1. Division of Translational Medicine, Department of Medicine, NYU School of Medicine, New York, NY, United States.
  2. Krefting Research Centre-Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  3. Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY, United States.

PMID: 32038258 PMCID: PMC6993121 DOI: 10.3389/fphar.2019.01591

Abstract

The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body. All the joints have a similar composition including cartilage for reducing the friction of the movement and protecting the underlying bone, a synovial membrane that produces synovial fluid to lubricate the joint, ligaments to limit joint movement, and tendons for the interaction with muscles. Direct or indirect damage of one or more of the tissues forming the joint is the foundation of different pathological conditions. Many molecular mechanisms are involved in maintaining the joint homeostasis as well as in triggering disease development. The molecular pathway activated by the purinergic system is one of them.The purinergic signaling defines a group of receptors and intermembrane channels activated by adenosine, adenosine diphosphate, adenosine 5'-triphosphate, uridine triphosphate, and uridine diphosphate. It has been largely described as a modulator of many physiological and pathological conditions including rheumatic diseases. Here we will give an overview of the purinergic system in the joint describing its expression and function in the synovium, cartilage, ligament, tendon, and bone with a therapeutic perspective.

Copyright © 2020 Corciulo and Cronstein.

Keywords: adenosine; adenosine diphosphate; adenosine triphosphate; bone; cartilage; purine; synovium; tendon

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