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Elshaarawy O, Mueller J, Guha IN, et al. Spleen stiffness to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications. JHEP Rep. 2019;1(2):99-106doi: 10.1016/j.jhepr.2019.05.003.
Elshaarawy, O., Mueller, J., Guha, I. N., Chalmers, J., Harris, R., Krag, A., Madsen, B. S., Stefanescu, H., Farcau, O., Ardelean, A., Procopet, B., Thiele, M., & Mueller, S. (2019). Spleen stiffness to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications. JHEP reports : innovation in hepatology, 1(2), 99-106. https://doi.org/10.1016/j.jhepr.2019.05.003
Elshaarawy, Omar, et al. "Spleen stiffness to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications." JHEP reports : innovation in hepatology vol. 1,2 (2019): 99-106. doi: https://doi.org/10.1016/j.jhepr.2019.05.003
Elshaarawy O, Mueller J, Guha IN, Chalmers J, Harris R, Krag A, Madsen BS, Stefanescu H, Farcau O, Ardelean A, Procopet B, Thiele M, Mueller S. Spleen stiffness to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications. JHEP Rep. 2019 Jun 21;1(2):99-106. doi: 10.1016/j.jhepr.2019.05.003. eCollection 2019 Aug. PMID: 32039357; PMCID: PMC7001583.
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JHEP Rep. 2019 Jun 21;1(2):99-106. doi: 10.1016/j.jhepr.2019.05.003. eCollection 2019 Aug.

Spleen stiffness to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications.

JHEP reports : innovation in hepatology

Omar Elshaarawy, Johannes Mueller, Indra Neil Guha, Jane Chalmers, Rebecca Harris, Aleksander Krag, Bjørn Stæhr Madsen, Horia Stefanescu, Oana Farcau, Andreea Ardelean, Bogdan Procopet, Maja Thiele, Sebastian Mueller

Affiliations

  1. Department of Medicine and Center for Alcohol Research, Salem Medical Center, University of Heidelberg, Zeppelinstraße 11-33, 69121 Heidelberg, Germany.
  2. NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.
  3. Department of Gastroenterology and Hepatology and Odense Patient data Exploratory Network, OPEN, Odense University Hospital, Odense, Denmark.
  4. Department of Hepatology and Liver Research Club, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.

PMID: 32039357 PMCID: PMC7001583 DOI: 10.1016/j.jhepr.2019.05.003

Abstract

BACKGROUND & AIMS: Both liver stiffness (LS) and spleen stiffness (SS) are widely used to non-invasively assess liver fibrosis and portal hypertension, respectively. We aimed to identify the impact of disease etiology, namely the localization of inflammation (portal

METHODS: In this multicenter study, LS and SS were prospectively assessed in 411 patients with alcohol-related liver disease (ALD) or hepatitis C virus (HCV) using FibroScan® (Echosens, Paris); changes in these parameters were also studied in response to treatment (alcohol withdrawal, HCV therapy). LS and spleen length (SL) were further analyzed in a retrospective cohort of 449 patients with long-term data on decompensation/death.

RESULTS: Both, SS and SL were significantly higher in HCV compared to ALD (42.0

CONCLUSION: Both SS/LS and SL/LS ratios are significantly higher in patients with portal HCV compared to lobular ALD. Thus, combined LS and SS or SL measurements provide additional information about disease etiology and disease-specific complications.

LAY SUMMARY: Herein, we show that patients with hepatitis C virus infection (HCV) have higher spleen stiffness and portal pressure than patients with alcohol-related liver disease (ALD), within the same fibrosis stage and matched to liver stiffness. Thus, the spleen stiffness to liver stiffness ratio is significantly higher in patients with HCV compared to ALD. Additionally, patients with HCV more commonly progress to portal hypertension-related complications (

Crown Copyright © 2019 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).

Keywords: Cirrhosis; DAAs; alcohol detoxification; liver decompensation; portal hypertension

References

  1. J Hepatol. 1996;24(2 Suppl):35-42 - PubMed
  2. Hepatology. 1992 Apr;15(4):572-7 - PubMed
  3. Therap Adv Gastroenterol. 2017 Aug;10(8):619-629 - PubMed
  4. Gastroenterol Hepatol. 2012 Aug-Sep;35(7):488-95 - PubMed
  5. J Hepatol. 2010 Feb;52(2):206-10 - PubMed
  6. J Virol. 2012 Jun;86(11):6315-22 - PubMed
  7. J Hepatol. 2008 May;48(5):835-47 - PubMed
  8. World J Gastroenterol. 2014 Oct 28;20(40):14626-41 - PubMed
  9. World J Gastroenterol. 2016 Dec 28;22(48):10482-10501 - PubMed
  10. World J Gastroenterol. 2016 Jan 28;22(4):1357-66 - PubMed
  11. J Hepatol. 2014 Jun;60(6):1158-64 - PubMed
  12. Gastroenterology. 2005 Feb;128(2):343-50 - PubMed
  13. Hepatology. 2016 Dec;64(6):2173-2184 - PubMed
  14. Am J Gastroenterol. 2006 Jul;101(7):1500-8 - PubMed
  15. Gastroenterology. 1982 Oct;83(4):777-85 - PubMed
  16. World J Gastroenterol. 2010 Feb 28;16(8):966-72 - PubMed
  17. Hepatology. 1996 Aug;24(2):289-93 - PubMed
  18. Hepatology. 2008 Feb;47(2):380-4 - PubMed
  19. Alcohol Clin Exp Res. 2011 Mar;35(3):566-70 - PubMed
  20. Hepatology. 2017 Jul;66(1):96-107 - PubMed
  21. Liver Int. 2015 Dec;35(12):2514-21 - PubMed
  22. Am J Gastroenterol. 2013 Jul;108(7):1101-7 - PubMed
  23. Gut. 2016 Feb;65(2):354-5 - PubMed
  24. J Hepatol. 1991 Nov;13(3):372-4 - PubMed
  25. Hepatology. 2013 Mar;57(3):1278-80 - PubMed
  26. Hepatology. 2013 Mar;57(3):1182-91 - PubMed
  27. Clin Liver Dis (Hoboken). 2013 Apr 24;2(2):64-67 - PubMed
  28. J Biol Chem. 1993 Dec 5;268(34):25803-10 - PubMed
  29. J Hepatol. 2006 Jan;44(1):217-31 - PubMed
  30. Medicine (Baltimore). 2015 Jun;94(24):e1031 - PubMed
  31. Ultrasound Med Biol. 2018 Aug;44(8):1616-1626 - PubMed
  32. Lancet Gastroenterol Hepatol. 2018 Sep;3(9):614-625 - PubMed
  33. J Hepatol. 1991 Jan;12(1):83-6 - PubMed
  34. Gastroenterology. 2016 May;150(5):1160-1170.e3 - PubMed
  35. J Gastroenterol Hepatol. 2011 Jan;26(1):164-70 - PubMed
  36. Gastroenterology. 2012 Sep;143(3):646-654 - PubMed
  37. Gastroenterology. 2016 Jan;150(1):123-33 - PubMed

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